HEPIUS Finasteride CAS: 98319-26-7

    Chemical Structure thiab Nomenclature

Cov tshuaj npe ntawm Finasteride yog N-(1,1-dimethylethyl)-3-oxo-4-aza-5-alpha-androst-1-en-17-beta - carboxamide. Nws muaj cov qauv molecular C23H36N2O2 thiab molecular hnyav 372.55 g / mol. Cov qauv qauv ntawm Finasteride qhia txog nws qhov xwm txheej zoo li steroid, uas yog qhov tseem ceeb rau nws kev cuam tshuam nrog 5-alpha reductase enzyme.

Keeb kwm keeb kwm thiab kev loj hlob

Finasteride yog tsim los ntawm Merck & Co., Inc. thiab tau pom zoo thawj zaug los ntawm FDA hauv 1992 rau kev kho mob ntawm BPH raws li lub npe Proscar. Tom qab ntawd, xyoo 1997, nws tau pom zoo rau kev kho mob ntawm androgenetic alopecia raws li lub npe Propecia. Txoj kev loj hlob ntawm Finasteride tau tsav los ntawm kev xav tau kev kho mob zoo rau cov xwm txheej no, siv kev nkag siab ntawm DHT lub luag haujlwm hauv lawv cov kab mob pathophysiology.

Molecular Structure thiab Formula

Finasteride yog ib qho 4-azasteroid compound, ze ze rau qhov tshwm sim steroids. Nws cov qauv molecular tso cai rau nws tshwj xeeb inhibit hom II 5-alpha reductase enzyme. Cov mis mos molecular C23H36N2O2 sawv cev rau nws cov tshuaj muaj pes tsawg leeg, thiab nws qhov hnyav molecular ntawm 372.55 g / mol yog raws li nws cov khoom zoo li steroid.

Solubility thiab Stability

Finasteride yog cov hmoov dawb mus rau dawb crystalline hmoov uas yog soluble hauv ethanol thiab methanol, tab sis tsuas yog me ntsis soluble hauv dej. Qhov profile solubility no cuam tshuam rau nws txoj kev tsim thiab kev tswj hwm. Cov ntsiav tshuaj Finasteride feem ntau yog tsim nrog cov khoom ntxiv uas txhim kho nws txoj kev ruaj ntseg thiab bioavailability.

Pharmacodynamics

Finasteride ua haujlwm los ntawm kev khi rau thiab inhibiting hom II 5-alpha reductase enzyme. Qhov inhibition no txo ​​qis kev hloov pauv ntawm testosterone rau DHT, ua rau txo qis hauv cov ntshav thiab cov ntaub so ntswg DHT. Qhov kev txo qis hauv DHT no txo ​​cov tsos mob cuam tshuam nrog BPH thiab androgenetic alopecia los ntawm kev txo qis prostate loj thiab cov plaub hau follicle miniaturization, feem.

Pharmacokinetics

Raws li kev tswj hwm qhov ncauj, Finasteride tau nqus los ntawm lub plab zom mov, mus txog qhov siab tshaj plaws ntawm cov ntshav ntshav hauv 1-2 teev. Nws muaj qhov ncauj bioavailability ntawm kwv yees li 80%. Finasteride yog metabolized feem ntau hauv lub siab los ntawm cytochrome P450 3A4 (CYP3A4) enzyme system. Nws cov metabolites raug tso tawm los ntawm cov zis thiab quav. Cov tshuaj pharmacokinetics ntawm Finasteride yog tus cwj pwm los ntawm nws qhov ntev ib nrab-lub neej, uas tso cai rau noj ib hnub ib zaug.

Cov ntawv thov kho mob

Kev kho mob ntawm Benign Prostatic Hyperplasia (BPH)

Finasteride feem ntau yog muab rau kev kho mob ntawm BPH, ib qho mob uas tshwm sim los ntawm lub caj pas prostate loj, uas tuaj yeem ua rau cov tsos mob tshwm sim xws li tso zis nyuaj, nce zaus, thiab ceev ceev. Los ntawm inhibiting DHT ntau lawm, Finasteride txo qhov ntim ntawm prostate thiab txo cov tsos mob no.

