Letrozole Breast Cancer Tshuaj CAS:112809-51-5

Cov tshuaj no yog siv los kho qee yam mob qog noj ntshav mis (xws li cov tshuaj hormone-receptor-zoo mob qog noj ntshav mis) hauv cov poj niam tom qab lub cev tsis muaj zog. Letrozole kuj tseem siv los pab tiv thaiv kev mob qog noj ntshav rov qab los. Qee cov qog nqaij hlav hauv lub mis yog tsim kom loj hlob sai los ntawm cov tshuaj hormones ntuj hu ua estrogen. Letrozole txo cov tshuaj estrogen hauv lub cev thiab pab kom qeeb lossis thim rov qab qhov kev loj hlob ntawm cov qog nqaij hlav mis no.

Tamoxifen kuj tseem siv los kho hormonally-responsive mis mob cancer, tab sis nws ua li ntawd los ntawm kev cuam tshuam nrog estrogen receptor. Txawm li cas los xij, letrozole tsuas yog siv tau rau cov poj niam tom qab lub cev tsis muaj zog, uas cov tshuaj estrogen yog tsim nyob rau hauv cov ntaub so ntswg peripheral (xws li hauv cov ntaub so ntswg adipose, zoo li lub mis) thiab ntau qhov chaw hauv lub hlwb. Hauv cov poj niam premenopausal, qhov tseem ceeb ntawm cov tshuaj estrogen yog los ntawm zes qe menyuam tsis yog cov ntaub so ntswg peripheral, thiab letrozole tsis zoo.

Nyob rau hauv BIG 1-98 Txoj Kev Kawm, ntawm cov poj niam tom qab yug me nyuam nrog hormonally-responsive mis mob cancer, letrozole txo qhov rov tshwm sim ntawm qog noj ntshav, tab sis tsis hloov cov ciaj sia taus, piv rau tamoxifen.

 

 

 

Letrozole yog siv los kho mob cancer ntawm lub mis thaum ntxov rau cov poj niam uas tau dhau los lawm (hloov lub neej; kawg ntawm kev coj khaub ncaws txhua hli) thiab cov uas tau muaj lwm yam kev kho mob, xws li hluav taws xob lossis kev phais kom tshem tawm cov qog. Nws kuj yog siv los kho mob cancer ntawm lub mis thaum ntxov rau cov poj niam uas tau dhau los lawm thiab cov uas twb tau kho nrog cov tshuaj hu ua tamoxifen (Nolvadex) tau 5 xyoos. Letrozole kuj tseem siv tau rau cov poj niam uas tau dhau los ua poj niam ua ntej kev kho mob qog noj ntshav mis uas tau kis hauv lub mis lossis mus rau lwm qhov ntawm lub cev lossis hauv cov poj niam uas mob qog noj ntshav mis zuj zus thaum lawv noj tamoxifen. Letrozole yog nyob rau hauv ib chav kawm ntawm cov tshuaj hu ua nonsteroidal aromatase inhibitors. Nws ua haujlwm los ntawm kev txo qis cov tshuaj estrogen uas tsim los ntawm lub cev. Qhov no tuaj yeem ua rau qeeb lossis nres qhov kev loj hlob ntawm qee hom qog nqaij hlav cancer mis uas xav tau tshuaj estrogen kom loj hlob.

Letrozole yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj, tsis yog steroidal, xaiv aromatase inhibitor thiab yog li cov tshuaj tiv thaiv. Nws tiv thaiv aromatase los ntawm kev tsim cov tshuaj estrogens los ntawm kev sib tw, thim rov qab khi rau lub heme ntawm nws cytochrome P450 unit. Qhov kev txiav txim yog qhov tshwj xeeb, thiab letrozole tsis txo cov tshuaj corticosteroids.

 

 

Letrozole los ua ib ntsiav tshuaj los ntawm qhov ncauj ib hnub ib zaug nrog lossis tsis muaj zaub mov. Noj letrozole nyob ib ncig ntawm tib lub sijhawm txhua hnub. Ua raws li cov lus qhia ntawm koj daim ntawv sau tshuaj kom zoo, thiab nug koj tus kws kho mob lossis tus kws muag tshuaj kom piav qhia ib feem uas koj tsis nkag siab. Noj letrozole raws nraim li qhia. Tsis txhob noj ntau lossis tsawg dua lossis noj ntau dua li koj tus kws kho mob tau sau tseg.

Tej zaum koj yuav tau noj letrozole rau ob peb xyoos lossis ntev dua. Txuas ntxiv noj letrozole txawm tias koj xav tias zoo. Tsis txhob noj letrozole yam tsis tau tham nrog koj tus kws kho mob.

Nug koj tus kws muag tshuaj lossis tus kws kho mob kom luam ib daim qauv ntawm cov chaw tsim khoom cov ntaub ntawv rau tus neeg mob.

Cov tshuaj antiestrogen ntawm letrozole tau pom tias muaj txiaj ntsig zoo hauv kev kho ua ntej rau kev txiav cev xeeb tub, ua ke nrog misoprostol. Nws tuaj yeem siv rau qhov chaw ntawm mifepristone, uas yog kim thiab tsis muaj nyob hauv ntau lub tebchaws.

Letrozole qee zaum siv los kho gynecomastia, txawm hais tias nws yog qhov zoo tshaj plaws ntawm qhov no yog tias ntes tau nyob rau theem pib (xws li hauv cov neeg siv cov tshuaj anabolic steroids).

