VARDENTAFILILILILILILIL RAU KEV KHO KEV KHO MUAB TAIS UA PHEM NTIAJ TEB NO: 224785-90-4

Dab tsi yog Vardenesafil? Dhau ntawm kev faib tawm yooj yim

Vardenafil yog lub zog thiab xaiv tau qhov ncauj phospholdiesterase Hom 5 (PDE5) inhibitor. Nws cov tub ntxhais lub tshuab tsom iav Lwm daim PDE5 inhibitors: nws tiv thaiv kom tawg ntawm guanos guanosphaate (CGMP) nyob rau hauv lub corpus cavernosum hauv nolis. CGMP yog qhov tseem ceeb intracellular signaling molecule ua rau teb rau kev sib deev thiab kev tso tawm ntawm nitric oxide (tsis muaj). Los ntawm kev nyob rau hauv PDE5, Vardgenafil tso cai CGMP theem tso cai, ua rau lub siab ntev ntawm cov leeg ntshav, thiab thaum kawg, ua kom ruaj khov thiab ua kom ruaj khovHauv kev teb rau kev sib deevCov. Qhov tseeb, nwstsis uantxias li erections; Kev sib daj sib deev tseem yog qhov tseem ceeb.

Tsim los ntawm Bayer thiab GlaxosmithKline, nws tau pom zoo los ntawm FDA hauv 2003 hauv lub npe coated ntsiav tshuaj) thiab tom qab ntawd raws li cov ntsiav tshuaj staxyn) - odt). Nws cov qauv tshuaj txawv txawv ntawm Sildenafil thiab Tadalafil, pab txhawb nws lub pharmacokasnetic thiab cov chaw muag tshuaj thiab cov chaw muag tshuaj.

Vardenafil qhov sib txawv nyob hauv ob peb tus nta tseem ceeb:

● Kev xaiv PDE5 Siab Siab:Vardenafil cov khoom pov thawj tshwjxeeb rau PDE5 hla lwm cov enzymes PDE (zoo li PDE6 hauv lub retina, cuam tshuam nrog Visual kev ntxhov siab). Qhov no txhais tau kom muaj peev xwm qis dua ntawm kev tawm- Lub hom phiaj zoo li xiav {{Tiav thiab mob taub hau thiab yaug qhov muag. Nws cov ntaub ntawv xaiv tau feem ntau suav nrog Kev Xaiv Nruab Nrab Nruab Nrab ntawm Sildenafil (tsawg dua xaiv) thiab nrog txawv ntawm {}} phiaj profile).

● Potency:Milligram rau Milligram, Vardenesafil yog feem ntau suav tias yog muaj zog dua li sildenafil, uas yuav tsum tau txo cov txiaj ntsig ntawm cov tib neeg. Qhov no tsis yog txhais tau tias nws yog "muaj zog" tag nrho "tag nrho" qhia nws txoj kev sib txawv.

● Dual daim ntawv:Vardenafil tsis sib haum nyob rau hauv ob daim ntawv thawj:

Waf Zaj Nkauj - co cotets (levitra):Cov Qauv Txheej Txheem Ntawm Qhov Dej Nrog Nrog Dej (5Mg, 10mg, 20MG cov zog).

○ Kev sib cais tawm cov ntsiav tshuaj (ODT - staxyn):Tsim los yaj sai ntawm tus nplaig tsis muaj dej (10mg lub zog). Qhov no muaj kev yooj yim, thiab muaj peev xwm nrawm dua rau qee qhov qhov ncauj mucosa, bypassing thawj zaug plab hnyuv ntxig. Bioavailability ntawm ODT yog me ntsis siab dua zaj yeeb yaj kiab - coated ntsiav tshuaj.

● Kev paub tias muaj qhov pib thiab sijhawm:Vardenafil feem ntau ua tiav cov tshuaj ntshav siab peak (tmax) tsis pub dhau 0.5 mus rau 1 teev Nws lub qhov rai zoo tshaj plaws vans 4 {{{{- 2 teev tom qab txhaj tshuaj ntawm sildenafil thiab lub sijhawm ntev ntawm tadalafil. Qhov no muaj cov kwv yees kwv yees "lub qhov rai ntawm lub sijhawm" rau kev npaj ua kev sib deev.

