Cialis (Tadalafil) Kev Kho Mob Rau ED CAS: 171596-29-5

Tadalafil yog siv los kho cov teeb meem ntawm kev sib deev txiv neej (impotence lossis erectile kawg-ED). Ua ke nrog kev sib deev stimulation, tadalafil ua haujlwm los ntawm kev ua kom cov ntshav ntws mus rau qhov chaw mos los pab tus txiv neej tau txais thiab ua kom erection. Tadalafil kuj tseem siv los kho cov tsos mob ntawm tus mob prostate loj (benign prostatic hyperplasia-BPH). Nws pab txo cov tsos mob ntawm BPH xws li nyuaj thaum pib tso zis, cov kwj deg tsis muaj zog, thiab yuav tsum tso zis ntau zaus lossis ceev ceev (xws li thaum nruab nrab hmo ntuj). Tadalafil tau xav tias ua haujlwm los ntawm kev so cov leeg nqaij hauv prostate thiab zais zis. Cov tshuaj no tsis tiv thaiv kab mob sib deev (xws li HIV, kab mob siab B, gonorrhea, syphilis). Xyaum "kev sib deev nyab xeeb" xws li siv cov hnab looj tes latex.

 

 

 

Tadalafil ua haujlwm los ntawm kev pab txo cov hlab ntsha hauv qhov chaw mos, ua rau cov ntshav ntws yooj yim dua rau hauv qhov chaw mos. Yog tias koj muaj erectile kawg, qhov no tuaj yeem ua rau nws yooj yim dua kom tau txais erection. Yog tias koj muaj BPH, qhov no tuaj yeem txhim kho koj cov tsos mob tso zis.

Tadalafil tsis ua rau erections ntawm nws tus kheej - kev sib deev stimulation tseem xav tau.

Tadalafil tsis yog:

· Kho erectile kawg (ED)

· Ua kom koj lub siab xav deev

· Tiv thaiv los ntawm kev sib deev kis kab mob (STIs)

· Ua kev tiv thaiv kab mob

 

 

Yog tias koj npaj yuav siv tadalafil, koj yuav tsum noj nws li 30 mus rau 60 feeb ua ntej npaj kev sib deev. Ib qho erection yog ua tau mus txog 36 teev tom qab noj nws - txhais tau tias lub peev xwm kom muaj erection yuav kav ntev li no, tab sis qhov tseeb erections yuav kav rau ib lub sij hawm ib txwm.

Nws tseem tuaj yeem noj tau raws li cov tshuaj noj txhua hnub. Koj tus kws kho mob tuaj yeem pom zoo rau cov ntsiav tshuaj txhua hnub yog tias koj muaj erectile kawg thiab xav tias yuav koom nrog kev sib deev ntau dua ob zaug hauv ib lub lis piam. Yog tias koj noj tadalafil rau BPH, koj yuav tsum tau noj tadalafil txhua hnub kom muaj kev txhim kho ntawm koj cov tsos mob tso zis.

Koj yuav tsum tsis txhob noj ntau tshaj ib ntsiav tshuaj tadalafil hauv 24 teev. Koj yuav tsum tsis txhob noj nrog lwm cov tshuaj ED.

 

 

Tadalafil tej zaum yuav tsis muaj kev nyab xeeb rau cov neeg uas muaj qee yam mob, suav nrog cov neeg uas tau mob stroke, muaj kab mob plawv lossis retinitis pigmentosa (mob qhov muag).

Nws tuaj yeem cuam tshuam nrog ntau yam tshuaj, tshwj xeeb tshaj yog nitrates (siv hauv qee hom kab mob plawv) thiab tshuaj ntshav siab. Yog tias koj noj nitrates nyob rau hauv ib daim ntawv, los yog nyob rau hauv kev kho mob pulmonary hypertension, koj yuav tsum tsis txhob noj tadalafil.

Yog tias koj tab tom xav txog kev siv tadalafil thov tham nrog koj tus kws kho mob.

 

 

Hauv cov neeg mob noj qab haus huv, tadalafil raug (AUC) nce koob tshuaj ntau dua li ntawm 2.5 txog 20 mg. Cov ntshav plasma nyob ruaj khov yog ua tiav nyob rau hauv 5 hnub tom qab noj ib zaug ib hnub, thiab qhov tshwm sim yog kwv yees li 1.6-fold ntau dua li tom qab ib koob tshuaj. Txhais tau hais tias tadalafil concentrations ntsuas nyob rau hauv ib tug ywj siab txoj kev tshawb no nyob rau hauv cov txiv neej noj qab haus huv kev kawm tom qab kev tswj hwm ntawm ib koob tshuaj ntawm 20 mg thiab ib zaug thiab ntau npaum li cas txhua hnub ntawm 5 mg.

· Absorb

Tom qab ib koob tshuaj ntawm qhov ncauj, qhov siab tshaj plaws plasma concentration (Cmax) ntawm tadalafil tau ua tiav hauv 30 feeb mus rau 6 teev (qhov nruab nrab, 2 teev). Qhov tseeb bioavailability ntawm tadalafil tom qab tswj qhov ncauj tsis tau txiav txim siab.

Tus nqi thiab qhov nqus ntawm tadalafil tsis cuam tshuam los ntawm cov khoom noj; Yog li ntawd, Cialis tuaj yeem noj nrog zaub mov lossis ib leeg.

· Faib

Qhov nruab nrab pom meej ntim ntawm kev faib tawm tom qab kev tswj hwm qhov ncauj yog kwv yees li 63 L, qhia txog kev faib cov tadalafil rau hauv cov ntaub so ntswg. Ntawm kev kho mob concentration, 94% ntawm tadalafil hauv ntshav yog protein khi.

