Tetracaine raw khoom hmoov hmoov kho hmoov kho rau kev ntxov Ejaculation CAS: 94-24-6

Dab tsi yog tetracaine cov khoom siv raw hmoov zoo li cas?

Tetracaine HCL (Tshuaj lom neeg lub npe: 2 {} (Dethylamino) benzoate hydrocoate) yog ester-chav kawm-chav kawm antesthetic. Nyob rau hauv nws cov khoom lag luam raw, nws yog ib qho zoo, dawb, crystalline hmoov uas yog soluble nyob hauv dej thiab cawv. Qhov solubility no yog qhov tseem ceeb rau nws cov qauv ua rau hauv ntau lub tshuab tshuaj siv khoom. Raws li ib qho API, nws txoj kev coj dawb huv yog nruj me ntsis kev tswj hwm los ntawm cov kws kho mob (xws li USP / NF lossis PHOT.), Kom muaj kev ua tau zoo los yog kev nyab xeeb. Nws yog synthesis-derived compound, tsis muab rho tawm los ntawm cov chaw ua kom zoo rau kev ua kom tiav ntawm nws cov khoom siv tshuaj loog anesthetic.

Tetracaine's profile yog txhais los ntawm ob peb tug sib txawv ntawm lwm cov tshuaj loog hauv cheeb tsam zoo li Lidocaine lossis Bupivacaine:

1.hov potency:Tetracaine yog kwv yees li 8-10 lub sij hawm muaj zog tshaj procaine thiab muaj zog ntau dua liidocaine. Qhov kev ua kom siab no cuam tshuam txhais tau tias kev ua kom zoo nkauj tuaj yeem ua tiav nrog cov tshuaj qis qis dua ntawm cov tshuaj ntawm lub vev xaib.

2.Nlong Lub sijhawm ntev ntawm kev txiav txim:Nws muab ib qho ntawm cov kav ntev tshaj plaws ntawm cov kev xav ntawm cov tshuaj loog hauv cheeb tsam. Nws cov kev cuam tshuam tuaj yeem mob siab txog li 3 {{{{- 4 teev, lossis tseem ntev dua thaum siv tau qhov muaj peev xwm ntau yam uas ua rau ib puag ncig kev nqus thiab kev tshem tawm los ntawm neuronal ib puag ncig.

3.high lipid solubility:Cov cuab yeej no tso cai rau kev nkag tau los ntawm Lipid - ricin riciion rau ntawm cov dej qab zib ntawm cov hlab ntaws ntawm cov hlab ntaws.

4.ester -} lit cov metabolism:Raws li qhov Ester -}}}}}}}}}}}}}}}} Cov ntshav sai sai rau cov ntshav los ntawm ntshav pseudocholinesterase. Qhov no yog qhov kev nyab xeeb tseem ceeb, raws li feem ntau txwv kev ua haujlwm toxicity. Txawm li cas los xij, cov tib neeg uas muaj caj ces tsis muaj peev xwm ntawm cov enzyme no (atypical pseudocholinesterase) yog nyob rau ntawm qhov kev pheej hmoo ntawm kev lom zem.

Mechanism ntawm Kev Ua:Tetracaine nthuav tawm nws cov nyhuv los ntawm thim rov qab rau kev nthuav dav tshwj xeeb {{mate} Cov tso sodium nyob rau sab hauv ntawm neuronal membrane. Qhov no khi inhibits qhov kev hloov pauv kev hloov uas tsim nyog rau kev ua kom tau zoo. Los ntawm kev tiv thaiv sodium ion Inclium, tetracaine Halters Qhov pib thiab kev hais tawm ntawm qhov muaj peev xwm. Cov hlab ntaws ua kom ruaj khov thiab tsis tuaj yeem cuam tshuam didolarize, ua rau ib qho kev ua tiav ntawm cov kev xav (thiab tsawg dua, lub cev muaj zog) hlab tsheb kis.

Kev siv cov khoom siv tetracaine yog yuav luag txhua yam hauv kev tsim kho mob kev tshaj lij vim nws qhov kev pheej hmoo siab thiab cuam tshuam nrog kev pheej hmoo. Nws thawj cov ntawv thov yog:

1.Spinal tshuaj loog (subarachnoid block):Nov yog daim ntawv qhia tseem ceeb tshaj plaws rau tetracaine. Tsim los ua cov tshuaj hnyav (feem ntau hauv dextrose), nws tau txhaj rau kev phais cov kua tshuaj kom ua tiav kev phais mob hauv qab no, xws li mob plab, thiab phais mob qis dua. Nws lub sijhawm ntev ua rau nws zoo tshaj plaws rau lub caij nyoog ua haujlwm.