Qee cov kev tshawb fawb tau pom tias letrozole tuaj yeem siv los txhawb cov spermatogenesis hauv cov txiv neej cov neeg mob uas tsis muaj kev cuam tshuam azoospermia.

Letrozole kuj tau siv los kho endometriosis.

Endometrial stromal sarcomas yog hormonally rhiab hlav qog raws li nws yog sawv cev tias letrozole txo cov ntshav estrogen. Letrozole yog qhov ua tau zoo thiab yog qhov kev xaiv zoo rau kev tswj hwm tus kab mob no mus ntev. Tsis tas li ntawd nyob rau hauv kev tshawb fawb ntawm Uterine myoma qhov ntim tau ua tiav zoo los ntawm kev siv cov aromatase inhibitor. Kev pib sai sai ntawm kev nqis tes ua thiab zam qhov pib ntawm gonadotropin flare nrog ib qho aromatase inhibitor.

Letrozole tau raug sau tseg kom muaj kev nyab xeeb thiab muaj txiaj ntsig zoo rau kev txhim kho qhov siab thiab pubertal hauv cov menyuam yaus nyob nrog kev cai lij choj ncua kev loj hlob thiab puberty, thiab zoo dua li testosterone hais txog kev txhim kho hauv cov qe ntshav thiab ncua kev laus ntawm pob txha. Qhov no tau sau tseg hauv kev tshuaj ntsuam meta-tshaj tawm los ntawm Dutta li al. uas txheeb xyuas cov ntaub ntawv los ntawm 7 qhov sib txawv randomized tswj kev sim.

 

 

· Ua ntej noj letrozole,

· Qhia rau koj tus kws kho mob thiab tus kws muag tshuaj yog tias koj ua xua rau letrozole, lwm yam tshuaj, lossis ib qho ntawm cov khoom xyaw hauv cov ntsiav tshuaj letrozole. Nug koj tus kws muag tshuaj kom paub cov npe ntawm cov khoom xyaw.

· Qhia rau koj tus kws kho mob thiab tus kws muag tshuaj seb lwm yam tshuaj thiab cov tshuaj uas tsis yog tshuaj, cov vitamins, tshuaj noj, thiab tshuaj ntsuab uas koj noj lossis npaj yuav noj. Nco ntsoov hais txog ib qho ntawm cov hauv qab no: cov tshuaj uas muaj cov tshuaj estrogen xws li tshuaj hormone hloov kho (HRT) thiab cov tshuaj tiv thaiv hormonal (cov tshuaj tiv thaiv yug menyuam, thaj ua rau thaj, lub nplhaib, thiab txhaj tshuaj); raloxifene (Evista); thiab tamoxifen (Nolvadex).

· Qhia rau koj tus kws kho mob yog tias koj muaj cov roj cholesterol siab, osteoporosis (tus mob uas cov pob txha tawg thiab tawg yooj yim), lossis kab mob siab.

· Koj yuav tsum paub tias letrozole yuav tsum tsuas yog noj los ntawm cov poj niam uas tau dhau los lawm thiab tsis tuaj yeem xeeb tub. Txawm li cas los xij, yog tias koj cev xeeb tub lossis pub niam mis, koj yuav tsum qhia koj tus kws kho mob ua ntej koj pib noj cov tshuaj no. Letrozole tuaj yeem ua mob rau tus menyuam hauv plab.

· Koj yuav tsum paub tias letrozole tuaj yeem ua rau koj tsaug zog. Tsis txhob tsav tsheb lossis siv cov tshuab kom txog thaum koj paub tias cov tshuaj no cuam tshuam rau koj li cas.

 

 

Khoom npe	Femara
CAS	112809-51-5
Molar loj	285.310
Formula	C17H11N5
Purity	Tshaj 98%
Yam khoom	Dawb crystalline hmoov

 

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Letrozole yog cov tshuaj siv feem ntau hauv kev kho mob qog noj ntshav ntawm lub mis hauv cov poj niam postmenopausal. Nws belongs rau ib chav kawm ntawm cov tshuaj hu ua aromatase inhibitors.

Nws lub luag haujlwm tseem ceeb yog txo qis kev tsim cov tshuaj estrogen hauv lub cev. Cov tshuaj estrogen tuaj yeem txhawb kev loj hlob ntawm qee yam mob qog noj ntshav mis uas yog cov tshuaj hormone receptor-zoo. Los ntawm inhibiting enzyme aromatase, uas koom nrog hauv kev tsim cov tshuaj estrogen, letrozole txo qis cov tshuaj estrogen hauv lub cev, yog li ua kom qeeb lossis nres qhov kev loj hlob ntawm cov qog nqaij hlav.

Tsis tas li ntawd, letrozole qee zaum siv cov ntawv sau tawm hauv kev kho mob fertility rau cov poj niam uas tsis muaj ovulation los yog tsis ovulating txhua. Nws tuaj yeem txhawb nqa ovulation los ntawm kev cuam tshuam cov tshuaj estrogen ib ntus, uas tuaj yeem pab ua kom muaj menyuam hauv qee kis.

Raws li nrog rau txhua yam tshuaj, letrozole tuaj yeem muaj kev phiv, suav nrog kub kub, mob pob qij txha lossis mob leeg, qaug zog, tawm hws ntau ntxiv, thiab muaj peev xwm poob pob txha. Nws yog ib qho tseem ceeb rau cov tib neeg noj letrozole los tham txog kev txhawj xeeb lossis kev mob tshwm sim nrog lawv tus kws kho mob.

 

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