STROMUSC Superior Quality Aicar 10mg Rau Lub Cev Muaj Zog CAS: 3031-94-5

    Nws Yog Dab Tsi: Tshaj li "Kev Ua Si hauv Pill" Daim Ntawv Sau

AICAR (5-aminoimidazole-4-carboxamide-1- -D-ribofuranoside) muaj nyob rau hauv ib qho chaw txawv txawv hauv ntiaj teb tsim lub cev. Nws yog ib tug nucleoside analog, ib txwm tshwm sim nyob rau hauv tib neeg lub hlwb, tsis tau lub version siv nyob rau hauv bodybuilding yog ib tug hluavtaws, tshawb fawb-qib tshuaj. Txhawm rau nkag siab txog nws qhov kev nyiam, koj yuav tsum xub nkag siab txog kev hloov pauv roj ntsha nws tig: AMP-activated protein kinase (AMPK). AMPK ua raws li lub cev tus tswv metabolic regulator. Thaum koj cov leeg nqaij sib cog lus thaum lub sij hawm qoj ib ce, cellular zog depletes, thiab AMPK activates kom rov qab zog tshuav nyiaj li cas los ntawm kev nce qabzib uptake thiab fatty acid oxidation.

Dab tsi AICAR ua yog tshuaj lom neeg lub xeev no. Thaum muab tshuaj, nws nkag mus rau hauv cov hlwb thiab yog phosphorylated rau hauv ZMP, ib qho chaw uas ua rau lub cev xav txog ATP (lub zog) tsawg, txawm tias tsis yog. Qhov kev siv tshuaj tshuaj no ntawm AMPK ua rau tib yam kev hloov pauv hauv metabolic raws li kev kawm ua siab ntev- yam tsis muaj qhov tseeb ntawm cov leeg nqaij. Pib tsim nyob rau hauv 1990s rau kev tshawb fawb cardioprotective thiab metabolic ntshawv siab, AICAR tau txais lub npe nrov hauv kev tsim lub cev hauv av tom qab qhov kev tshawb fawb 2008 los ntawm Ronald Evans pab neeg ntawm Salk Institute. Nyob rau hauv txoj kev tshawb no, cov nas uas nyob twj ywm txhaj tshuaj nrog AICAR tau khiav 44% ntev dua cov nas uas tsis kho, nplawm lo lus "kev tawm dag zog hauv ib ntsiav tshuaj".

Rau bodybuilders, superior zoo AICAR (feem ntau hais nyob rau hauv 10mg ntau npaum rau txhaj los yog qhov ncauj reconstitution) yog nrhiav tsis rau raw lub zog, tab sis rau nws muaj peev xwm los hloov cov nqaij fiber ntau muaj pes tsawg leeg, txhim khu cov roj oxidation, thiab muaj peev xwm ua raws li lub plawv mob ua tiav los ntawm relentless cardio.

Daim ntawv thov ntawm AICAR nyob rau hauv bodybuilding diverges ho los ntawm nws siv nyob rau hauv endurance kis las. Thaum cov neeg khiav dej num marathon yuav siv nws rau lub peev xwm aerobic, bodybuilders siv nws rau ob daim ntawv thov tshwj xeeb:rog poob khaws ciathiabglycogen supercompensation.

Thaum lub sij hawm txiav, bodybuilders feem ntau txwv cov carbohydrates kom deplete glycogen. Lub xeev no feem ntau ua rau cov leeg nqaij qaug zog thiab txo qis kev siv zog. AICAR daim ntawv thov no ua haujlwm kom nce GLUT-4 translocation (glucose transporters) thiab hexokinase kev ua haujlwm, ua kom cov leeg siv tau cov piam thaj me me uas zoo dua. Ib txoj kev tshawb fawb 2025 ntawm cov nas muaj hnub nyoog tau pom tias kev kho mob AICAR nce quadricep qhov hnyav li ntawm 8% thiab tetanic quab yuam tsim los ntawm 26.4% los ntawm kev txhim kho cov cim mitochondrial xws li cytochrome C. Rau ib tug bodybuilder nyob rau hauv ib tug caloric tsis txaus, qhov no txhais tau hais tias kom cov nqaij ntshiv thiab contractile quab yuam txawm tias tsawg zog muaj.

Qhov thib ob, AICAR yog siv nyob rau hauv cov hnub ua rau kev yees duab lossis kev sib tw. Los ntawm kev ua kom AMPK, nws ua rau muaj kev hloov pauv mus rau kev siv lipid. Nws tiv thaiv qhov inhibition ntawm fatty acid oxidation uas feem ntau tshwm sim thaum insulin thiab qabzib nce siab. Qhov no tso cai rau tus neeg siv kom haus cov carbohydrates rau cov nqaij ntshiv (glycogen loading) yam tsis muaj roj hlawv - metabolic "trick" uas pab ua kom qhuav, grainy zoo rau ntawm theem.

