Anastrozole 50mg Cancer Breast Cancer CAS: 120511-73-1

Anastrozole yog siv los kho cov tshuaj hormones thaum ntxov receptor-zoo mob qog noj ntshav mis. Nws kuj tseem siv rau kev kho thawj kab ntawm cov tshuaj hormone receptor-zoo lossis cov tshuaj hormone receptor-tsis paub txog qib siab lossis metastatic (mob qog noj ntshav uas tau kis) mob cancer mis. Anastrozole kuj tseem siv los kho mob qog noj ntshav siab uas tau loj hlob lossis kis tom qab kev kho tamoxifen. Cov tshuaj no tsuas yog siv rau cov poj niam uas twb tso tseg lawm (postmenopausal).

Ntau cov qog nqaij hlav cancer ntawm lub mis loj hlob hauv cov lus teb rau cov tshuaj estrogen. Cov tshuaj no cuam tshuam nrog kev tsim cov tshuaj estrogen hauv lub cev. Yog li ntawd, tus nqi ntawm cov tshuaj estrogen uas cov qog raug txo qis, txwv kev loj hlob ntawm cov qog.

Kev kho mob cancer mis: Anastrozole feem ntau raug kho los kho cov tshuaj hormone receptor-zoo mob qog noj ntshav mis. Cov hom qog nqaij hlav no muaj cov receptors rau estrogen lossis progesterone, uas tuaj yeem txhawb nqa lawv txoj kev loj hlob. Los ntawm kev thaiv kev tsim cov tshuaj estrogen, anastrozole pab qeeb lossis nres kev loj hlob ntawm cov qog nqaij hlav cancer no.

Hormone-Related Cancers: Anastrozole yog qhov zoo tshaj plaws rau cov poj niam postmenopausal vim nws ua haujlwm los ntawm inhibiting kev hloov ntawm androgens (txiv neej cov tshuaj hormones) rau hauv estrogen. Cov poj niam ua ntej poj niam cev xeeb tub feem ntau tsim cov tshuaj estrogen feem ntau hauv lawv lub zes qe menyuam, thaum cov poj niam postmenopausal cia siab ntau rau kev hloov pauv ntawm androgens rau hauv cov tshuaj estrogen hauv cov ntaub so ntswg peripheral.

 

 

 

Cov tshuaj hormones yog cov tshuaj uas peb lub cev tsim. Lawv ua raws li cov neeg xa xov liaison thiab pab tswj cov hlwb thiab cov kabmob ua haujlwm li cas. Cov tshuaj hormonal yog cov tshuaj uas hloov cov tshuaj hormones tsim los yog lawv ua haujlwm li cas hauv lub cev.

Ntau cov qog nqaij hlav hauv lub mis cia siab rau cov tshuaj estrogen (los yog estrogen) kom loj hlob. Qhov no yog hu ua estrogen receptor-positive (ER positive) cancer mis.

Anastrozole thaiv cov enzyme (ib hom protein) uas pab tsim cov tshuaj estrogen hauv cov ntaub so ntswg ntawm lub cev. Qhov no txo ​​cov tshuaj estrogen hauv lub cev.

 

 

Mus ntsib koj tus kws kho mob lossis tus kws saib xyuas kev noj qab haus huv kom kuaj xyuas koj qhov kev nce qib. Qhia rau koj tus kws kho mob lossis tus kws saib xyuas kev noj qab haus huv paub txog qhov txawv txav ntawm qhov chaw mos los ntshav.

Tsis txhob cev xeeb tub thaum noj cov tshuaj no lossis tsawg kawg 3 lub lis piam tom qab tso tseg. Cov poj niam yuav tsum ceeb toom rau lawv tus kws kho mob yog tias lawv xav xeeb tub lossis xav tias lawv yuav xeeb tub. Muaj peev xwm ua rau muaj kev phiv loj rau tus menyuam hauv plab. Tham nrog koj tus kws kho mob lossis kws muag tshuaj kom paub ntau ntxiv. Tsis txhob pub mis rau tus menyuam mos thaum noj cov tshuaj no lossis 2 lub lis piam tom qab tso tseg.