2.Txem tshuaj loog:Tetracaine yog qhov tseem ceeb ntawm cov ntsiab lus, suav nrog cream, gels, thiab ophthalmic daws teeb meem. Nws lub potency loj tso cai rau kev ua tau zoo ntawm kev ua kom zoo. Tshwj xeeb, nws yog siv nyob rau hauv:

OpHThalmology:Txog cov txheej txheem xws li tonometry, cataract tshem tawm, thiab corneal tawm ntawm lub cev txawv teb chaws.

Otolaryngology:Txhawm rau kom ua kom lub cev nqaij daim tawv ntawm lub qhov ntswg, pharynx, thiab liarynx ua ntej kev kuaj mob endoscopic.

○ Dermatology:Nyob rau hauv compounded creamed rau cov dermathological cov txheej txheem.

3.Txoj kev sib zog thiab cov hlab ntsha at austes:Thaum tsis tshua muaj vim muaj kev muaj kev nyab xeeb uas muaj kev nyab xeeb zoo li Lidocaine thiab Bupivacaine, tetracaine tuaj yeem siv rau cov pob zeb uas muaj pob zeb. Nws siv yog feem ntau hauv kev sib xyaw nrog tus luv dua- ua yeeb yam tus neeg sawv cev rau nrawm dua thaum lub sijhawm ntev.

Tus thawjkev pabntawm tetracaine yog nws lub peev xwm muabmuaj peev xwm thiab ntev -} kav esteshesialos ntawm ib tus thawj coj. Qhov no yog qhov tsis txaus ntseeg hauv kev ua phem rau txha caj qaum rau kev phais ntev, txo qhov xav tau ntawm kev noj tshuaj dua lossis hloov dua siab tshiab rau cov tshuaj loog dav dav. Nws qhov kev ua tau zoo ua tus neeg sawv cev pleev ib yam muab cov neeg mob siab rau lwm yam kev mob siab.

Kev tuav ntawm cov hmoov tetracaine xav tau kev ceev heev. Dosages yog moticulously suav hauv milligrams thiab yog qhov tseem nyob ntawm txoj kev tswj hwm, thiab tus neeg muaj qee yam dej num tshwj xeeb).

● Cov tshuaj loog mob caj pas:Cov koob tshuaj raug ntawm5 mg rau 20 mgCov. Cov koob tshuaj tshwj xeeb yog ua tib zoo teev nyob rau ntawm qhov xav tau qhov siab thiab ntev ntawm qhov thaiv. Piv txwv li, lub sijhawm 10-15 MG yuav muab cov tshuaj loog rau 1.5-2.5 teev rau cov txheej txheem perineal.

Applicate daim ntawv thov:Kev siv ntau rau ophthalmic siv yog feem ntau0.5%, thaum daws teeb meem rau cov tawv nqaij nyias muaj peev xwm tau los ntawm1% rau 2%Cov. Tag nrho cov koob tshuaj yuav tsum raug saib xyuas kom tsis txhob muaj kev nqus cov kab.

Kev voj voog (pib thiab sijhawm):

● Pib ua haujlwm:Qhov pib rau tus txha caj qaum yog qhov nrawm nrawm, hauv ob peb feeb. Daim ntawv thov cov ntsiab lus ntawm cov kua mis nyhav yuav siv sijhawm 1-2 feeb rau tag nrho cov nyhuv. Nws yog qhov tseem ceeb yog qeeb qeeb tshaj li ntawm Lidocaine.

Ntev ntev li cas:Qhov no yog tegracaine lub lawb npe. Cov pob txha nqaj qaum yuav kawg2-3 teev, nrog kev rov qab tag nrho noj ob peb teev ntau dua. Kev tshuaj loog nti cov tshuaj loog ntev ntev rau kev siv sijhawm txaus kom ua tiav cov txheej txheem feem ntau.

Ib nrab - lub neej:
Lub plasma ib nrab - lub neej ntawm tetracaine yog luv heev, kwv yees yuavTsawg dua 1 feebnyob rau hauv cov tib neeg uas muaj pseudocholinester enzyme. Qhov no vim tias nws yog hydrolyzed yog li sai sai hauv cov hlab ntshav rau para-}}}) thiab lwm cov metabolites. Txawm li cas los xij, tusUa haujlwm ib nrab - lub neej(Lub sijhawm muaj txiaj ntsig ntawm lub suab paj nruag) yog ntev vim nws cov ntaub so ntswg siab khi thiab qeeb tawm los ntawm cov neuronal ib puag ncig. Qhov no disconnect ntawm ntshav ib nrab ib nrab - lub neej thiab chaw kuaj mob yog tus yam ntxwv tseem ceeb.