Kev kho mob ntawm Androgenetic Alopecia

Androgenetic alopecia, lossis txiv neej qauv baldness, yog lwm daim ntawv thov tseem ceeb ntawm Finasteride. Los ntawm kev txo qis DHT nyob rau hauv tawv taub hau, Finasteride tiv thaiv cov plaub hau ntxiv thiab tuaj yeem txhawb regrowth ntawm cov plaub hau hauv qee tus txiv neej. Nws yog tshwj xeeb tshaj yog zoo nyob rau hauv thaum ntxov theem ntawm cov plaub hau poob.

Kev siv daim ntawv lo

Finasteride tau raug siv tawm ntawm daim ntawv lo rau cov mob xws li hirsutism hauv cov poj niam, uas yog tus cwj pwm los ntawm kev loj hlob ntawm cov plaub hau, thiab ua ib feem ntawm kev kho tshuaj hormone rau cov poj niam hloov pauv. Nws txoj kev ua tau zoo thiab kev nyab xeeb hauv kev siv cov ntawv sau npe no tseem nyob hauv kev tshawb nrhiav.

Muaj peev xwm siv yav tom ntej

Kev tshawb fawb tseem tab tom tshawb nrhiav cov kev siv kho mob tshiab ntawm Finasteride. Kev siv yav tom ntej muaj peev xwm suav nrog kev kho mob qog noj ntshav prostate, vim tias txo qis DHT tuaj yeem pab cuam tshuam kev loj hlob ntawm qog noj ntshav, thiab ua ib feem ntawm cov txheej txheem kho mob rau lwm yam mob ntsig txog androgen.

Txo hauv Prostate Loj

Ib qho txiaj ntsig tseem ceeb ntawm Finasteride hauv kev kho BPH yog qhov txo qis hauv prostate loj. Qhov kev txo qis no txo ​​qis cov tsos mob tso zis thiab txhim kho lub neej zoo rau cov txiv neej uas raug mob los ntawm tus mob no.

Kev txhim kho hauv cov tsos mob tso zis

Los ntawm kev txo qis prostate loj, Finasteride txhim kho cov zis thiab txo cov tsos mob ntawm BPH xws li teeb meem pib tso zis, tsis muaj zog, thiab tso zis ntau zaus, tshwj xeeb tshaj yog thaum hmo ntuj.

Tiv thaiv plaub hau poob

Hauv kev kho mob ntawm androgenetic alopecia, Finasteride muaj txiaj ntsig zoo los tiv thaiv cov plaub hau ntxiv. Cov kev tshawb fawb soj ntsuam tau pom tias kev siv tas li ntawm Finasteride tuaj yeem cuam tshuam qhov kev loj hlob ntawm cov plaub hau thinning thiab poob hauv ib feem tseem ceeb ntawm cov txiv neej.

Kev txhawb nqa ntawm plaub hau Regrowth

Ntxiv nrog rau kev tiv thaiv cov plaub hau poob, Finasteride tuaj yeem txhawb cov plaub hau regrowth hauv qee cov neeg siv. Txawm hais tias tsis yog txhua tus txiv neej yuav ntsib qhov tseem ceeb regrowth, ntau tus neeg siv qhia cov plaub hau tuab thiab tuab dua tom qab siv ntev.

Pom zoo noj

Rau BPH

Cov koob tshuaj pom zoo ntawm Finasteride rau BPH yog 5 mg ib zaug ib hnub. Nws tuaj yeem noj nrog lossis tsis muaj zaub mov. Kev siv tas li txhua hnub yog qhov tseem ceeb rau kev ua tiav thiab tswj cov kev kho mob.

Rau Androgenetic Alopecia

Rau kev kho mob ntawm androgenetic alopecia, cov koob tshuaj pom zoo yog 1 mg noj ib zaug ib hnub. Zoo ib yam li BPH ntau npaum, nws tuaj yeem noj nrog lossis tsis muaj zaub mov, thiab kev siv txhua hnub yog tsim nyog los tswj nws cov txiaj ntsig.

Txoj kev tswj hwm

Finasteride yog siv rau qhov ncauj hauv daim ntawv ntsiav tshuaj. Cov ntsiav tshuaj yuav tsum tau nqos tag nrho thiab tsis cais los yog crushed. Qhov no ua kom muaj kev tso tawm kom raug thiab nqus ntawm cov tshuaj.

