Hmoov rau cov tshuaj loog hauv zos ua haujlwm: 59-46-1
Esting-esteering hauv zos, yog cov khoom siv tshuaj tua kab mob hauv zos
Taw qhia rau Propaine
Esting-esteering hauv zos, yog cov khoom siv tshuaj tua kab mob hauv zos Kev tsim kho lub cev ua yeeb yam thaum pib ntawm kev ua yeeb yaj kiab hauv zos zoo li Lidocaine {}}}}} Cov kev sib tw keeb kwm thiab keeb kwm keeb kwm.
Tshuaj kho tshuaj thiab kev ua haujlwm ntawm kev nqis tes ua
Lub (c₁₃h₂₀n₂o₂) yog muab tau los ntawm para-aminobenzoic acid (paba) thiab dienhlaminoThaum loj. propaine blocks voltage-gated sodium Raws, inhibiting hlab ntsha impulse . nws ua yog pep-dependent; hauv acidic ib puag ncig (e {{6} g {}} Cov nqaij mos), ionization txo qhov kev ua tau zoo, tsis pom cov neeg sawv cev tshiab.
Cov Nta Sib Txawv
● Ester faib: Cov metabolism ceev dua los ntawm cov ntshav ntshav ntshav qab zib me me tab sis nce txhua lub peev xwm tab sis zam txhua yam vim Kaba metabolites .
● Lub sijhawm luv luv: Siv tau rau 30-60 feeb, zoo tagnrho rau cov txheej txheem luv luv {2 2}}
● Tsawg potency: Yuav tsum muaj kev sib zog ntau dua li cov kev ua kom loog rau kev ua tau zoo .
● Vasodilatory: Txhim kho kev nqus tau yooj yim, feem ntau yuav tsum vasoconstrictors zoo li epinephrine mus rau ntev ntev .
Cov Ntawv Thov Kev Kho Mob
● Kev kho hniav: Keeb kwm keeb kwm, kev siv thawj zaug rau cov hniav tawm thiab kab noj hniav npaj .
In In Infiltration Actionhesia: Kev phais me me lossis suturing .
● Kev kuaj mob thaiv: Kev cuam tshuam ib ntus ib ntus (e {{{{} g}}}}}} {.
● Kev siv kho tsiaj: Nyiam nyob rau hauv cov tsiaj rau cov txheej txheem luv luv vim kev tshem tawm sai .
Sib txuas ua tus txha caj qaum: Tsis tshua muaj, ua ke nrog lwm tus neeg sawv cev rau cov kabmob spinity .
Cov txiaj ntsig thiab cov txiaj ntsig zoo
● Kev ruaj ntseg profile: Qis dua cardiotoxicity muaj kev pheej hmoo ntau xws li bupivacaine .
● Cov metabolism sai sai: Txo qhov kev pheej hmoo ntawm kev pheej hmoo ntawm kev lom zem, zoo rau cov neeg mob uas muaj mob hepatic tsis meej .
● Them nyiaj zoo: Econical hauv cov peev txheej-txwv kev ntsuas .
● Cov tseem ceeb keeb kwm tseem ceeb: Lub hauv paus rau kev nkag siab txog cov tshuaj loog hauv zos .
Muab thiab tswj hwm
● Kev siv hniav: 1-2% daws (txog li 500 mg rau ib ntu) nrog epinephrine (1: 200, 000
● Infiltration: 0 {. 25-0.5% daws, max 7 mg / kg (cov laus).
● Kev kho kev hloov pauv pediatric: Dose txo raws li qhov hnyav (1 .}} 5 mg / kg).
● Cov ntsiab lus: Ua txhaum rau Esters, pseudocholinestase tsis muaj peev xwm, lossis kis tus kab mob ntawm cov chaw txhaj tshuaj .
Pharcerminetic kev voj voog
Kev Txhim Kho: OVSET tsis txaus ntseeg (2-5 feeb) tab sis luv luv vim yog Vasodation .