Thaum lub sij hawm "percutaneity toxicity concentration" (PTC) tsis yog tus qauv, thoob ntiaj teb tau txhais nyob rau hauv cov ntsiab lus ntawm tetracaine qhov tseem ceebLub kaw lus kev pheej hmoo.

Tetracaine muaj aHeev nqaim kev ntsuas ntsuasCov. Nws lub siab loj txhais tau tias cov npoo ntawm ib koob tshuaj thiab koob tshuaj lom yog me me. Systemic kev lom zem feem ntau cuam tshuam covCentral Qervous System (Cns)Thiab tusCov hlab plawv (CVS).

● CNS TOXICITY:Qhia ua ntej thaum thawj zaug kev zam txim (tshee hnyo, kiv taub, tshee, tshee, qaug dab peg) ua raws los ntawm kev nyuaj siab (ua pa rau kev ua pa, coma).

RVS TOXICITY:Cov txiaj ntsig hauv Myocardial kev nyuaj siab, kev xav tsis txaus siab, Bradycardia, thiab muaj peev xwm them nqi. Kev vau zuj zus tuaj yeem tshwm sim tsis muaj cov tsos mob cns ua ntej, tshwj xeeb yog muaj cov neeg sawv cev muaj zog xws li Tetracaine.

Yog li ntawd, "kev thaj yeeb nyab xeeb" rau txhua qhov kev tsim, tshwj xeeb yog cov txuj ci, yog qhov tseem ceeb. Rau cov kev daws cov ntsiab lus ntawm cov ntsiab lus, qhov ntau, 1-2%), thiab daim tawv nqaij tawg heev kom tiv thaiv kom tsis txhob muaj kev tiv thaiv sai. Tag nrho cov koob tshuaj rau kev siv cov tshuaj pleev yuav tsum muaj tsawg.

Qhov kev cuam tshuam no yog vim li cas tetracaine cov khoom siv raw yogtsis yog rau cov neeg siv khoom lossis kev siv amateurCov. It is a substance that demands respect, handled only by qualified professionals (anesthesiologists, pharmacists, surgeons) who understand its pharmacokinetics, can calculate safe dosages, and are equipped to manage life-threatening toxic reactions immediately. Kev kho kom tau txais ntawm Lipid emulsion kev kho raws li cov tshuaj tiv thaiv kev ua kom loog hauv cheeb tsam hauv ib qho kev nyab xeeb uas yuav tsum tau siv qhov twg tetracaine siv.

Kev Lag Luam Npe	Tetracaine, Amethocaine, Pontocaine, Ametop, Dicaine
Cas	94-24-6
Tus hniav loj	264.37
Mf	C15H24N2O2
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	Dawb crystalline hmoov

 

 

Kev xav tau, thov hu rau peb

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Tetracaine hydrochloride raw khoom hmoov tsis yog thawj {kab} kab ua tshuaj loog rau txhua cov txheej txheem, tab sis cov cuab yeej tshwj xeeb hauv kev ua haujlwm. Nws tus kheej yog txhais los ntawm cov tsis muaj kev sib txuam potency thiab thiav, ua rau nws tsis tseem ceeb rau txha caj qaum thiab muaj zog tshaj tawm. Nws tus nqi yog txuas nrog cov formidable profile, tsim nyog nruj nruj tuav tuav, tshuaj lom zem, thiab ceev faj tus neeg mob saib xyuas. Nws cov kev tshem tawm sai sai yog ua {4 4}} hauv kev nyab xeeb mechanism uas tsuas yog siv nyob rau hauv cov ciaj ciam ntawm kev siv tshuaj kho kom zoo. Thaum kawg, tetracaine ua tau zoo tshaj plaws lub ntsiab cai ntawm cov chaw muag tshuaj: cov cuab yeej siv tau zoo yog cov uas xav tau kev hwm thiab kev tshaj lij.

Cim npe nrov: Tetracaine Cov Khoom Siv Raw Hmoov Txog Kev Kho Mob Ejaculation Hmoov Zoo Li Cas: 94-24-6ersters, Chaw Tsim Tshuaj, Hoobkas