● Cov kev sib cuam tshuam:Thaum lub siab siab -} Cov zaub mov muaj roj tuaj yeem ncua thiab ua rau muaj kev sib haum xeeb (los ntawm cov yeeb yaj kiab)}} Qhov no ua rau Odt qhov kev xaiv zoo tshaj plaws rau cov neeg uas nyiam kom tsis tau sijhawm noj mov ib ncig noj mov.

● Kev pom zoo thawj zaug: Erectile kawg (ED):Vardenafil yog FDA -}} Pom zoo thiab dav siv thoob plaws hauv ntau yam etiologies (vascularic, psychogenic, lossis sib xyaw). Nws yog qhov ua tau zoo nyob rau hauv ntau ntawm cov neeg mob hnyav, suav nrog cov ntshav qab zib, thiab tus txha caj qaum yog qhov txo cov mob hnyav xws li cov kab mob vascular.

Kev tshawb nrhiav / tawm {- daim ntawv lo rau siv:

○ Arterial mob siab (PAH):Zoo li lwm PDE5 Inhibitors, Vardenafil tau kawm rau PAH. Thaum Sildenafil thiab Tadalafil muaj kev pom zoo tshwj xeeb thiab tsim qauv rau PAH, Versenfulfil's nyob rau hauv cov ntsiab lus no, feem ntau tau txiav txim siab thaum lwm txoj kev xaiv tsis haum lossis zam.

○ Raynaud qhov tshwm sim:Cov kev tshawb fawb tsawg qhia cov txiaj ntsig muaj txiaj ntsig muaj txiaj ntsig zoo rau kev txo qis ntawm cov zaus ntawm Vasppraste kev tawm tsam hauv Thawj Raymanet's, Leveraging nws vasodilatory siab.

○ Altitude Mob (Tiv Thaiv):Qee qhov kev tshawb fawb tshawb nrhiav PDE5 inhibitors, suav nrog kev tiv thaiv siab ntsws cuam tshuam, tab sis qhov no tsis yog kev coj ua.

Vardenafil muaj ntau cov kev pab sib txawv hauv PDE5 Inhibitor kawm:

● Muaj kev ua tau zoo nyob rau ntau haiv neeg:Pov thawj ua tau zoo nyob rau hauv ntau lub teeb meem ntawm ED cov laj thawj thiab kev loj heev.

Cov txiaj ntsig sab zoo cov khoom ntiag tug (Xaiv tau):Txo qhov tshwm sim ntawm PDE6-ntsig txog qhov muag pom kev pom zoo (zoo li lub zeem muag xiav xiav) piv rau sildenafil vim yog kev xaiv zoo dua.

● Kev yooj yim ntawm ODT cov qauv (staxyn):Qhov tseem ceeb rau cov neeg mob nrhiav kev txiav txim siab, cov uas tsis nyiam noj tshuaj, lossis cov uas tsis nyiam nqos tshuaj. Kev cuam tshuam cov zaub mov kom tsawg yog qhov txiaj ntsig tseem ceeb.

● Muaj kev paub txog, muaj lub sijhawm nruab nrab:Lub 4-5 teev lub qhov rai zoo muab lub sijhawm txhim khu kev qha rau kev npaj ua kev sib raug zoo uas tsis muaj lub sijhawm ntev (}}}}}}}}}}}}}}}}}}}}}}}}}}}

● Potency:Txo cov tshuaj tsis muaj peev xwm ua tau zoo sib piv rau cov tshuaj tiv thaiv kom ntau dua ntawm lwm tus neeg sawv cev, muaj txiaj ntsig rau cov nqi siv tau zoo ib yam nkaus xwb).

Peev Xwm Muaj Peev Xwm Rau Kev Dosing Txhua Hnub (Dose tsawg):Thaum tsis yog nws thawj zaug siv, qis dua, 5mg txhua hnub) tau tshawb nrhiav rau kev npaj mus txuas ntxiv, tab sis tsis tshua muaj tshuaj ntxiv uas yog tadalafil.

