Siab -Quality STROMUSC Oxymetholone (Anadrol) 50mg Rau Lub Cev Muaj Zog CAS: 434-07-1
Oxymetholone, ua lag luam nyob rau hauv lub npe lag luam Anadrol ntawm lwm tus, sawv cev rau ib qho ntawm qhov muaj zog tshaj plaws ntawm qhov ncauj anabolic -androgenic steroids (AAS) puas tau tsim los rau tib neeg kev siv tshuaj kho mob. Thawj tsim nyob rau hauv 1959 los ntawm Syntex Pharmaceuticals, qhov no dihydrotestosterone (DHT) derivative yog thawj zaug engineered los kho anemia thiab nqaij - nkim tej yam kev mob.
Oxymetholone: Ib Daim Ntawv Qhia Tshuaj thiab Tshuaj Kho Mob
Oxymetholone, ua lag luam nyob rau hauv lub npe lag luam Anadrol ntawm lwm tus, sawv cev rau ib qho ntawm qhov muaj zog tshaj plaws ntawm qhov ncauj anabolic -androgenic steroids (AAS) puas tau tsim los rau tib neeg kev siv tshuaj kho mob. Thawj tsim nyob rau hauv 1959 los ntawm Syntex Pharmaceuticals, qhov no dihydrotestosterone (DHT) derivative yog thawj zaug engineered los kho anemia thiab nqaij - nkim tej yam kev mob. Nws cov qauv tshuaj muaj cov 2-hydroxymethylene pawg txuas nrog DHT qaum, kev hloov kho uas hloov pauv nws cov androgenic profile thaum ua kom nws cov peev xwm anabolic. Kev nkag siab txog qhov sib xyaw no yuav tsum tau txav mus dhau ntawm cov neeg ua si hauv gym thiab tshuaj xyuas nws cov khoom siv tshuaj raug cai, kev siv tshuaj kho mob, thiab kev siv lub cev.
Chemical Characteristics thiab Pharmacological Identity
Chemically tsim los ua 17 -hydroxy-2-(hydroxymethylene)-17-methyl-5 -androstan-3-one, oxymetholone belongs rau 17 -alkylated steroid tsev neeg. Qhov no alkylation ntawm 17th carbon txoj hauj lwm ua rau cov molecule kom muaj sia nyob ua ntej-dhau ntawm lub siab metabolism thaum tswj qhov ncauj, tso cai rau nws bioavailability uas tsis hloov pauv testosterone tsis muaj. Txawm li cas los xij, qhov zoo ntawm cov qauv no los nrog cov kev txhawj xeeb ntawm hepatotoxicity uas txawv nws los ntawm kev txhaj tshuaj testosterone esters. Cov khoom sib xyaw ua pov thawj muaj kev sib koom ua ke siab rau androgen receptors thaum tseem ua kom pom kev ua haujlwm progestogenic tseem ceeb-ib yam tsis tshua muaj tus yam ntxwv ntawm DHT derivatives, uas feem ntau tawm tsam aromatization. Qhov no dual mechanism ntawm kev txiav txim tsim ib tug complex hormonal cascade uas extends tshaj li yooj yim testosterone receptor activation.
Lub molecular architecture ntawm oxymetholone ua rau nws resistant rau aromatase hloov dua siab tshiab, tsis tau nws tseem ua estrogenic cuam tshuam los ntawm ncaj qha stimulation ntawm estrogen receptors thiab muaj peev xwm cuam tshuam nrog progesterone txoj kev. Qhov tshwj xeeb pharmacological tus ntiv tes no cais nws los ntawm testosterone- muab cov khoom sib txuas thiab tsim nyog rau kev txiav txim siab tshwj xeeb thaum muab tshuaj kho.
