Stromusc nolvax (tamoxifen) 10mg rau lub cev kev ua haujlwm ntawm lub cev: 10540-29-1

Dab tsi yog nolvadex (tamoxifen)?

Tus Kheej Tus Kheej:Tamoxifen yog aEstrogen Estrogen tus kws muab khoom siv (txuj ci).} tsis zoo li aromatase inhibitors (AIS) uas thaiv cov khoom siv tshuaj ntsuab (ers) hauv cov ntaub so ntswg tshwj xeeb, ua yeeb yam raws li ib qhotxawj txiv neej(MimScking estrogen) lossis ibthaiv kev(Thaiv cov tshuaj ntsuam), nyob ntawm seb daim ntaub so ntswg .

● Mechanism ntawm kev nqis tes ua:Tamoxifen cov haujlwm feem ntau yog ib qhoEstrogen receptor tiv thaiv nyob rau hauv cov ntaub so ntswg. Qhov no tiv thaiv cov tshuaj estrogen lossis hluavtaws rov qab los ntawm steromatized steroids (zoo ib yam li proliferative cuam tshuam rau hauv lub mis. crucous, nws ua raws li aIb nrab agonist hauv lwm cov ntaub so ntswg, xws li pob txha (pab tswj kev ceev) thiab qhov endometrium (uas nqa cov kev pheej hmoo (saib hauv qab no) .

Keeb Kwm:Tsim thiab tau txais kev pom zoo thoob ntiaj teb thiab kev tiv thaiv estrogen receptor-zoo (ER +) tus mob cancer mis hauv ob qho tib si .

● Cov nqaij xaiv:Qhov no yog nws txhais tau hais feature {{}}}}}}}} agonional nyob rau hauv cov pob qij txha, "Gyno")

● Qhov ncauj cov khoom siv:Zoo-nqus thaum noj qhov ncauj lus, ua rau nws yooj yim.

● Metabolism:Feem ntau metabolized nyob rau hauv daim siab los ntawm Cytochrome P450 System (feem ntau yog cov meyoxifen zoo li tam endabifen hauv Cyps {{8 8}}

● Kev sib tham tau zoo:Tamoxifen tuaj yeem txhawb nqa progesterone receptors . Nyob rau hauv cov ntsiab lus ntawm lub cev, zoo li nandrolone lossis trenbolone lossis trenbolone) feem ntau siv, qhov notej zaumtheoretically pab txhawb rau progestogenic gyno kev loj hlob, Txawm hais tias nws lub luag haujlwm tseem ceeb nyob enserrogen-tsav gyno .

● Hepatic qhov teebmeem:Nws tuaj yeem ua rau muaj kev tshaib plab thiab cov neeg thauj khoom nce hauv daim siab hepatotoxicity ({

Cov ntsiav tshuaj 10mg tso cai rau kev ua kom meej meejancillary thiab kho:

● Gynecomastia tiv thaiv thiab thim rov qab:Nov yog tusthawj thiab feem ntau siv tau siv{{0. thaum lub sijhawm caij tsheb steromatizable (tamoxify nyob rau hauv kev txhim kho cov nqaij mos. qhov muag heev,ntawm thawj cov cim ntawm Gyno(khaus, puffiness, TAMOXIFEN 10MG feem ntau yog qhov kev cuam tshuam ua ntej thiab muaj peev xwm rov qab los ntawm cov ntaub so ntswg thaum ntxovua kev paujtshaj li itis ib zaug Gyno tau pib .

● Kev voj voog rau kev voj voog (PCT):Qhov no yog qhov kev thov thib ob . Axis Testosterone Ntau Lawm (HTTA Axis Testosterone Ntau Lawm (HTTA PCTOr

○ Pittary txhawb:Los ntawm kev thaiv cov tshuaj estrogen lub tswv yim tsis zoo ntawm cov qog pituitary, uas tau tso tawm cov folthtary stimulating hormone (lh) .

