Stromusc Finasteride (Proscar) 5mg rau Plaub Hau Poob Li Cas: 98319-26-7

Nws yog dab tsi: cov khoom siv molecular

Finasteride yog ib qho hluavtaws 4-azasteroid compound, cais raws li aKev sib tw thiab tshwj xeeb inhibitor ntawm hom II 5 -} reductaseCov. Cov enzyme no, feem ntau yog nyob rau hauv lub nuclei ntawm cov hlwb stromal nyob rau hauv prostosterone (tus thawj tus txiv neej pw ua ke) rau hauv nws cov metabolite ntau dua,Dihydrotestosterone (DHT)Cov. Proscar 5mg yog tsim los txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau hauv lub cev, ua rau muaj kev txo qis thiab cov ntaub so ntswg DHT - feem ntau los ntawm60-70%.

Cov ntsiab lus tseem ceeb: Isozyme tshwj xeeb:Qhov tseem ceeb, cov ntaub ntawv finasteride Nws muaj tsawg heev affinity rau hom kuv isozyme (feem ntau ntawm daim tawv nqaij, thiab lub siab xav txog qhov tsis yog- Xaiv tau inibitors. Qhov tshwj xeeb no yog qhov tseem ceeb no rau nws cov kev siv tshuaj kho.

 

 

1.Tissue -} qhov feem cuam: While reducing systemic DHT, Finasteride's most pronounced effects occur in tissues rich in Type II 5α-reductase. The prostate gland experiences the most significant DHT reduction (>80-90% hauv qee qhov kev ntsuas qhov tseeb), ua rau nws cov teebmeem kev kho mob tseem ceeb. Cov hauv plaub hau plaub hau kuj tseem pom cov taub hau plaub hau kuj txo qis, underpinning nws daim ntawv thov plaub hau (txawm nyob ntawm qhov qis dua).

2.Hormonal kev hloov pauv yam tsis muaj qhov uas:Cov finasteride ua tiav nws cov kev cuam tshuam yam tsis txo qis ntshav testosterone ntau ntau. Qhov tseeb, cov ntawv Testosterone muaj ntau ntxiv nce me ntsis (10-20%) vim txo qis dua rau DHT. Qhov no txiav txim siab nws lub tswv yim los ntawm androgen deprivation deprivation kev kho (zoo li Gnrh agonists, kub nrawm, osteoporosis, kev sib deev, kev sib deev tsis zoo). Finasteride yoganti - and androgenictshwj xeeb rau DHT, tsis davanti - tilesosterone.

3.Slow, nce zuj zus:Cov kev soj ntsuam cov txiaj ntsig ntawm cov yeeb yam prostate thiab cov yeeb yam tso cai tsis yog tam sim. Nws yuav siv sij hawm3-6 hlisTxhawm rau saib xyuas qhov ntsuas kom tsawg hauv qhov loj me me (feem ntau 20-30% dhau lub sijhawm ntev) thiab coj cov tsos mob txhim kho. Cov txiaj ntsig ntau ntawm kev tso zis rau kev tso zis yuav sivTxog li 12 lub hlisCov. Qhov no qhia txog cov txheej txheem qeeb ntawm epithelial cell apoptosis (programm

4.irreversible khi (mechanism -} Raws inactivation):Finasteride tsis yog cia ib ntus thaiv cov enzyme; Nws ua raws li akev tua tus neeg tua tsiajCov. Nws khi cov lus sib dhos rau cov enzyme, sib sau ib qho ruaj khov thiab tas mus li tsis ua rau qhov tshwj xeeb enzyme molecule. Lub cev yuav tsum synthesize tshiab enzyme los ua kom muaj kev ua si txawm tias nws muaj cov nyhuv luv luv ib nrab {2 {2} lub neej. Nov yog ib qho tseem ceeb ntawm cov kws tshuaj portacological nuarance.