Cov txiaj ntsig tau hais los ntawm cov neeg txhawb nqa yog hauv paus hauv kev tswj hwm ntawm PPARδ co- activators thiab mitochondrial biogenesis. Thaum AMPK ua haujlwm tsis tu ncua, cov leeg tau txais fiber ntau - hom hloov. Hom IIb (ceev-twitch, glycolytic, qaug zog-nruab nrab) fibers pib qhia cov yam ntxwv ntawm Hom I (slow-twitch, oxidative, nkees-resistant) fibers . Rau ib tug bodybuilder, qhov no tsis txhais hais tias kev txi loj; es, nws txhais tau hais tias txhim kho kev rov qab los ntawm kev teeb tsa thiab lub peev xwm los tswj kev nro nyob rau hauv hnyav loads ntev dua.

Tsis tas li ntawd, AICAR ua raws li cov khoom noj muaj zog. Los ntawm kev nce AMPK, nws inhibits acetyl-CoA carboxylase (ACC), uas yog lub luag haujlwm rau hloov acetyl-CoA rau hauv malonyl-CoA. Thaum ACC inhibited, malonyl-CoA poob, uas tshem tawm cov nres ntawm carnitine palmitoyltransferase-1 (CPT-1). Qhov no tso cai rau fatty acids dej nyab lub mitochondria rau oxidation. Qhov tshwm sim yog qhov txo qis hauv cov lipid hauv cov hlab ntsha, uas tuaj yeem txhim kho cov tshuaj insulin rhiab heev thiab vascularity.

Kev tshawb fawb tsis ntev los no tseem qhia txog nws lub luag haujlwm hauv kev txo cov leeg nqaij. AICAR tau pom tias yuav txwv tsis pub qhia cov leeg nqaij - tshwj xeeb ubiquitin ligases Mafbx thiab Murf1- cov noob uas ua rau cov leeg nqaij atrophy . Qhov no tiv thaiv catabolic ib puag ncig yog qhov xav tau thaum lub sij hawm txhoj puab heev txiav qhov twg cortisol nce siab.

Kev txiav txim siab ntau npaum li cas rau AICAR yog qhov nyuaj vim tsis muaj tib neeg kev sim tshuaj rau kev ua tau zoo. Txawm li cas los xij, extrapolation los ntawm cov qauv tsiaj muab lub moj khaum. Cov kev tshawb fawb hauv cov nas tau siv ntau npaum li ntawm 500 mg / kg / hnub rau 1 mg / g ntawm lub cev hnyav. Rau tib neeg, qhov koob tshuaj no yuav txwv tsis pub kim thiab muaj peev xwm ua rau muaj tshuaj lom. Yog li ntawd, bodybuilding raws tu qauv yog micro-dosed los ntawm kev sib piv.

Rau qhov zoo tshaj plaws 10mg vials, cov txheej txheem raug suav nrog:

● Kev Siv:5mg rau 10mg muab ib zaug ib hnub.

● Kev tswj hwm:Kev txhaj tshuaj subcutaneous (rau hauv plab rog) lossis intramuscular (mus rau hauv deltoid lossis quadriceps) kom ua kom muaj kev noj qab haus huv ntau dua.

● Lub voj voog ntev:4a8 wb.

Tsis zoo li anabolic steroids, AICAR tsis ua haujlwm ntawm tus qauv receptor saturation; nws ua haujlwm ntawm txoj kev enzymatic. Nws yog feem ntau pulsed. Qee cov neeg siv siv "theem thauj khoom" ntawm 10mg ib hnub rau thawj ob lub lis piam kom saturate AMPK signaling, ua raws li kev saib xyuas theem ntawm 5mg ib hnub. Nws yog tsis tshua muaj siv standalone; nws yog feem ntau stacked nrog GW501516 (Cardarine) synergistically qhib ob qho tib si AMPK thiab PPARδ txoj hauv kev, tsim kom muaj zog endurance thiab rog- poob cocktail .

Ib nrab -lub neej ntawm AICAR hauv ntshav yog luv luv. Kev tshawb fawb qhia tias thaum qhov kev ua kom mob hnyav ntawm AMPK tshwm sim li ntawm 30 mus rau 60 feeb tom qab- txhaj tshuaj, cov kev hloov pauv hauv qab (mRNA qhia) txuas ntxiv ntev dua . Lub compound nws tus kheej muaj ib nrab ntawm - lub neej ntawm kwv yees li 30 mus rau 60 feeb, tab sis phosphorylation ntawm downstream lub hom phiaj tuaj yeem kav ntev li ob peb teev.

Muab qhov luv luv no ib nrab - lub neej, lub sijhawm yog txhua yam. Cov neeg siv feem ntau tswj hwm AICAR tam sim ntawd ua ntej ceev cardio lossis kev cob qhia. Qhov laj thawj yog tias kev ua kom muaj zog ntawm AMPK synergizes nrog lub ntuj AMPK nce los ntawm kev tawm dag zog, ua kom pom cov teeb liab rau mitochondrial biogenesis thiab rog oxidation. Kev tswj hwm AICAR hauv lub xeev pub noj (siab insulin) tuaj yeem ua rau nws qhov kev ua tau zoo, vim tias cov tshuaj insulin nyiam ua rau cov haujlwm AMPK.