○ LH / Fsh Surge:Tsa LH signalals cov kev xeem kom rov ua haujlwm ua kom rov qab tsim kev lag luam {}} fsh txhawb nqa spermatogenesis.

○ Cov sib xyaw ua ke:Tamoxifen tsis tshua siv ib leeg hauv PCT . nws yog qhov tshwj xeeb ntawm kev txhawb nqa fs (clomip), uas yog muaj tshwj xeeb tshaj plaws (clomip), uas yog muaj tshwj xeeb tshaj plaws (clomocifen 20mg /}}} qhov 10mg cov ntsiav tshuaj tso cai rau kev siv tau puv nrog cov kev cai lij choj (E .}}}}}}} .

● Cov estrogen tswj xaiv:Rau cov tib neeg uas muaj kev mob tshwm sim tseem ceeb ntawm AIS (zoo li kev sib koom tes loj, lossis kev cuam tshuam nrog tshuaj estse) tab sis tseem xav tau qee cov tshuaj esi}}}}}tej zaummuab kev sib haum xeeb . Nws pab thaiv cov kev ua mob estrogen hauv lub mis thaum tso cai rau cov tshuaj esi, muaj peev xwm mitigating {}}Qhov no tsis tshua ntseeg siab rau kev tswj cov tshuaj estrogen es tshuaj estrogen (zoo li dej khaws cia lossis ntshav siab) piv rau .

● Gyno Kev Tswj Xyuas:Kev tiv thaiv zoo heev thiab thim rov qab ntawm estrogenic gynecomastia - nws cov txiaj ntsig muaj zog tshaj plaws hauv cov ntsiab lus no.

Pct PC PC Effichacely:Zoo tsim los raws li kev sib xyaw ua ke ntawm cov menyuam yaus ua raws cov kev cai rau kev txhawb nqa HPTA rov. {}}

● Pob txha & Lipid Profile:Muaj peev xwm ib nrab neeg sawv cev cov txiaj ntsig ntawm cov pob txha ntxhia pob zeb thiab cov roj (cholesterol)tauUa kom muaj txiaj ntsig, tshwj xeeb tshaj yog cov cim kev noj qab haus huv thaum lub sijhawm no tab sis, tsis yog thawj qhov laj thawj rau siv.

● Cov tshuaj estrogen txo qis:Piv rau lub zog AIS (Aastrozole, letruzole), tamoxifen ua rau muaj kev txaus ntshai tsawg dua hauvlub kawCov qib tshuaj estrogen vim nws cov nqaij mos, muaj feem cuam tshuam txog kev pheej hmoo ntawm cov kev phiv tshuaj tsawg zoo li cov nqaij daim tawv nqaij tawv lossis mob lipid profile cuam tshuam}

MyHth busting:

○ Tsis txhob txo dej rov qab:Tamoxifen tsis muaj txiaj ntsig rau kev tswj hwm cov dej estrogen-cov dej tawm los yog ntshav siab}} AIS yuav tsum rau qhov .

○ Tsis txhob nce siab ncaj qha rau cov leeg rog lossis lub zog:Nws muaj xoom anabolic cov zog .}} Txhua qhov kev pab cuam los ntawm kev tiv thaiv tau los ntawm PCT (rov qab sim hauv PCT (rov ua haujlwm endogenous).

Tsis yog tus hloov AI tseem ceeb:Thaum qee zaum siv los ua lwm txoj hauv kev rau Gyno-nquag tus neeg nkag siab txog AIS, nws tsis tawm tsam cov ntshav siab estrogen qib zoo li ib qho tseeb .

● Gyno kev tiv thaiv (ntawm-voj voog):10mg txhua lwm hnub (EOD) lossis 10mg txhua hnub feem ntau yuav siv tau yog tias muaj ntxhiab tsw qab (20mg / hnub pib.

Gyno Reversal (thaum ntxov theem):20-40 mg / hnub yog ib hnub pib ua rau lub voj voog}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}

● Kev voj voog rau kev voj voog (PCT):Feem ntau ua ke nrog clomid .

