Phenacetin rau daws cov mob ua txhaum: 62-44-2

Cov Ntsiab Lus Keeb Kwm thiab poob

Phenacetin, ib zaug pob zeb ntawm analgesic kev kho, tshwm sim nyob rau hauv lub xyoo dhau los ua kev nyab xeeb rau kev tswj hwm qhov mob Cov tshuaj ntsuab sib xyaw ua ke, feem ntau ua ke nrog cov tshuaj aspirin thiab ua kom muaj ca,} siv, kos cim ib lub sijhawm pivotal hauv photacovisisigilance keeb kwm .

Tus qauv:Phenacetin (c₁₀h₁₃no₂) belongs rau Para-Aminophenol chav kawm, ua haujlwm sib thooj rau cov neeg ua haujlwm hauv lub ntsej muag kom zoo rau cov tshuaj tua kab mob {} Cov metabolite he .

Cov kev ntsuas metabolic:

● Ntu 1:Demethylation los ntawm cytochrome p450 hloov phenacetin rau acetaminophen .

● Ntu 2:Glucuronidation thiab sulfation ua kom yooj yim ua kom dimcetion .
Ib txoj kev me me ua rau muaj cov tshuaj lom neeg lom zem xws li P-Phenetidine zoo li p-phenetidine kev ntxhov siab thiab kev tsis txaus siab rau oxidobinemia.

Mechanism ntawm Kev Ua:
Phenacetin inhibits prostaglandin synibes in the central system los ntawm tsis zoo li NSIPLOOKY ARSRAMARATION, ua rau nws tsis muaj txiaj ntsig zoo rau kev mob siab rau inflammidation .

Pom cov txiaj ntsig (keeb kwm keeb kwm):

● Ceev xwm ceev:Relieved me-rau-mob mob (mob taub hau, neuralgia) tsis pub dhau 30-60 feeb {}}}

● Hnov kev ua siab ntev:Tsawg dua ulperogenic dua aspirin, zoo tagnrho rau kev siv mob ntev .

Ultantipyretic efficacy:Txo kev kub taub hau yam tsis muaj kev cuam tshuam nrog electrolyte sib npaug .

Txwv:

Tsis muaj kev txiav txim siab los tiv thaiv:Kev tsis haum xeeb rau kev mob caj dab lossis kev raug mob uas cuam tshuam .

Strose Tshuaj lom neeg lom zem:Kev siv ntev nrog kev sib haum nrog lub raum paposary necrosary thiab urothelial cancer .

Daim Ntawv Thov Keeb Kwm:

● Monsotherapy:Siv rau migraines, dysmenorrhea, thiab tom qab phais mob.

● Cov Qauv Ua Yeeb Yam:APC cov ntsiav tshuaj (aspirin 250 mg, phenacetin 150 mg, caffeine 50 mg) lub hom phiaj synergistic mob nyem {}}

Ntiaj teb kev cai hloov pauv:

    ●1953:Switzerland tshaj tawm thawj zaug ntawm "analgesic nephopathy" txuas rau phenacetin .

    ●1971:Leej twg faib nws li carcinogenic, kev tshoov siab bans .

    ●1983:U {. s} s}}} FDA Muab nws los ntawm Gras (feem ntau lees paub tias muaj kev nyab xeeb) li kev nyab xeeb.

Dosicalical cov txheej txheem:

● Cov neeg laus:300-600 mg Txhua 4-6 teev, tsis yog tshaj 4 g / {.

● Duration:Txwv rau 5-7 hnub kom txo qis kev lom zem lom zem .

Ib nrab-lub neej thiab sijhawm:

● Phenacetin:1-3 teev (luv luv nyob rau cov metabolism sai sai) .

● Acetaminophen:2-4 teev, txuas ntxiv cov kev mob analgesic .

Kev Saib Xyuas Kev Ncaj Ncees:
Tsis zoo li cyclic regimens (e {. g {}}}}} Cov tshuaj lom neeg thiab kev mob siab dua thiab cuam tshuam}

Toxicity toxicity:

● Methemoglobinemia:Tsawg kawg nkaus txoj sia muaj kev phom sij; tshwm sim los ntawm p-phenetidine cuam tshuam nrog hemoglobin .