Kev txhaj tshuaj yog tus kheej thiab yuav tsum muaj kev saib xyuas kev kho mob:

● Pib txhaj tshuaj (Zaj duab xis - coated - levitra):Feem ntau 10mg coj ntawm siab, kwv yees li 25-60 feeb ua ntej xav tau kev sib deev. Dose tuaj yeem nce mus rau 20mg lossis txo qis rau 5mg raws li kev ua tau zoo thiab thev taus.

● Pib txhaj tshuaj (ODT - staxyn):10mg ntsiav tshuaj muab tso rau ntawm tus nplaig kom tawg tsis muaj dej. Tuaj yeem nqa nrog lossis tsis muaj zaub mov. Sij hawm yog zoo sib xws (25-60 feeb ua ntej kev sib deev). Tsuas yog 10mg lub zog muaj; Dose hloov kho tsis tau nrog ODT kev tsim ib leeg.

Dose Ntau tshaj plaws:20mg ib zaug txhua hnub rau zaj duab xis - co ntsiav tshuaj; 10mg ib zaug rau Odt.

Siv Zos Nta:Ntau ib zaug ib 24 teev.

Strose Kev Hloov Kho Tej Zaum:

○ Hnub nyoog:Cov neeg laus dua (ntau dua los yog sib npaug rau 65 xyoo) tej zaum yuav muaj kev sib kis tau ntau; Pib nrog 5mg zaj duab xis - txheej yog feem ntau pom zoo.

○ Hepatic Impactment:Nruab Nrab (Menyuam- phgh b) tsis txaus txo qis me ntsis. Max koob yog 5mg zaj duab xis-} coated los yog zam. Kev tsis ncaj ncees (tus me nyuam - phgh c) yog ib tug contraindication.

○ Tsis lees lees tsam:Me me mus rau kev mob tsis taus (CRCL 30-80 ml / min) feem ntau yuav tsum tsis muaj kev kho kom haum. Kev puas siab tsis txaus ntseeg (CRCL<30 mL/min) warrants caution; starting with 5mg film-coated and careful monitoring is advised; ODT not specifically studied.

Funcomitant tshuaj: Tseem ceeb, koob tshuaj tiv thaiv (piv txwv li, pib nrog 2.5mg zaj duab xis-}}}}, ritonavir, rithadromycin, clarafrompuit). Zam txhob siv nrog nitrates lossis Guanlate Cyclase stimulators (Riociguat) vim kev pheej hmoo hypotension loj. Alpha {{9- cov nroj tsuag xav tau kev ceev faj / sib cais ntawm cov koob tshuaj.

Vardenafil tsis siv nyob rau hauv ib txwm "kev voj voog" zoo li cov tshuaj scogolic. Nws yog ib qho ntawm -}} Xav tau tshuaj:

● On -}} Thov koob tshuaj:Tus qauv thiab feem ntau ua ke. Ib koob tshuaj ib zaug (5mg, 10mg, lossis 20mg zaj duab xis {}} coated, lossis 10mg odt) yog coj li ntawm 25-60 feeb ua ntej xav tau kev sib deev. Cov teebmeem tau tawm tswv yim rau hnub noj tshuaj.

● Txhua hnub qes - noj (tsawg dua):Thaum tsis yog nws thawj cov ntawv sau cia, qee qhov kev tshawb fawb thiab kev tshawb fawb koom nrog noj cov tshuaj tsis tshua muaj (} coated) ib hnub, tsis hais txog kev sib deev. Qhov no lub hom phiaj rau ntau qib kev kho kom zoo, pub rau spontaneity. Txoj hauv kev no tsis tshua tsim rau Vardenafil dua li tadalafil (uas muaj qhov tsawg tsawg {koob tshuaj pom zoo tso cai). Nws yuav tsum tau ua tib zoo xav txog tus nqi, tej zaum muaj peev xwm ntev-} kev phiv, thiab siv tshuaj sib cuam tshuam.

Ib nrab - lub neej (try):Kwv yees li 4 {{{- 5 teev rau ob qho yeeb yaj kiab {{4} co ntsiav tshuaj thiab ODT. Nov yog lub sijhawm nws yuav siv rau cov ntshav ntshav ntshav siab ntawm cov tshuaj kom txo tau ib nrab. Qhov no nruab nrab ib nrab-lub neej underpins nws siv sijhawm zoo ntawm 4-5 teev.