Cov tshuaj no yuav cuam tshuam rau kev muaj peev xwm muaj menyuam. Tham nrog koj tus kws kho mob lossis kws kho mob yog tias koj txhawj xeeb txog koj qhov kev xeeb tub.

Kev siv cov tshuaj no ntev ntev tuaj yeem ua rau muaj kev pheej hmoo ntawm cov pob txha qis. Tham nrog koj tus kws kho mob txog kev noj qab haus huv ntawm pob txha.

Koj yuav tsum paub tseeb tias koj tau txais calcium thiab vitamin D txaus thaum koj noj cov tshuaj no. Sib tham txog cov zaub mov koj noj thiab cov vitamins uas koj noj nrog koj tus kws kho mob.

 

 

Lub bioavailability ntawm anastrozole nyob rau hauv tib neeg tsis paub, tab sis nws tau pom tias nws yog absorbed zoo nyob rau hauv cov tsiaj.Absorption ntawm anastrozole yog linear ntau npaum li cas ntawm 1 mus rau 20 mg / hnub nyob rau hauv tib neeg thiab tsis hloov nrog rov qab tswj. Cov zaub mov tsis cuam tshuam rau qhov nqus ntawm anastrozole. Peak theem ntawm anastrozole tshwm sim nruab nrab 3 teev tom qab kev tswj hwm, tab sis nrog ntau yam ntawm 2 mus rau 12 teev. Steady-state theem ntawm anastrozole yog ua tiav nyob rau hauv 7 mus rau 10 hnub ntawm kev tswj xyuas tas li, nrog 3.5-fold tsub zuj zuj. Txawm li cas los xij, qhov kev txwv siab tshaj plaws ntawm qib estradiol tshwm sim hauv 3 lossis 4 hnub ntawm kev kho.

Active efflux ntawm anastrozole los ntawm P-glycoprotein nyob rau hauv cov ntshav-hlwb barrier tau pom tias txwv tsis pub lub hauv paus paj hlwb nkag mus rau anastrozole nyob rau hauv nas, whereas qhov no tsis yog nrog letrozole thiab vorozole. Yog li ntawd, anastrozole tej zaum yuav muaj peripheral selectivity nyob rau hauv tib neeg, txawm hais tias qhov no tseem tsis tau lees paub. Nyob rau hauv txhua rooj plaub, estradiol yog synthesized peripheral thiab nkag mus rau hauv cov ntshav-hlwb barrier, yog li anastrozole tseem xav tias yuav txo tau cov estradiol nyob rau hauv lub hauv nruab nrab lub paj hlwb mus rau ib tug tej yam degree. Lub plasma protein khi ntawm anastrozole yog 40 feem pua.

Cov metabolism hauv anastrozole yog los ntawm N-dealkylation, hydroxylation, thiab glucuronidation. Inhibition ntawm aromatase yog vim anastrozole nws tus kheej es tsis yog rau cov metabolites, nrog rau cov loj circulating metabolite yog inactive. [6] Kev tshem tawm ib nrab-lub neej ntawm anastrozole yog 40 mus rau 50 teev (1.7 txog 2.1 hnub). Qhov no tso cai rau kom yooj yim rau kev tswj hwm ib hnub. Cov tshuaj raug tshem tawm feem ntau los ntawm cov metabolism hauv lub siab (83 mus rau 85 feem pua) tab sis kuj los ntawm cov khoom seem tawm los ntawm lub raum tsis hloov pauv (11 feem pua). Anastrozole feem ntau raug tso tawm hauv cov zis tab sis kuj mus rau qhov tsawg dua hauv cov quav.

 

 

Ib txwm siv rau cov neeg laus koob tshuaj rau mob cancer mis:

Thawj koob tshuaj: 1 mg noj ib hnub ib zaug

Lub sij hawm ntawm kev kho mob: Kom txog thaum cov qog nqaij hlav (kev kho mob cancer ntawm lub mis loj heev); tsis paub (adjuvant kho mob cancer mis ntxov)

Kev siv:

-Adjuvant kev kho mob ntawm cov poj niam postmenopausal nrog cov tshuaj hormone receptor-zoo thaum ntxov mob qog noj ntshav;

-Cov kev kho mob thawj zaug ntawm cov poj niam postmenopausal nrog cov tshuaj hormone receptor-zoo lossis cov tshuaj hormone receptor tsis paub txog hauv zos qib siab lossis mob qog noj ntshav metastatic;

-Txoj kab thib ob ntawm kev kho mob qog noj ntshav hauv cov poj niam postmenopausal nrog cov kab mob kev loj hlob tom qab tamoxifen kho.