5.Ua -} Cov nqaij mos yog:Lub 5mg koob tshuaj ua tiav ze rau -} ua tiav surmation ntawm hom II5 - reductase nyob rau hauv prevetate. Cov koob tshuaj ntau dua muaj tsawg dua DHT kev txhawb nqa ntxiv los yog chaw kuaj mob rau BPP, ua tiav 5MG cov koob tshuaj zoo rau qhov qhia no.

1.Benign prostatic hyperplasia (bpph):Nov yog tusthawj thiab fda - Pom zoo qhia rau prescar 5mg.

○ Me nyuam:Los ntawm drastically txo intraprostatic dHT, cov meteride reverses cov hormonal stimulus tsav prostate glimular thiab stromal cell kev loj hlob. Qhov no ua rau muaj kev txo qis hauv cov kua roj prostate.

Pab nyiaj pab:

Gon Cov tsos mob nyem: Improves lower urinary tract symptoms (LUTS) like weak stream, hesitancy, straining, urgency, frequency, nocturia, and incomplete emptying. Improvement is often more pronounced in men with larger prostates (>40ml).

Txo txo ​​txoj kev pheej hmoo ntawm cov teeb meem:Ho txo ​​qis qis ntev - sij hawm muaj kev pheej hmoo ntawmKev tso zis tso tawm (AUR)tsim nyog cleence thiab qhov xav tauBph {- muaj kev phais mob(zoo li turp). Qhov kev tiv thaiv no yog qhov loj ntev -} cov txiaj ntsig tau txais.

A Kab Mob Kev Kho Mob:Tsis zoo li alpha - blockers (piv txwv li cov tamsulosin) uas tsuas yog muab cov kev pab cuam zoo los ntawm kev so cov leeg du cov leeg, finasterideHloov kho cov txheej txheem hauv qablos ntawm shrinking lub prostate. Qhov no ua rau nws tshwj xeeb tshaj rau ntev - kev tswj hwm lub sijhawm.

2.androgenetic alopecia (txiv neej qauv plaub hau poob) -Tawm -} daim ntawv lo:Thaum lub sij hawm 1mg koob tshuaj (propecia) yog fda-}}}}} Pom zoo rau cov plaub hau hle, covTib Kwv Txheemsiv rau 5mg ntsiav tshuaj. Qee cov kws kho mob tuaj yeem sau ntawv rau premcar 5mg rau kev plaub hau hle, mus qhia cov neeg mob), pom tias nws yog tus nqi-}}}}}}} Xaiv lwm txoj hauv kev rau Propecia. * Qhov no yog ib qho tawm -} daim ntawv thov daim ntawv lo; Kev ua tau zoo yog sib npaug rau 1mg thaum Dosed tsim nyog, tab sis cov ntsiav tshuaj 5

3.Djunct kho mob:Qee lub sij hawm siv nrog alpha {{0} blocker (zoo li TAMSulosin lossis Alfuzosin) hauv {{1} - loj propostates. Qhov kev sib xyaw ua ke no (piv txwv li, jalyn) ob qho tib si zoo li qub (kev nthuav dav) thiab cov leeg nqaij (feem ntau ua cov leeg ua kom zoo dua qub piv rau cov tshuaj ib leeg.

Cov tsos mob siv tau tau zoo:Muab cov ntsiab lus nyem los ntawm cov yeeb yam tso zis rau cov txiv neej uas muaj BPP.

● Postate ntim txo:Ncaj qha chaw nyob lub anatomical ua rau pom kev hauv glandular bph.

● Prophylaxis tawm tsam teeb meem:Cov txiaj ntsig tshaj plaws yog qhovQhov tseem ceeb txo nyob rau hauv kev pheej hmoo ntawm kev pheej hmoo ntawm AUR thiab yav tom ntej bph -}} muaj feem cuam tshuam kev tiv thaiv kev tiv thaiv kev phais mob.Qhov no txhais tau los txhim kho lub neej zoo thiab txo tus nqi kev noj qab haus huv ntev - sij.