● Onset (Tmax):Cov tshuaj ntxuav ntshav siab tshaj plaws tau mus txog ntawm 0.5 {- 1 teev rau cov ntsiav tshuaj-coated ntawm 1 teev (thaj tsam 0.5-1.5 teev) rau qhov odt. Odt's nqus pib hauv qhov ncaujtauUa rau kom tau txais kev nrawm dua sai sai hauv qee tus neeg piv rau cov yeeb yaj kiab - coated version, tshwj xeeb yog noj nrog zaub mov.

● Retimination:Feem ntau metabolized nyob rau hauv daim siab ntawm Cytochrome P450 system (tsuas yog cyp3A4, me me txhawb los ntawm CYP3A5 thiab CYP2C isoforms). Cov metabolites yog excreted feem ntau yog nyob rau hauv quav (91-95%) thiab kom tsawg dua hauv cov zis (2-6%).

Vardenafil feem ntau muaj kev nyab xeeb thaum siv kom raug raws li kev kho mob tab sis muaj cov kev txwv tsis txaus siab thiab muaj peev xwm txaus:

● TEJ YAM TSIS TXAUS SIAB (TSIS TXHOB SIV):

Folomimitant nitrate kho:Txhua daim ntawv (subletual, tshuaj tsuag, thaj, pleev tshuaj pleev) lossis nitric oxide cov neeg pab nyiaj. Ua rau muaj txuj ci, lub neej - haj} hardening hypotension.

Jycomitant Guananlate Cyclase Stimulators (piv txwv li, Riociguat):Kev phom sij hypotension hypotension.

○ Paub Paub Txog Kev Mob Siab:Mus rau vardenafil lossis ib qho khoom tivthaiv ib qho ntawm cov qauv.

○ Decairment hnyav heev (tus me nyuam - pugh c).

○ Kawg-} theem raum raum rau cov kab mob uas yuav tsum tau lim ntshav (vim tsis muaj cov ntaub ntawv tsis muaj cov ntaub ntawv thiab cov peev xwm tsis muaj peev xwm).

○ Cov neeg rov ua haujlwm txawv txawv degenerative retinal disorders (piv txwv li, riginitis pigmentosa):Tsis -} Arteritic Anterior Anterior Neuric Neuropathy (Nees) tau tshaj tawm tsis tshua muaj PDE5 inibitors; Txoj kev pheej hmoo yuav tau nce nyob rau hauv cov uas muaj keeb kwm no.

● Cov Kev Ceev Faj Loj & Cov Lus Ceeb Toom (Siv Nrog Ceev Faj / Kev Tswj Xyuas Kev Kho Mob):

With ○ Tus kab mob plawv:Tsis yog rau kev siv rau hauv cov txiv neej rau tus neeg sib deev yog tsis ntev los no, piv txwv li Mi, lub neej tsis ruaj khov, lub neej-}<90/50 mmHg, uncontrolled hypertension >170/100 MMHG). Kev sim kev ntxhov siab yuav raug lav. PDE5 Inhibitors muaj cov hluav taws xob kub me me.

○ Prolonged Ereat / Passpism: Erections lasting >4 teev yuav tsum tau kho mob sai rau kev tiv thaiv kev puas tsuaj tas mus li thiab impotence. Txoj kev pheej hmoo yuav siab dua nyob rau hauv tus mob cell anemia, mob leukemia, ntau yam myeloma, penonie tsis zoo (Penronie's).

○ Thaum hnov ​​dheev:Tsis tshua muaj cov lus qhia ntawm kev txo qis lossis ploj ntawm lub rooj sib hais, qee zaum nrog tinnitus thiab kiv taub hau; Cegenality tsis tau tsim txhua, tab sis ceev faj cov lus qhia, tshwj xeeb yog nyob rau hauv cov uas muaj keeb kwm.

○ Qhov kev dag siab loj heev (CRCL<30 mL/min):Yuav tsum tau txais koob tshuaj kho thiab ceev faj.

