Exemestane (aromasin) rau kev ua haujlwm ntawm lub cev ({107868-30-4
Exemestane, ua lag luam raws li Aromasin, yog steroidal aromatase inhibitor (ai) feem ntau siv hauv kev kho mob cancer mis. Nyob rau hauv kev tawm tsam lub cev, nws yog ib tug lais-daim ntawv lo los tswj cov kev mob estrogen-cuam tshuam los ntawm anabolic steroid siv. Cov lus qhia no rho tawm mus rau hauv nws cov khoom ntiag tug, kev siv, thiab kev coj ua zoo rau cov neeg ncaws pob nrhiav kev ua tau zoo thaum tsis tshua muaj kev phom sij thaum tsis muaj kev phom sij.
Dab tsi yog exemestane hmoov?
Exemestane yog cov hluavtaws formastane derreversible uas irr ...Measly inhibits aromatase enzyme, ib qho catalyst rau kev hloov pauv Androgens xws li testosterone nyob rau hauv estsosen. Tsis zoo li tsis-steroidal ais (piv txwv li, exemestane's steratase ua rau nws mus khi mus tas li, khwv tau nws lo lus "suicidal inibitor." Muaj nyob rau hauv cov ntsiav tshuaj lossis cov hmoov tawv nqaij nyoos, cov hmoov variant yog cov ua haujlwm ntawm lub cev ua haujlwm ntawm lub cev muaj txiaj ntsig zoo thiab kev ua kom zoo nkauj. Txawm li cas los xij, nws cov xwm txheej tsis muaj kev pheej hmoo, suav nrog kev txhawj xeeb huv siab thiab kev ntsuas tsis muaj tseeb.
Tus tseem ceeb mis cov nta
● Cov mis molecular: C₆h₇cln₂o
● Pom: Cov hmoov dawb dawb
● Solubility: Lipophilic, Xav tau cov kuab tshuaj organic rau kev xaus.
Txaus siab: Degrades nyob rau hauv UV teeb, tsim nyog airtight, lub teeb-resistant cia.
Mechanism ntawm kev nqis tes ua: dhau ntawm cov tshuaj estrogen
Exemestane thawj lub luag haujlwm yog txhawm rau txhawm rau curthoen synthesis, tab sis nws muaj kev cuam tshuam rau kev ua kom lub cev yog multifaceted:
● Cov tshuaj tswj hwm estrogen: Tiv thaiv cov dej khaws cia thiab Gynecomastia ("Gyno") thaum mus ncig.
Ste Tshuaj Testterosterone-rau-Estrogen Piv: Los ntawm kev txo qis estrogen, nws tsis ncaj nrov nrov dawb testosterone, txhim kho cov leeg loj hlob thiab rov qab.
● Cortisol Tes Haujlwm: Cov kev tshawb fawb tshwm sim tawm tsam AIS yuav txo cortisol, cov tshuaj catabolic mypone, txawm tias muaj pov thawj tseem tsis tau ua.
Irreversible khi: Tsis zoo li reversible AIS, exemestane cov cuam tshuam tsis ntev los txog tshiab aromatase enzymes yog synthesized (3-5 hnub), tso cai ntau nquag noj tshuaj.
Cov ntawv thov hauv kev ua haujlwm ntawm lub cev
a. Cov kev tswj hwm ntawm kev tswj hwm
Lub sijhawm tshuaj steroid (piv txwv li, testosterone, dianabol), ntau dhau teatosterone aromatizes rau estrogen, ua rau cov kev mob tshwm sim, ua rau cov kev phiv. Kws zoo tshaj plaws mitigates:
● Gyno tiv thaiv: Blocks estrogen khi rau cov kua mis tso tawm.
● Cov leeg txhais lus: Txo cov dej hauv qab subcutaneous, txhim kho vascularity.
● Lipid Tshuav Nyiaj: Counteracts steroid-inducts hdl supression, txawm hais tias expeoleane nws tus kheej yuav mob mentsis tuaj yeem cuam tshuam cov lipids.
b. Tom qab kev cobqhy (Pct)
Kev voj voog tom qab, cov tes testosterone ntau lawm tau tsim txom. Cov Kws Tshaj Lij Exemestane Aids PCCT los ntawm:
Tiv thaiv kev estrogen rebound: Tam sim ntawd AI rho tawm tuaj yeem tuaj yeem ua rau cov tshuaj tua hluav taws; Exemestane qhov kev tshem tawm maj mam txo qhov no.
E● Noj cov lus qhuab qhia: Ua ke nrog clomid lossis nolvadex, nws pab kho hypothalic-pituitarian-piticular-laeticular axis (HPTA) muaj nuj nqi.
c. Txiav lases
Cov neeg ncaws pob siv tus yam ntxwv tsis zoo rau kev txiav tawm thaum txiav txim siab tias nws cov tshuaj tua hluav taws rau kev ua rog, txawm tias qhov no yog kev pheej hmoo thiab phom sij estrogen deficiency.
Cov txiaj ntsig dhau ntawm compounding ais
● Potency: 25MG ntawm exemestane ≈ 1mg ntawm anastrozole hauv kev ua tau zoo.
● Ib nrab ntawm lub neej Synergy: {{24- teev ib nrab teev ib nrab-lub neej ua kom haum rau cov koob tshuaj txhua hnub, ruaj khov cov txheej txheem kev ruaj khov.
● Mineralocorticoid sparing: Tsis zoo li litrozole, nws tsis cuam tshuam alderoterone, txo kev pheej hmoo txaus ntshai.