Lub voj voog ntev thiab cov qauv

Rau BPH, Finasteride kev kho mob feem ntau yog siv sijhawm ntev, feem ntau txuas ntxiv mus rau ntau xyoo. Rau androgenetic alopecia, kev kho mob yuav tsum tsis tu ncua, raws li kev tso tseg cov tshuaj feem ntau ua rau kev thim rov qab ntawm nws cov teebmeem hauv 12 lub hlis. Cov neeg mob yuav tsum ua raws li lub voj voog thiab cov qauv kom ua tiav cov txiaj ntsig zoo.

Absorption thiab ntshav ncig

Tom qab kev tswj hwm qhov ncauj, Finasteride tau nkag mus rau hauv cov hlab ntsha, mus txog qhov siab tshaj plaws ntawm cov ntshav ntshav hauv 1-2 teev. Cov tshuaj yog dav faib thoob plaws hauv lub cev, nrog rau cov prostate thiab tawv taub hau, qhov twg nws exerts nws cov teebmeem.

Metabolism thiab excretion

Finasteride feem ntau metabolized hauv lub siab los ntawm CYP3A4 enzyme system. Nws cov metabolites raug tso tawm hauv cov zis thiab quav. Kwv yees li 39% ntawm qhov ncauj koob tshuaj yog tawm hauv cov zis raws li metabolites, thaum cov seem yog tawm hauv cov quav.

Ib nrab-Lub Neej thiab Lub Sijhawm Ua Haujlwm

Lub davhlau ya nyob twg ib nrab-lub neej ntawm Finasteride hauv cov txiv neej hnub nyoog 18-60 xyoo yog kwv yees li 5-6 teev, thaum cov txiv neej hnub nyoog tshaj 70 xyoo, nws tuaj yeem txuas mus rau 8 teev. Qhov no ntev ib nrab-lub neej txhawb nqa ib zaug ib hnub. Lub sijhawm ua haujlwm yog txhawb nqa nrog kev siv txhua hnub, tswj kom txo qis DHT hauv cov ntaub so ntswg.

    Kev sib deev tsis zoo

Ib qho ntawm feem ntau tshaj tawm cov kev mob tshwm sim ntawm Finasteride yog kev sib deev dysfunction, nrog rau txo libido, erectile kawg, thiab txo ejaculation ntim. Cov kev mob tshwm sim no tshwm sim nyob rau hauv ib feem me me ntawm cov neeg siv thiab tuaj yeem tshwm sim txawm tias tom qab txiav cov tshuaj hauv qee kis.

    Psychological Effects

Qee cov neeg siv ntawm Finasteride qhia txog kev puas siab puas ntsws xws li kev nyuaj siab, kev ntxhov siab, thiab kev xav hloov pauv. Cov txheej txheem tseeb uas Finasteride tuaj yeem ua rau cov teebmeem no tsis nkag siab tag nrho, tab sis nws tseem ceeb rau cov neeg siv kom paub txog cov kev pheej hmoo no.

Kev cai lij choj thoob ntiaj teb

Finasteride tau pom zoo siv rau kev kho mob hauv ntau lub tebchaws thoob ntiaj teb, suav nrog Tebchaws Meskas, Canada, United Kingdom, thiab European Union cov tswvcuab xeev. Nws tsuas yog muaj los ntawm kev sau ntawv thiab raug tswj raws li cov tshuaj tswj hwm hauv qee qhov kev txiav txim siab.

Cov Kev Cai Tswj Kev Siv Kho Mob

Cov txheej txheem tswj hwm kev siv Finasteride suav nrog cov lus qhia tshwj xeeb, pom zoo noj ntau npaum li cas, thiab kev saib xyuas cov cai. Cov lus qhia no yog tsim los ntawm cov kws saib xyuas kev noj qab haus huv xws li FDA, EMA, thiab lwm lub koom haum tswj hwm hauv tebchaws kom ntseeg tau tias muaj kev nyab xeeb thiab siv tau zoo ntawm cov tshuaj.