Qhov no yog qhov twg AICAR deviates tag nrho los ntawm kev siv anabolic steroid. AICAR tsis txwv cov hypothalamic{1}}pituitary-gonadal (HPG) axis; Yog li ntawd, ib txwm siv PCT nrog SERMs zoo li Nolvadex lossis Clomid yog qhov tsis tsim nyog thiab tsis cuam tshuam rau kev rov kho cov testosterone. Txawm li cas los xij, lub tswv yim ntawm "PCT" rau AICAR tsom mus rau metabolic rov qab los.

Kev ua haujlwm ntev AMPK tuaj yeem cuam tshuam txoj hauv kev mTOR, uas yog thawj tus tsav tsheb ntawm cov leeg nqaij protein synthesis. Yog tias tus kws tsim lub cev ua haujlwm AICAR ntev dhau lawm, lawv muaj kev pheej hmoo tsim kom muaj qhov chaw metabolic uas nyiam oxidation tshaj anabolism. Yog li, "PCT" rau AICAR suav nrog:

1. Kev txiav txim siab:Tsuas txwv qhov sib xyaw ua ke, tso cai rau lub ntuj AMPK tawm tswv yim rov pib dua.

2.Nutritional Rebound:Kev noj zaub mov kom tsawg, tshwj xeeb yog carbohydrates, txhawm rau txhawb kev tso tawm insulin. Insulin yog ib tug natural antagonist ntawm AMPK. Ib puag ncig insulin ntau dua yuav pab kho mTOR rhiab heev thiab glycogen supercompensation.

3. Kev them nyiaj yug ntxiv:Siv cov tshuaj ntxiv xws li L-carnitine thiab coenzyme Q10 los txhawb cov mitochondrial ntom ntom uas tau tsim thaum lub voj voog, ua kom cov kev hloov pauv tau khaws cia txawm tias tom qab cov tshuaj tshem tawm.

Vim tias AICAR tsis yog ib qho tshuaj hormones, tsis muaj "kev sib tsoo" tshwm sim thaum tso tseg. Hloov chaw, tus neeg siv yuav pom qhov txo qis hauv plawv plawv thiab muaj peev xwm nce qab los noj mov, raws li AMPK ua rau hauv hypothalamus paub tias ua rau muaj kev tshaib plab.

Nws yog tsis yooj yim sua los tham txog AICAR yam tsis hais tus ntxhw hauv chav tsev: kev pheej hmoo. Lub Ntiaj Teb Anti-Doping Agency (WADA) txwv AICAR hauv xyoo 2009 nyob rau hauv chav kawm ntawm Hormone thiab Metabolic Modulators . Rau kev sib tw cev nqaij daim tawv, qhov kev sim zoo rau AICAR ua rau muaj kev rau txim loj.

Tshaj li kev cai lij choj, cov kev pheej hmoo kev noj qab haus huv muaj ntau heev. AICAR tsis pom zoo rau tib neeg kev siv tshuaj kho mob nyob txhua qhov chaw hauv ntiaj teb. 2024 xov xwm tshaj tawm los ntawm Radboudumc qhia tias AICAR yeej tsis dhau los ua cov tshuaj sau npe vim "ntau yam tshwm sim". Tsiaj cov qauv qhia tias kev ua kom AMPK ntau dhau hauv cov ntaub so ntswg uas tsis yog - tuaj yeem ua rau muaj kev puas tsuaj rau cov neurodegeneration thiab muaj peev xwm cardiotoxicity. Tsis tas li ntawd, vim tias AICAR ua haujlwm los ntawm kev hloov cov piam thaj metabolism, muaj kev pheej hmoo siab ntawm hypoglycemia. Cov neeg siv feem ntau qhia txog kev qaug zog hnyav thiab "hypoglycemic shakes" yog tias qhov ntau npaum li cas los yog tswj tsis tau cov carbohydrates txaus. Kuj tseem muaj kev txhawj xeeb txog kev sib sau ntawm ib txwm tshwm sim AICAR hauv lub cev tau txuas nrog cov kab mob metabolic.

Hom	STROMUSC
Cov npe lag luam	Aminoimidazole carboxamide ribonucleotide, AICA ribonucleotide, ZMP
CAS	3031-94-5
Molar loj	338.213
MF	C9H15N4O8P
Purity	Tshaj 98%
Yam khoom	10 mg x 100

 

 

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Superior zoo AICAR 10mg sawv cev rau kev txiav ntug-thiab qhov txaus ntshai heev- ntawm kev txhim kho metabolic hauv kev tsim lub cev. Nws tsis yog ib tug loj builder; nws yog metabolic re- qauv. Nws muab cov lus cog tseg theoretical ntawm kev txhim kho cov roj oxidation, txhim kho insulin rhiab heev, thiab qaug zog tiv thaiv uas ua rau muaj kev cuam tshuam txog kev ua haujlwm zoo. Rau bodybuilder, nws yog ib qho cuab yeej siv nyob rau hauv lub lis piam kawg ntawm kev npaj los tswj cov nqaij ntshiv thaum lub sij hawm stripping tawm intermuscular rog.

 

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