Kev Siv Tshuaj Kho Mob thiab Cov Lus Qhia Kho Mob
US Food and Drug Administration thawj zaug pom zoo oxymetholone rau kev kho mob hypoplastic anemias los ntawm cov pob txha tsis ua hauj lwm, suav nrog aplastic anemia thiab myelofibrosis. Hauv cov ntsiab lus no, cov tshuaj txhawb nqa erythropoietin ntau lawm thiab txhim kho cov ntshav liab synthesis los ntawm kev txhawb nqa lub raum tso tawm ntawm erythropoietic yam. Cov neeg mob Fanconi anemia thiab lwm yam kab mob hauv pob txha tau txais txiaj ntsig los ntawm kev ua tib zoo saib xyuas kev kho oxymetholone thaum xyoo 1960 thiab 1970s.
Tshaj li kev siv hematological, cov kws kho mob tau sau tshuaj oxymetholone rau HIV-sociated wasting syndrome, mob hnyav rov qab los, thiab cachexia uas tshwm sim los ntawm kev kis kab mob ntev lossis mob qog noj ntshav. Qhov sib xyaw ua ke muaj peev xwm txhawb nqa nitrogen khaws cia thiab cov protein synthesis ua rau nws muaj txiaj ntsig zoo rau kev khaws cov ntaub so ntswg hauv cov neeg mob catabolic. Hauv cov tshuaj kho menyuam yaus, nws kho cov kab mob angioedema thiab txhawb kev loj hlob ntawm cov menyuam yaus prepubertal nrog kev loj hlob hormone tsis txaus, txawm tias cov ntawv thov no yuav tsum tau ceev faj heev txog kev kaw ntxov ntxov epiphyseal.
Kev siv tshuaj kho mob niaj hnub no tau nqaim ntau heev vim yog kev txhim kho ntawm erythropoietin recombinant thiab muaj kev nyab xeeb dua anabolic. Niaj hnub no, cov ntawv tshuaj raug cai tseem muaj tsawg heev thiab feem ntau txwv rau cov xwm txheej tshwj xeeb uas cov kev kho mob ua pov thawj tsis muaj txiaj ntsig.
Physiological Mechanisms thiab Anabolic Properties
Oxymetholone exerts nws cov teebmeem los ntawm ntau txoj kev sib tshuam. Qhov tseem ceeb ntawm cov no yog txhim kho cov protein synthesis hauv cov leeg pob txha. Los ntawm activating androgen receptor signaling cascades, lub compound upregulates ribosomal RNA ntau lawm thiab tsub kom cov kev txhais lus efficiency ntawm nqaij -cov proteins tshwj xeeb. Nyob rau tib lub sijhawm, nws txhim kho qhov sib npaug ntawm nitrogen ntau heev- tsim kom muaj cov nitrogen zoo khaws cia tseem ceeb rau kev tsim cov ntaub so ntswg.
Cov tshuaj steroid kuj cuam tshuam rau myostatin qhia, uas muaj peev xwm txo qis qhov kev tswj tsis zoo ntawm cov leeg nqaij. Tsis tas li ntawd, oxymetholone nce qab los noj mov los ntawm cov txheej txheem cuam tshuam nrog kev hloov kho hypothalamic neuropeptide, tsis ncaj qha txhawb nqa cov calories ntau ntxiv uas tsim nyog rau kev kho cov ntaub so ntswg thiab kev loj hlob. Nws cov teebmeem ntawm erythropoiesis ntev tshaj li pob txha stimulation; Txhim kho cov qe ntshav liab txhim kho cov pa oxygen- nqa lub peev xwm, muaj txiaj ntsig zoo rau cov ntaub so ntswg oxygenation thaum rov qab los ntawm kev raug mob lossis kev phais.
Kev tuav dej sawv cev rau lwm tus yam ntxwv ntawm cov tshuaj, uas yog vim muaj cov tshuaj estrogenic thiab progestogenic. Thaum kho qhov no yuav ua rau muaj kev tswj ntshav siab, hauv cov ntsiab lus kho mob uas muaj kev noj zaub mov tsis zoo, qhov cuam tshuam ntawm cov kua dej ntxiv ntxiv tuaj yeem pab txhawb cov hlab ntshav thaum lub sijhawm noj zaub mov zoo.