● Kev sib haum:Pob xoo, bronchospasm .

Ntev phalue:

Forage puas:Tubulasumeditial MANRASITIONS thiab PAPLOSATY NECRIABCE vim Oxidative Metabolite txuam ....

● Carcinogenicity:Nce lub zais zis thiab lub raum plab me ({20+ xyoo ntawm kev siv) .

Kev phom sij tshaj plaws:

Kev siv kev sib xyaw ua ke:APC ntsiav tshuaj ua kom lub raum ua rau mob raum ua kom muaj kev puas tsuaj ntawm cov tshuaj aspirin lub neesxic synero .

Profile ● Tej yam muaj peev xwm:Cyp2e1 enzyme polymorphisms heightened kev sib tw .

PTC AMBRIGUITY:Lo lus "PTC" tsis yog qauv hauv Phenacetin cov ntawv nyeem {}}} kev txhais tau:

● PharmacotherQhov chaw:Analgesic / antipyretic .

Agucation Toxicology:Qhia txog carcinogenicity kev tshawb fawb .

● Kev yuam cai:Muaj peev xwm npaj "pka" (kua qaub cais tawm) lossis "PK / PD" (pharpacodynict) profiling .

Niaj hnub nawj hloov:

Kev Tshawb Fawb:Ua kev pab rau kev nyab xeeb hauv kev nyab xeeb tshuaj, cuam tshuam kev soj ntsuam kev soj ntsuam tom qab kev soj ntsuam kev lag luam {}}

● Derivatives:Acetaminophen, nws cov metabolite muaj kev nyab xeeb, tswj hwm OTC lag luam .

Cov Txheej Txheem Ntau Lawm:

1. nitration:Ethoxybenzene yog nitrated los tsim p-nitrophenetole .

2.} Txo:Catalaltic hydrogenation hloov Nitro rau cov pab pawg amine .

3. acetylation:Cov tshuaj tiv thaiv nrog acetic anhydride yieldride phenacetin .

Txoj Cai Hauv Phailacy Nyob Hauv Pharma:

● Tswjhwm hwm hwm:Nws rho tawm cov sab nrauv ntawm sab nraud (nqus, faib tawm, cov metabolism, ua kom tiav) sim .

● Kev cai tshuaj yeeb siv tshuaj:Coj mus soj ntsuam ntawm ntau-cov khoom xyaw .

Vs . acetaminophen:

Kev Nyab Xeeb:Acetaminophen tsis muaj phenacetin lub carcinogenicity tab sis txaus ntshai hepatotoxicity ntawm high dig .

Atricacy:Cov khoom siv hluav taws xob rau qhov mob / kub taub hau, tab sis phenacetin lub metabolite profile nce kev lom zem .

Vs . nsaids:

● GI / Renal Rensors:Phenacetin spared lub plab tab sis raug mob raum; NSAIDS (e {{. g}}}}}}}}}}, ibuprofen) Rov qab no profile.

● Kev soj ntsuam tom qab kev lag luam:Phenacetin underscored qhov xav tau rau kev saib xyuas kev nyab xeeb mus ntev .

● Carcinogenicity Testing:Tam sim no yuav tsum muaj rau kev siv yeeb tshuaj ntev .

Kev Tshawb Nrhiav Frontiers:

● Cov neeg sawv cev:Tshawb xyuas cov antioxidant kom mitigate analgesic neprochy .

A Hom Phiaj Me Me Me Meolite Xa:Engineering prodrugs uas zam kev lom .

Kev Lag Luam Npe	Clomiphene, Clomifene, Clomid
Cas	62-44-2
Tus hniav loj	179.216
Mf	C10H13no2
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	Dawb crystalline hmoov

 

 

Kev xav tau, thov hu rau peb

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Phenacetin txoj kev sib tw los ntawm hero mus rau villareia qhia txog kev ntsuas tshuaj lom zem thiab kev ntsuas cov kab kev ceev faj, cov lus qhia txog kev tawm tsam thiab kev tawm tsam kev ua kom muaj kev tsim kho hauv qhov mob kho .

Cim npe nrov: Phenacetin rau daws cov mob ua tau: {{}}}}}} {{{}} cov chaw tsim khoom, cov chaw tsim khoom, Hoobkas