Koj noj nws ib hnub ib zaug, nrog lossis tsis muaj zaub mov. Sim coj nws tib lub sijhawm txhua hnub. Noj cov ntsiav tshuaj tag nrho nrog ib khob dej.

Yog tias koj tsis nco qab noj koj cov ntsiav tshuaj, noj koj cov koob tshuaj ntxiv li niaj zaus. Tsis txhob noj ob zaug.

Anastrozole yog kev kho mob ntev. Tej zaum koj yuav tau noj nws rau ntau xyoo. Koj tus kws kho mob, kws kho mob lossis kws muag tshuaj yuav tham nrog koj txog koj txoj kev npaj khomob. Ib txwm noj cov ntsiav tshuaj raws nraim li tau piav qhia. Qhov no yog qhov tseem ceeb kom paub tseeb tias lawv ua haujlwm zoo li qhov ua tau rau koj.

 

 

Hom	STADA
Khoom npe	Arimidex, Aremed, Anastrazole; anastrozol; ICI-D1033; ZD-1033
CAS	120511-73-1
Molar loj	293.374
MF	C17H19N5
Peev Xwm / Lub raj mis	1 mg x 50
Cov duab	Tablet

 

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Anastrozole yog cov tshuaj siv feem ntau siv rau kev kho mob ntawm cov tshuaj hormone receptor-zoo mob qog noj ntshav hauv cov poj niam postmenopausal. Nws belongs rau ib chav kawm ntawm cov tshuaj hu ua aromatase inhibitors, uas ua haujlwm los ntawm kev txo cov tshuaj estrogen hauv lub cev. Estrogen yog ib qho tshuaj hormones uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm qee hom qog nqaij hlav cancer mis. Los ntawm inhibiting zus tau tej cov tshuaj estrogen, anastrozole pab kom qeeb los yog nres kev loj hlob ntawm cov qog nqaij hlav cancer.

Thaum anastrozole muaj lub hom phiaj kho mob tshwj xeeb, nws kuj tau txais kev saib xyuas hauv kev tsim lub cev thiab lwm yam kev qoj ib ce vim nws lub peev xwm los tswj cov tshuaj estrogen. Qee tus kws tsim lub cev thiab cov neeg ncaws pob tuaj yeem siv anastrozole hauv kev sim txo cov tshuaj estrogenic cuam tshuam nrog kev siv anabolic steroid. Anabolic steroids tuaj yeem ua rau nce qib estrogen vim yog txheej txheem hu ua aromatization, qhov twg qee cov tshuaj steroids hloov mus rau hauv cov tshuaj estrogen hauv lub cev. Qhov no tuaj yeem ua rau muaj kev phiv xws li dej tuav, gynecomastia (cov ntaub so ntswg loj hauv cov txiv neej), thiab lwm yam teeb meem tshuaj estrogen.

Los ntawm kev txo cov tshuaj estrogen, anastrozole tuaj yeem pab cov neeg tsim lub cev tswj lossis tiv thaiv cov kev mob tshwm sim uas tsis xav tau. Txawm li cas los xij, nws tseem ceeb heev uas yuav tsum nco ntsoov tias kev siv anastrozole lossis lwm yam tshuaj rau lub hom phiaj uas tsis yog nws txoj kev siv kho mob tuaj yeem ua rau muaj kev pheej hmoo thiab muaj peev xwm tshwm sim. Kev siv tsis raug ntawm anastrozole los yog lwm yam aromatase inhibitors los ntawm bodybuilders tuaj yeem ua rau cov tshuaj hormones tsis txaus, tsis zoo rau kev noj qab haus huv, thiab muaj teeb meem kev cai lij choj.

 

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