● Tsis - urtive:Yuav tsum khaws cov txuj ci Testosterone, zam kev phiv loj ntawm androgen deprivation.

● Kev tswj hwm qhov ncauj:Yooj yim ib zaug - noj mov txhua hnub.

● Ntev ntev- xyoo kev ua tau:Cov txiaj ntsig tau pab txhawb nqa nrog kev siv txuas ntxiv. Kev tshawb fawb pom zoo ua tau kev ua tau zoo nyob rau yam tsawg 4-6 xyoos thiab yuav muaj ntev dua.

Tus nqi {{0- ua tau zoo (rau cov plaub hau hle tawm - daim ntawv lo):Thaum cov ntsiav tshuaj splitting yog qhov tsim nyog thiab ua tau, proscar 5mg muaj cov nqi txuag tau muaj nuj nqis tshaj tawm cov khoom lag luam uas yog 1mg rau kev kho cov plaub hau poob.

● Txuj ci tshuaj rau BPP: 5mg noj ib leeg ib zaug, nrog lossis tsis muaj zaub mov. Kev sib xws rau lub sijhawm tsis tseem ceeb vim yog ntev -} kav enzyme inhibition, tab sis noj nws tib lub sijhawm ider.

● Duration:Kev kho yogNruam thiab Long - sij hawmCov. Cov txiaj ntsig ploj tau nyob rau hauv lub hlis ntawm kev txiav tawm raws li DHT qib nce thiab prostate regrowth tshwm sim.

E. ntsiav tshuaj splitting (tawm {- daim ntawv lo rau plaub hau poob):Yog hais tias sau tseg tawm -} daim ntawv lo rau alopecia, piv txwv li, rau hauv quarters threing ~ 1.25mg tej daim lossis tsib yielding ~ 1mg). Thaum feem ntau ua tau zoo thiab kev coj ua, splitting qhia cov teeb meem muaj peev xwm:

○ Siv cov ntaub ntawv tsis raug:Uneven splitting ua rau tsis sib xws noj txhua hnub.

Yes Stability:Raug rau sab hauv cov tub ntxhais hluas yuav ua rau tsis taus sai dua yog tias khaws cia tsis raug (txawm tias zoo kawg nkaus yog qhov ruaj khov).

Tuav tuav:Yuav tsum tau saib xyuas thiab tshuaj ntsuab zoo. Tsis pom zoo rau cov neeg mob nrog teeb meem dexterity.

Cov kev tswj hwm:Splitting yog kev hloov kho ntawm fda -}} Pom cov khoom lag luam uas pom zoo.

Ultive Daj:Feem ntau tsis xav tau raws li lub hnub nyoog, haiv neeg, lossis me -} xob siab raum / hepatic tsis taus. Txawm li cas los xij, ceev faj yog qhia nyob rau hauv daim siab mob.

Tsis zoo li Anabolic cov tshuaj tsw qab lossis lwm yam tshuaj noj, me ntsistsis ua raws li lub sijhawm "kev voj voog"(Sijhawm ntawm kev siv ua raws li los ntawm kev txuas ntxiv). Nws lub tshuab kev cai nyob rautxhawbKev tsuj ntawm DHT.

● Vim li cas tsis cycling?

○ Cov nyhuv:Cov kev kho mob ntawm prostate loj ua maj mam ntau lub hlis. Txwv tsis pub cuam tshuam cov txheej txheem no.

○ DHT rebound:Thaum txuas ntxiv, DHT qib nce sab nraud sai (rov qab mus rau kev nkag mus rau hauv ~ 14 hnub), thim rov qab los ntawm kev loj hlob ntawm kev loj hlob thiab plaub hau.