● Cov Distry: Txwv rau cov kua dej ntxiv; Tsawg protein khi .
● Metabolism: Hydrolyzed los ntawm Ntshav Crafe Care rau hauv kaba thiab diethylaminoethanol .
● Excretion: Lub raum tshem tawm ntawm cov metabolites; 80% tshem tawm hauv 24 teev .
Ib nrab-lub neej thiab kev txiav txim siab metabolic
● Ib nrab-lub neej: 40-80 vib nas this nyob rau hauv cov ntshav, ntev hauv pseudocholinesases muaj faignices (caj ces los yog kis tau).
● Kev sib txuas lus sib txuam: SccinylCholcholcholine thiab Ester metabolism qhia cov enzymes, pheej hmoo ntev ntev neuromuscular blockade yog tias.
Chaw hais txog PTC (Plasma sijhawm-siab nkhaus)
Thaum "PTC" tsis yog lub sijhawm kws ua tshuaj, kev txhais lus hais qhiaPlasma Time-concentration nkhaus, nthuav dav kinetics kinety . Kev txhaj tshuaj
Kev txom nyem thiab kev tswj
● Cov kev ua xua: Pob xoo los yog anaphylaxis los ntawm Paba rhiab li .
● Cns Toxicity: Tsawg ntawm cov tshuaj kho; Cov koob tshuaj ntau ua rau kiv taub hau lossis qaug dab peg .
● Cardiovascular cuam tshuam: Hypotension los ntawm vasodilation los yog ncaj qha Myocardial Kev Nyuaj Siab .
● Kev tswj: Kev txhawb nqa cov pa hluav taws xob rau qhov hnyav; lipid emulsion rau overdose .
Kev Tshawb Fawb piv nrog cov tshuaj loog nimno
● Lidocaine: Siv sijhawm ntev dua, kom ntev dua, tsis muaj kev txwv tsis pub muaj (cov pab pawg noj) .
NOJ Bupivacaine: Cim tseg lub caij nyoog ntev, ntau dua cardiotoxicity .
● Articaine: Enhanced ntaub so ntswg nkag, nyiam hauv cov kho hniav .
Kev nrhav thiab cov xwm txheej tam sim no
Thaum lub sij hawm ntau yam khoom siv, propaine pom Niche test:
● Propaine Penicillin: Cov tshuaj tua kab mob qeeb: .
Kev tshawb fawb qhov mob ntawm kev mob neuropathic: Kev tshuaj xyuas kev siv hauv MineBrance stabilization .
● Koobmethation Dermatology: Ua ke nrog botulinum toxin rau kev txo qhov tsis xis nyob.
Cia thiab Ruaj Khwv
● Cia: Tiv thaiv los ntawm lub teeb nyob rau hauv cov thawv airtight; nyob ruaj khov nyob rau hauv chav tsev kub .
● Moved lub neej: 2-3 xyoos; nag lossis daus qhia txog kev tsis txhob txwm ua rau .
Cov ntaub ntawv kho mob
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Kev Lag Luam Npe |
Benzoic acid, {4- Amino-, 2- (diethylamino) tus neeg txawj ntse; {{04- Aminobenzoic acid 2- i} diethylasethyl ester; Procaine; novocaine |
|
Cas |
59-46-1 |
|
Tus hniav loj |
236.315 |
|
Mf |
C13H20N2O2 |
|
Kev coj dawb huv |
Saum toj no 99% |
|
Kev tsim nyog |
Cov muaju dawb muaju |
Kev xav tau, thov hu rau peb
Email: Jasonraws106@gmail.com
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Tag
Kev txhim kho cov legacic niaj hnub no {}} nws tau txais kev nyab xeeb rau kev siv tshuaj kho thiab kev kawm .
Cim npe nrov: Hmoov tsis zoo rau kev ua yeeb yam hauv zos: {{{}}}}}, Tuam Tshoj procaine acteshesia CAS:}} cov chaw tsim khoom, cov chaw tsim khoom, Hoobkas