○ Txuj Ci Qauv:Tamoxifen 20Mg / hnub (e .}}}}}}}} party {}}

○ Tsawg Koob / Siv Raws Cai:Qee tus neeg xaiv rau tamoxifen 10mg / day + clomid 25mg / deting {{3} {} lub lis piam, atting rau ib tug gentler tab sis txhawb nqa {}}

Sijhawm:PCT feem ntau pib pib 2-5 lub lis piamtom qabKev txhaj tshuaj kawg, nyob ntawm ib nrab-lub neej ntawm steroids siv (e {}} part} ntshiab .

● Cov txheej txheem tseem ceeb: "Yam tsawg kawg nkaus koob tshuaj"- Siv cov tshuaj qis uas muaj txiaj ntsig zoo qhov teeb meem (Gyn cov tsos mob lossis PCT kev xav tau)} {{{06g ntsiav tshuaj pab txhawb qhov no precision.

Ib nrab-lub neej:Tamoxifen nws tus kheej muaj lub davhlau ya nyob twg ib nrab-lub neej ntawm kwv yees li5-7 hnub{{0. Txawm li cas los xij, nws qhov tseem ceeb nquag metabolite,endoxifen, muaj ib nrab-lub neej ntawm14 hnub{{0. Qhov no yog qhov tseem ceeb tseem ceeb .

● Kev siv:

○ Lub xeev ruaj khov:Vim tias lub neej ntev-lub neej (tshwj xeeb tshaj yog ntawm endoxifen), nws yuav siv{{04-6 lub lis piam kom ncav nrog cov ntshav kom haumThaum pib kho kev kho .

○ Zaus:Txawm hais tias lub neej ntev-lub neej, kev noj tshuaj txhua hnub yog kev coj ua kom zoo ib hnub lossis sib cais txhua hnub (E {}}

Pct Ua timing:Lub neej ntev-lub neej yog aMuab ob npaug rau rab ntaj hauv PCT.

Inf:Thaum lub xeev khov kho tau mus txog (thaum ntxov hauv PCT), qib nyob ruaj khov nrog kev noj tshuaj txhua hnub .

◇ drawback:Tom qab cheem pcct, cov tshuaj thiab nws cov nquag metabolites nyob rau hauv lub system rau lub lim tiam .Qhov kev txhawb nqa no txuas ntxiv mus thaiv cov tswv yim estrogen feedback .Thaum qhov no pab tswj HTA stimulation pib tom qab cheem cov lus qhuab qhia, nwstaumuaj peev xwm pab txhawb rau kev ncua me ntsis, unsta cov lus qhia ntawm HTTAs li cas txawm li cas los xij, cov txiaj ntsig ntawm lub sijhawm PTCTIONS no theoretical kev txhawj xeeb .

Tamoxifen yoghauv pausRau feem ntau cov qauv niaj hnub niaj hnub no . nws lub luag haujlwm tsis tuaj yeem ua rau:

● Cov mechanism recap: Blocks estrogen negative feedback on the hypothalamus and pituitary -> Increases GnRH -> Increases LH/FSH ->Stimulates Leydig hlwb hauv kev sim los tsim testosterone thiab rov pib dua phev spermatogenesis .

EherTxawm nrog Clomid:Clomid (sib tov ntawm cov kab ke ntawm cov kab ke thiab zuclomhene) yog lub zog ua kom muaj zog ntawm fsh tso rau HTA axis .

● Tiv thaiv kev estrogenic rov qab:Tom qab cheem ib AI thaum cov qib tshuaj estrogen yuav ua kom rov qab cov ntaub ntawv ntawm cov kua muag ntawm qhov kev sib tw ntawm qhov tseem ceeb ntawm cov theem tseem ceeb tshaj plaws .

● Duration:{4-6 part yog txheem, tso cai rau lub sijhawm txaus siab rau cov khoom siv hapt ({} {0

● Kev soj ntsuam:Qhov zoo tshaj plaws, PCT kev ua tiav tau lees paub nrog kev ua haujlwm ntshav (testosterone, lh, fsh, estradiol) ob peb lub lis piamtom qabUa tiav PCC ua kom tiav kom ntseeg tau tias ib txwm muaj .