Aws ntawm cov txiaj ntsig:Cov tsos mob nyem qhov ploj zuj zus thiab prostate regrowth pib hauv 3-12 lub hlis ntawm kev nres. Cov nyhuv tiv thaiv kev tiv thaiv ARUR / phais yog ploj.

Cov Kws Uas Mob Hluav Taws Kub:Qee tus txiv neej yuav tau muaj kev phom sij ib ntus thaum tso zis ib zaug thaum nres.

○ Kev ua plaub hau:Cov plaub hau poob resumes ntawm lub pre - Kev saib xyuas cov quav (telogen effluvium) raws li Anagen theem kev txhawb nqa los ntawm DHT txo tau raug tshem tawm.Kev kho yog tas mus li rau cov txiaj ntsig txhawb nqa hauv BPP thiab alopecia.

Kev nqus:Zoo nqus tau tom qab kev tswj hwm qhov ncauj (bioavailaby ~ 63%). Cov zaub mov noj kom tsis txhob ua kom haum rau qhov kev tshem tawm tab sis yuav ncua sij hawm kom ncua sij hawm.

● Muab:Heev protein -} khi (~ 90%). Faib faib dav dav, suav nrog rau hauv lub prostate thiab seminal kua. Hla cov ntshav -} bech teeb meem me me.

● Metabolism:Cov metabolized ntau ntxiv hauv lub siab feem ntawm CYP3A4 enzyme. Cov ntaub ntawv ob qho loj metabolites (hydroxyfineasteride thiab carboxylic acid derivative), uas yog cov tsis tshua muaj hwj chim inhibitors.

● Tshem tawm ib nrab - lub neej:TusPlasma tshem tawm ib nrab - lub neej yog kwv yees li 6-8 teev nyob rau hauv cov txiv neej hnub nyoog 18-60, txuas ntxiv me ntsis txog 8 teev nyob rau hauv tus txiv neej tshaj 70. Qhov no tsis tshua muaj luv luv {2} muaj lub neej kom meej ntawm cov hlab ntshav.

● Ib nrab - lub neej disconnect & ntev ntawm kev txiav txim:Txawm hais tias nws luv ntshav ib nrab ib nrab - lub neej, finasteride'sTsev kho mob(DHT kev hloov kho) kav ntev dua - kwv yees li24 teev tom qab ib koob tshuaj thiab ruaj khov nrog kev noj tshuaj txhua hnubCov. Qhov pom tseeb paradox tau daws los ntawm nws qhov tshwj xeeb mechanism:

○ Txwv tsis pub:Tus yuam sij yog nws mechanism - Raws inactivation. Thaum nws khi thiab inactivates ib hom II5 -} reductase molecue, uas enzyme yog tas mus li. Cov nyhuv cuam tshuam kom txog thaum lub cev synthesizes lwg tshiab, cov txheej txheem uas siv sijhawm.

Fool Enrinyme Turnerover:The turnover rate (synthesis and degradation) of the Type II 5 -reductase enzyme in target tissues like the prostate is relatively slow. Yog li ntawd, txawm tias cov tshuaj yog tshem tawm los ntawm cov ntshav, qhov inhibited enzyme molecules nyob tsis ua hauj lwm. Kev Dosing Txhua Hnub Ua kom muaj kev haus dej tsis tu ncua los ntawm cov tshuaj uas tseem niaj hnub ua rau cov molecules tshiab, kev tswj hwm kev tswj hwm.

● Excretion:Kwv yees li 39% ntawm cov koob tshuaj yog tawm hauv cov zis (feem ntau yog metabolites,<10% unchanged) and 57% in feces.

Aga Saib xyuas:Finasteride Ntseeg qis qis qis qis psa qib los ntawm kwv yees li50%Tom qab 6-12 lub hlis ntawm kev siv. Qhov no tseem ceeb heev rau kev kuaj mob qog nqaij hlav prostate:

○ Ib qho baseline psa yuav tsum ntsuasua ntejPib kho lossis tom qab 6 lub hlis ntawm kev kho (ib zaug psa psa muaj stabilized).