Tsawg dua 0.0005% ntawm cov koob tshuaj tshwm sim hauv cov phev ntawm cov neeg noj qab haus huv.

· Metabolism

Tadalafil feem ntau metabolized los ntawm CYP3A4 rau nws cov catechol metabolite. Catechol metabolites dhau los ua ntau yam methylation thiab glucuronidation los tsim methylcatechol thiab methylcatechol glucuronidate conjugates, feem. Cov metabolite tseem ceeb yog methylcatechol glucuronide. Methylcatechol concentration tsawg dua 10% ntawm glucuronide concentration.

Cov ntaub ntawv hauv vitro qhia tau hais tias cov metabolite tsis xav tias yuav ua haujlwm pharmacologically ntawm cov ntsiab lus ntawm cov metabolite pom.

· Kev tso tawm

Hauv cov ntsiab lus noj qab haus huv, qhov nruab nrab qhov ncauj tshem tawm ntawm tadalafil yog 2.5 L / hr thiab qhov nruab nrab nruab nrab ntawm lub neej yog 17.5 teev. Tadalafil feem ntau yog tawm los ua cov metabolite, feem ntau hauv cov quav (kwv yees li 61% ntawm cov koob tshuaj) thiab qis dua hauv cov zis (kwv yees li 36% ntawm cov koob tshuaj).

· Geriatrics

Cov txiv neej noj qab haus huv cov neeg laus (65 xyoo lossis tshaj saud) tau txo qhov ncauj tshem tawm ntawm tadalafil, ua rau muaj kev cuam tshuam (AUC) 25% siab dua li cov neeg muaj hnub nyoog 19 txog 45 xyoo, tsis muaj kev cuam tshuam rau Cmax. Tsis tas yuav kho cov koob tshuaj raws li hnub nyoog nkaus xwb. Txawm li cas los xij, cov neeg laus yuav tsum tau txiav txim siab ntau dua rau cov tshuaj [saib Kev Siv Hauv Cov Tib Neeg].

· Mob ntshav qab zib

Hauv cov txiv neej mob ntshav qab zib mellitus, 10 mg koob tshuaj tadalafil ua rau kwv yees li 19% txo qhov kis tau tus mob (AUC) thiab 5% txo qis hauv Cmax piv rau cov neeg noj qab haus huv. Tsis tas yuav hloov tshuaj npaum li cas.

· Cov neeg mob prostatic hyperplasia

Tsis muaj qhov sib txawv ntawm qhov raug (AUC thiab Cmax) tau pom nyob nruab nrab ntawm cov laus (70 mus rau 85 xyoos) thiab cov hluas (tsawg dua lossis sib npaug li 60 xyoo) cov neeg mob uas muaj BPH tom qab ib zaug thiab ntau koob ntawm 20 mg ntawm tadalafil Qhov sib txawv tseem ceeb hauv kev kawm. . Tsis tas yuav hloov tshuaj npaum li cas.

 

 

Khoom npe	Cialis, Cidala, Adcirca
CAS	171596-29-5
Molar loj	389.41
Formula	C22H19N3O4
Purity	Tshaj 98%
Yam khoom	Dawb crystalline hmoov

 

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Cialis (lub npe dav dav: tadalafil) yog tshuaj feem ntau siv los kho erectile kawg (ED) hauv cov txiv neej. Nws yog nyob rau hauv chav kawm ntawm cov tshuaj hu ua phosphodiesterase type 5 (PDE5) inhibitors.

Tadalafil ua haujlwm los ntawm kev ua kom cov ntshav ntws mus rau qhov chaw mos thaum muaj kev sib deev stimulation, uas pab cov txiv neej ua tiav thiab tswj kom muaj erection. Nws ua li no los ntawm kev so cov hlab ntsha hauv qhov chaw mos, tso cov ntshav ntau ntxiv rau hauv cov ntaub so ntswg erectile.

Ib cag ntawm kev kho ED, tadalafil kuj tseem muaj lwm lub npe, Adcirca, uas yog siv los kho cov hlab ntsws ntshav siab (PAH) hauv cov txiv neej thiab poj niam. Nyob rau hauv cov ntaub ntawv no, nws yuav pab tau kom cov hlab ntsha nyob rau hauv lub ntsws, uas tso cai rau cov ntshav ntws yooj yim dua.

Cialis, thaum noj raws li qhov xav tau, tuaj yeem siv tau ntev txog 36 teev, tau txais nws lub npe menyuam yaus "cov tshuaj noj hnub so." Kuj tseem muaj cov koob tshuaj qis dua ntawm tadalafil, hu ua Cialis Txhua Hnub, uas tau noj ib hnub ib zaug los muab cov tshuaj qis dua, tsis tu ncua ntawm cov tshuaj hauv lub cev kom ua haujlwm tau zoo.

Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias Cialis / tadalafil tsuas yog yuav tsum tau ua raws li kev taw qhia ntawm tus kws kho mob thiab yuav tsum tsis txhob siv yam tsis muaj tshuaj. Tsis tas li ntawd, nws tsis pom zoo rau txhua tus thiab tuaj yeem muaj kev cuam tshuam nrog lwm cov tshuaj, yog li nws yog ib qho tseem ceeb los tham txog tej yam mob uas twb muaj lawm lossis cov tshuaj nrog kws kho mob ua ntej siv.

 

Cim npe nrov: Cialis (tadalafil) kev kho mob rau ed cas:171596-29-5, Tuam Tshoj cialis (tadalafil) kev kho mob rau ed cas:171596-29-5 manufacturers, lwm tus neeg, Hoobkas