Kev cai ua kis las

Finasteride yav dhau los tau suav nrog World Anti-Doping Agency (WADA) cov npe ntawm cov tshuaj txwv tsis pub vim nws lub peev xwm los npog kev siv cov tshuaj anabolic steroids. Txawm li cas los xij, nws raug tshem tawm ntawm cov npe hauv xyoo 2009. Cov neeg ncaws pob tseem yuav tsum paub txog cov kev cai ntawm lawv cov koom haum kis las txog kev siv Finasteride.

Kev tshawb fawb thiab kev tshawb fawb tam sim no

Kev tshawb fawb tam sim no ntawm Finasteride suav nrog kev tshawb fawb txog nws txoj kev nyab xeeb mus sij hawm ntev thiab kev ua tau zoo, muaj peev xwm siv tshuaj kho tshiab, thiab cov txheej txheem hauv qab nws cov kev mob tshwm sim. Cov kev sim tshuaj tsis tu ncua tab tom tshawb nrhiav kev siv Finasteride hauv ntau haiv neeg thiab cov xwm txheej.

Muaj peev xwm siv kev kho mob

Cov ntawv thov yav tom ntej ntawm Finasteride suav nrog nws siv hauv kev kho mob qog noj ntshav prostate, poj niam qauv plaub hau poob, thiab lwm yam mob ntsig txog androgen. Kev tshawb fawb tseem tab tom tshawb nrhiav kev tsim cov qauv tshiab thiab kev xa khoom los txhim kho nws cov txiaj ntsig thiab txo cov kev mob tshwm sim.

Kev tsim kho tshiab hauv Kev Tsim Kho Tshuaj

Kev tsim kho tshiab hauv kev txhim kho Finasteride thiab lwm yam sib xyaw ua ke txhawm rau txhim kho lawv cov tshuaj pharmacological. Qhov no suav nrog kev txhim kho ntawm kev xaiv 5-alpha reductase inhibitors nrog tsawg dua cov kev mob tshwm sim thiab kev tshawb nrhiav kev sib xyaw ua ke los txhim kho cov txiaj ntsig kho mob.

Hom	HEPIUS
Cov npe lag luam	Proscar, Propecia, Damocare, Finpecia, Finide, Fincar, Finax, Pronor, Finasteride
CAS	98319-26-7
Molar loj	372.549
Formula	C23H36N2O2
Purity	Tshaj 98%
Yam khoom	5 mg x 100

 

 

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Cov ntsiab lus tseem ceeb

Finasteride yog cov tshuaj siv dav siv rau kev kho BPH thiab androgenetic alopecia. Nws ua haujlwm los ntawm inhibiting kev hloov pauv ntawm testosterone rau DHT, ua rau txo qis hauv prostate loj thiab tiv thaiv cov plaub hau poob. Txawm hais tias nws cov txiaj ntsig, Finasteride cuam tshuam nrog cov kev mob tshwm sim, suav nrog kev sib deev thiab kev puas siab puas ntsws.

Kev txiav txim siab rau kev siv nyab xeeb

Txhawm rau kom muaj kev nyab xeeb ntawm kev siv Finasteride, nws yog ib qho tseem ceeb uas yuav tsum ua raws li cov lus pom zoo, ua raws li cov lus qhia kev tswj hwm, thiab saib xyuas cov kev mob tshwm sim. Cov neeg mob yuav tsum sab laj nrog cov kws kho mob txhawm rau txheeb xyuas qhov txaus ntshai thiab cov txiaj ntsig thiab tshaj tawm cov txiaj ntsig tsis zoo tam sim ntawd.

Cov kev cia siab yav tom ntej thiab kev txhim kho

Lub neej yav tom ntej ntawm kev siv Finasteride thiab kev tshawb fawb tuav cov lus cog tseg rau cov ntawv thov kho tshiab thiab txhim kho cov qauv. Cov kev tshawb fawb tsis tu ncua yuav txuas ntxiv txhim kho peb txoj kev nkag siab ntawm nws txoj kev ua tau zoo, kev nyab xeeb, thiab muaj peev xwm kho ntau yam mob. Kev tsim kho tshiab hauv kev txhim kho tshuaj yuav ua rau muaj txiaj ntsig zoo ntawm kev kho Finasteride, pab cov neeg mob thoob ntiaj teb.

Cim npe nrov: hepius finasteride cas:98319-26-7, Tuam Tshoj hepius finasteride cas:98319-26-7 manufacturers, lwm tus neeg, Hoobkas