○ Ib PSA tus nqi thaum nyob rau finasteride yuav tsumsib npaugRau kev sib piv nrog ib txwm muaj nyob rau hauv kev tswj hwm cancer kuaj pom. Muaj kev sawv hauv PSA thaum ntawm Featside kev tawm tsam urological.

● Sab kev cuam tshuam Profile:Qhov kev sib tham tshaj plaws yog kev sib deev nrog kev sib deev (txo qis libido, erectile kawg, txo cov ejaculate ntim), tshwm sim hauv cov neeg tsawg (feem ntau<5-10% in large trials, perception varies). They usually develop early in treatment, and many resolve with continued use or discontinuation. Rarely, persistent sexual dysfunction has been reported. Gynecomastia can occur. Mood changes are debated but reported anecdotally. Consider the risk-benefit profile carefully.

Teratogenicity:Finasteride qeb X. Nws tuaj yeem ua rau muaj kev tsis ncaj ncees hauv tus txiv neej hauv plab ntawm tus poj niam cev xeeb tub yog tias tus poj niam cev xeeb tub yog tias muaj cov ntsiav tshuaj uas cev xeeb tub yog tawg. Cov poj niam uas yog lossis tej zaum yuav xeeb tub yuav tsum tsis txhob muab cov ntsiav tshuaj tawg / tawg. Los ntawm cov ntsiav tshuaj ua rau tsawg kev pheej hmoo dhau los ntawm kev sib chwv qhuav, tab sis ceev faj yog qhia.

● Oset thiab Aunrea:Thaum kho cov txiaj ntsig yuav siv sijhawm siv lub hlis los ua kom pom, tusCov nyhuv biochemical(DHT kev hloov kho) pib hauv cov sij hawm ntawm thawj zaug thiab muaj kev cuam tshuam rau kev siv hluav taws xob tsis txaus ntseeg txawm tias lub luv ntshav ib nrab {{1} lub neej.

Hom	Tus hma
Kev Lag Luam Npe	Proscar, Propecia, Damocare, Finpecia, finide, Fincar, Finax, Hais Lus, Finasteride
Cas	98319-26-7
Tus hniav loj	372.549
Cov lus ntawm ib txoj kab ke	C23H36N2O2
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	5Mg * 100

 

 

Kev xav tau, thov hu rau peb

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Finasteride 5mg (proscar) tsis yog ib qho tshuaj xwb; Nws yog qhov cuab yeej precision manipulating ib qho kev ntseeg biochemical tshwj xeeb. Nws tus nqi nyob hauv nws lub peev xwm los xaiv cov neeg muaj DHT, yog li rov qab thiab tiv thaiv cov androgen {2} Cia kev loj hlob ntawm prostate. Nws cov txiaj ntsig hauv kev txo cov tsos mob bph thiab, tiv thaiv kev mob hnyav xws li tso zis thiab phais mob yog zoo- tsim. Cov pom zoo sib cav ntawm nws cov ntshav luv ib nrab - lub neej thiab ntev} Kev kuaj mob thiab ntev} Kev Txom Nyem Tsis Txaus Ntseeg ntawm nws lub hom phiaj enzyme. Nkag siab cov inricacies - qhov tshwj xeeb, cov kws kho hniav qeeb, yog qhov tseem ceeb rau kev kho kom txuas ntxiv - yog qhov kev nyab xeeb rau nws txoj kev nyab xeeb thiab siv tau zoo. Nws ua piv txwv li cas kev nkag siab tob tob txhais ua kev kho mob hauv tsev kho mob rau cov neeg laus.

Cim npe nrov: Stromusc Finasteride (Proscar) 5mg Rau Cov Plaub Hau Poob CAS: 98319-26, Tuam Tshoj Sawm Qiv: 98319-26-7 Manufacturers, Chaw muag khoom, Hoobkas