● Cov tshuaj noj:Tamoxifen yog ib qho tshuaj uas muaj cov tshuaj uas muaj cov tshuaj tseem ceeb {{} Kev noj tshuaj tus kheej nqa cov kev pheej hmoo ....

● Cov kev mob tshwm sim (lub cev nqaij daim tawv doses - 10-20 ml / hnub):

○ Ntau yam:Kub nrawm, tawm hws hmo, mob taub hau me, ceg cramps {}} ni.

○ Ocular:Tsis tshua muaj ceeb toom ntawm cataracts, retinopathy, lossis corneal hloov kho qhov muag qhov muag pom kev siv lub qhov muag tsis tu ncua nrog kev siv lub sijhawm ntev.

○ Cov teebmeem aideprial (txiv neej):Thaum tamoxifen kev ua ibtxawj txiv neejNyob rau hauv lub endometrium, cov ntaub so ntswg no tsawg kawg ntawm cov txiv neej . Cov xwm txheej tseem ceeb yog qhov teeb meem ntawm tus txiv neej endometrial teeb meem muaj (tsawg kawg nkaus).

○ Mus tau:Muaj peev xwm rau kev hloov pauv thaum lub siab, kev nyuaj siab, lossis qaug zog rau cov neeg tsis muaj kev kub ntxhov.

○ Dabtebtebism:Qw me nyuam me ntsis ntawm cov ntshav txhaws (DVT, cov kev pheej hmoo ua rau cov neeg muaj kev pheej hmoo (haus luam yeeb, kev rog, kev ua tau zoo siab "{}

Mob siab:Cov chaw tsheb ciav hlau nce (feem ntau me thiab thim rov qab); tsis tshua muaj mob hepatotoxicity .}} Saib xyuas lub siab enzymes tsis tu ncua .

○ Nrog kev sib cuam tshuam nrog progestins:Raws li tau hais, nws txoj kev ua hauj lwm ntawm progesterone receptorstej zaumtheoretically ua progestin-ntsig txog Gyno me ntsis ntau dua yog tias siv progestogenic steroids, txawm tias muaj pov thawj yog anecdotal tseem tawm tsam Estrogenic Gyno.

Tsis txhob hloov chaw rau lub nroog cycling:Tamoxifen tswj hwmqho casntawm steroid siv . Nws tsis tshem tawm cov kev pheej hmoo ntawm Anabolic Sterasoids, Lipid kev ntxhov siab, And30.

● Ib tug neeg teb:Caj dab tsi (CyP2D6 xwm txheej), tag nrho kev noj qab haus huv, thiab cov khoom sib xyaw / cov tshuaj uas siv tau cuam tshuam tseem ceeb.

Hom	Tus hma
Kev Lag Luam Npe	Nolcalx, Genox, Tamifen, TMX
Cas	10540-29-1
Tus hniav loj	371.515
Cov lus ntawm ib txoj kab ke	C26H29Tsis muaj
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	20mg * 100

 

 

Kev xav tau, thov hu rau peb

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Nolvadeex (Tamoxifen) 10mg ua haujlwm ob qho tseem ceeb, muaj pov thawj kev xaiv ua ntej rau ECHECOMATING SCIs-kev ua kom zoo dua qub nyob rau hauv cov ntaub so ntswg thiab txhawb HPTA rov qab.} Nws tsis yog lub panacea {} Txawm li cas los xij, nws tsis muaj txiaj ntsig zoo thiab nqa nws cov peev xwm tshwm sim thiab kev pheej hmoo . nws siv underscores txoj kev nkag siab zoo, tab sis nws cov ntawv thov kev txiav txim siab muaj kev txiav txim siab txog kev ua tau zoo {}}

Cim npe nrov: Stromusc NolvaSx (Tamoxifen) 10mg rau cas:} {}}}} {{} chaw tsim khoom, cov chaw tsim khoom, Hoobkas