● S Androgenic Backdoor: Nws cov qauv ntse Androstane yuav ua rau tsis muaj zog khi thiab recetors, muab cov kev ua haujlwm tsis zoo rau Anabolic.
Ntsej Muag Dosage
a. Cov Qauv Tshuaj
Kev voj voog: 12.5-25mg txhua hnub, hloov tau los ntawm lub voj voog thiab ntsuas cov ntshav (tsom rau 20-30 PG \/ ML).
Ntsiab lus PC PC: 12.5mg txhua lwm hnub rau 2-4 lub lis piam, paired nrog cov lus qhuab qhia.
b. Hmoov-kev txiav txim siab
● Muaj kev ntsuas yog: Siv Milligram nplai kom tsis txhob muaj nyob rau hauv \/ overdosing.
● Solubility txoj kev sib tw: Raug tshem tawm hauv ORA-PLUS lossis PEG -400} kom sawv rov qab.
c. Kev Siv Kev Siv GENender
Cov poj niam ncaws pob zam kev exhemestane vim muaj kev pheej hmoo ntawm volilization thiab hormonal tsis txaus.
Lub voj voog kev sib xyaw: kev kawm
Piv Txwv 1: Testosterone Ua Ntej
● Lub lis piam 1-12: Kuaj e (500mg \/ lub lim tiam) + exemestane (12.5mg \/ hnub).
● Qhov tshwm sim: Txo bloat, tswj libido, thiab LDL \/ HDL piv nyob rau hauv 3: 1.
Piv Txwv 2: Post-Deca-Durabolin Pct
● Lub lis piam 1-4: Clomid (50mg \/ day) + exemestane (12.5mg EOD).
● Qhov tshwm sim: Perchatosterone rov qab rau lub hauv paus hauv 6 lub lis piam, tsis muaj tshuaj ntsuab.
Pharmaconinetics: Ib nrab-lub neej thiab metabolism
● Ib nrab-lub neej: ~ 24 teev, txhawb nqa ib zaug noj tshuaj txhua hnub.
● Metabolism: Hepatic, ntawm CYP3A4. Inhibitors (piv txwv li, kua txiv kab ntxwv qaub) muaj peev xwm nce qib ntshav.
● Excretion: Senal (42%) thiab quav (42%).
Kev phom sij thiab cov kev mob tshwm sim
● Cov hluavtaws sib tsoo: Cov tsos mob xws li mob pob txha, kev nyuaj siab, thiab lipid profile detioration.
Androgenic Phem: Pob txuv lossis plaub hau hauv cov plaub hau uas muaj plaub hau.
● Kev ntxhov siab hepatic: Tsis tshua muaj, tab sis kev siv ntev ua rau daim siab soj ntsuam.
Cov tswv yim Kev Pab Nkhaus: Pib nrog cov tshuaj qis qis (6.25mg), ua ntej cov ntshav ua haujlwm, thiab ntxiv nrog omega {2} s rau kev txhawb nqa lipid.
Kev Txiav Txim Siab thiab Kev Txiav Txim Siab
Kws lij choj Exemestane yog tshuaj-tsuas yog nyob rau hauv feem ntau lub teb chaws. Cov neeg ncaws pob uas muaj cov hmoov ua kom muaj kev pheej hmoo txaus ntshai thiab cov khoom ua tub ntxhais. Kev coj ncaj ncees, nws daim ntawv lo siv tsis pub lwm tus xav tau kev kho mob kom sib npaug cov hom phiaj rau kev noj qab haus huv.
Myths vs. kev muaj tiag
● Myth: "Exemestane BoostS Testerosterone."
Kev muaj tiag: Nws indirectly tsa dawb testosterone los ntawm kev txo cov tshuaj estrogen txoj kev tsuj ntawm HTA.
● Myth: "Ntau dua ai sib npaug zoo dua."
Kev muaj tiag: Tshaj dhau Ai tsoo cov tshuaj estrogen, tsis txaus siab rov qab thiab kev noj qab haus huv plawv.
Cov ntaub ntawv kho mob
|
Kev Lag Luam Npe |
Aromasin, FCE -24304 |
|
Cas |
107868-30-4 |
|
Tus hniav loj |
296.410 |
|
Cov lus ntawm ib txoj kab ke |
C20H24O2 |
|
Kev coj dawb huv |
Saum toj no 98% |
|
Kev tsim nyog |
Dawb crystalline hmoov |
Kev xav tau, thov hu rau peb
Email: Jasonraws106@Gmail.com
Whatsapp: +86-15572565525
Telegram: +86-19128233885
Tag
Exemestane hmoov muaj cov kev ua kom lub cev lub cev muaj zog rau cov tshuaj estrogen tab sis xav tau kev hwm rau nws cov kev pheej hmoo. Ua ntej noj tshuaj, kev saib xyuas ntshav, thiab kev cai lij choj hauv qab. Thaum kawg, kev noj qab haus huv-nco ntsoov ua kom ntseeg tau txoj kev vam meej hauv kev ua tiav daim physique cov hom phiaj. Yuav tsum tau sab laj cov kws kho mob kom paub txoj kab zoo ntawm kev txhim kho thiab kev tsim txom.
Cim npe nrov: Exemasin (Aromasin) Rau Cas BodyBuilding CAS: {{}}}}} {{{} Cov kws tsim khoom, cov chaw tsim khoom, Hoobkas