And ○ Tsis kam (Menyuam - packgh b):Yuav tsum tau txais koob tshuaj Haum

○ Alpha - blockers:Muaj peev xwm tseem ceeb rau hypotension. Cais cov tshuaj sib txawv los ntawm tsawg kawg 6 teev; Pib Vardenafil tsuas yog tom qab tus neeg mob nyob ntawm alpha - blocker kho. Pib nrog qis qis tshaj plaws chaw tshuaj tiv thaiv koj tus kheej (2.5mg lossis 5mg zaj duab xis - txheej). Tamsulosin kev sib cuam tshuam yog tsawg dua tab sis ceev faj tseem qhia.Zam kev cuam tshuam nrog alpha - blockers.

○ Muaj pes tsawg tus cyp3A4 inhibitors:Tseem ceeb ntau vardenafil qib (AUC nce mus txog 10 -}}}}}} wold nrog Ketoconazole / Ritonavir). Max koob yog 2.5mg zaj duab xis - coated hauv 2400mg / hnub, itraconazole, ritonavir); Max 5Mg Zaj Duab Xis-Coated Nrog Rau Cov Hluav Taws Xob Uas Tsis Yooj Yim (Erythromycin, Ketoconazole 200mg / Hnub, Txiv kab ntxwv Subfruit).Zam kev cuam tshuam nrog muaj pes tsawg cyp3A4 inibitors.

○ Moderate CyP3A4 Yuam (piv txwv li, Efavirenz, Rifampin):Yuav txo qis chaw nrhiav kev ua tau zoo; Cov koob tshuaj ntau dua tuaj yeem xav tau ceev faj.

○ Los los ntshav / nquag peptic ulceration:Theoretical kev pheej hmoo; Ceevooj tau qhia.

○ Kev ua yeeb yam penmityKev phom sij ntau ntxiv.

Cov tsis zoo sib xws (feem ntau me -} xob moderate & semient):Mob taub hau (15%), yaug (11%), mob siab rau (9%), kiv cua), khaub thuas- zoo li cov tsos mob. Feem ntau tsis tshua muaj: Rov qab mob, myalgia, xeev siab, rhinitis. ODT yuav ua rau hloov pauv saj.

Testionity (overdose):Cov kev xav tau tshwm sim yog qhov kev cuam tshuam ntxiv ntawm cov kev phiv: kev mob siab, erection, syncope, muaj feem cuam tshuam. Kev Txhawb Nqa Kev Pab Yog Mainstay; Hemodialysis tsis muaj txiaj ntsig zoo vim muaj protein ntau los.

Kev Lag Luam Npe	Levitra, staxyn, vivanza
Cas	224785-90-4
Tus hniav loj	488.61
Cov lus ntawm ib txoj kab ke	C23H32N6O4S
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	Dawb crystalline hmoov

 

 

Kev xav tau, thov hu rau peb

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Vardenafil carves nws lub niche yog muaj zog thiab tsim nyog PDE5 inhibitor nrog cov qauv kev paub txog kev txiav txim siab thiab txo cov zaub mov sib cuam tshuam. Nws 4 {{- 5 teev lub qhov rais siv tau muab lub sijhawm txhim khu kev qha uas tau npaj siab ua tsis tau muaj kev cog lus ntev. Thaum sib koom cov txheej txheem tub ntxhais thiab ntau cov txiaj ntsig ntawm nws cov chav kawm, nws qhov kev xaiv txawv ntawm kev xaiv tau muaj txiaj ntsig zoo. Nws siv, txawm li cas los xij, xav kom ceev faj rau nws cov chaw muag tshuaj tshwj xeeb (tshwj xeeb yog nitrates), tshwj xeeb yog cov tshuaj yeeb yaj kiab (CYP3A4 inhibitors, alpha-blockers), thiab hepatic / raum / raum tsis taus. Cov ntawv sau tseg hauv Vardenafil kom nkag siab txog tus neeg mob cov kev noj qab haus huv thiab kev ua tau zoo, ua rau nws muaj txiaj ntsig zoo rau kev tswj hwm ed kev.

Cim npe nrov: Vardenafil rau kev kho cov CASFUNCTION CAS CASE CASE CAS: 224785-90-4, Tuam Tshoj Tuam Txhab Ua Phem Cas: 224785-90-4 tuam ntxhab, cov chaw tsim khoom, Hoobkas