Clinical Dosage Parameters thiab Administration Protocols
Kev siv tshuaj kho mob ntawm oxymetholone keeb kwm muaj li ntawm 1 mus rau 5 milligrams ib kilogram ntawm lub cev qhov hnyav txhua hnub rau cov menyuam yaus uas muaj ntshav qab zib, thaum cov neeg laus cov txheej txheem feem ntau muab 1-2 mg / kg / hnub. Rau tus qauv 50mg ntsiav tshuaj formulation, qhov no txhais rau ib ntsiav tshuaj ib hnub twg rau ib tug neeg mob 50kg, tab sis ib tug neeg teb variation yuav tsum tau ceev faj titration. Lub sijhawm kho mob tsis tshua muaj tshaj li peb mus rau rau lub hlis vim muaj kev txhawj xeeb ntawm hepatotoxicity thiab kev pheej hmoo ntawm virilization hauv cov poj niam cov neeg mob.
Cov kws kho mob tau muab cov tshuaj hauv cov tshuaj sib faib lossis ua ib koob tshuaj thaum sawv ntxov, lees paub tias nws qhov luv luv pharmacokinetic profile xav tau cov qib plasma zoo ib yam rau kev kho mob. Cov neeg mob uas muaj mob hepatic impaired contraindicated siv, thaum cov neeg uas muaj kev pheej hmoo ntawm cov hlab plawv yuav tsum tau soj ntsuam nruj heev vim hais tias cov compound cov teebmeem ntawm lipid profiles thiab kua dej tshuav nyiaj li cas.
Pharmacokinetics thiab tshem tawm Ib nrab-Lub neej
Oxymetholone qhia txog ib nrab ntawm cov roj ntsha ib nrab- lub neej ntawm kwv yees li 8 mus rau 9 teev, txawm hais tias qee cov ntawv sau tshuaj hais txog thaj tsam li 5 txog 16 teev nyob ntawm tus neeg lub siab ua haujlwm thiab tus nqi metabolic. Qhov kev tshem tawm luv luv no xav tau kev tswj hwm txhua hnub kom tswj tau qhov kev kho mob ntau. Hepatic metabolism tshwm sim feem ntau los ntawm kev txo qis, hydroxylation, thiab conjugation txoj hauv kev, nrog cov metabolites tawm hauv lub raum.
Lub 17 -alkylated qauv tsim ntsuas ntsuas ntawm lub siab enzyme systems, elevating cov cim xws li ntshav glutamic -pyruvic transaminase (SGPT) thiab alkaline phosphatase. Tsis zoo li cov tshuaj tiv thaiv testosterone uas dhau los ntawm kev ua haujlwm ntawm lub siab ua haujlwm, qhov ncauj tswj hwm tag nrho cov koob tshuaj rau tus kab mob siab ua ntej - dhau los, tsom mus rau lub nra hnyav ntawm daim siab cov ntaub so ntswg.
Treatment Cessation and Recovery Protocols
Kev txiav tawm ntawm kev kho oxymetholone yuav tsum tau saib xyuas kev kho mob. Lub exogenous androgen suppresses hypothalamic{1}}pituitary-gonadal axis muaj nuj nqi, txo cov endogenous luteinizing hormone (LH) thiab follicle- stimulating hormone (FSH) secretion los ntawm kev tawm tswv yim tsis zoo. Hauv cov txiv neej cov neeg mob, qhov kev tawm tsam no tuaj yeem ua rau cov qog nqaij hlav atrophy thiab txo cov spermatogenesis.
Tom qab kev tso tseg, cov kws kho mob tuaj yeem siv cov txheej txheem rov qab uas cuam tshuam nrog tib neeg chorionic gonadotropin (hCG) lossis xaiv cov tshuaj estrogen receptor modulators (SERMs) xws li clomiphene citrate los txhawb kev ua haujlwm ntawm pituitary thiab rov ua cov tshuaj testosterone ntau lawm. Lub sijhawm ntawm kev rov ua kom rov qab muaj zog sib txawv raws li qhov ntev ntawm kev kho mob, ntau npaum li cas, thiab tus neeg endocrine resilience. Cov neeg mob menyuam yaus xav tau kev ceev faj tshwj xeeb txog kev loj hlob ntawm cov phaj loj thiab cov teebmeem hormonal rebound.
Cov ntaub ntawv kho mob
|
Hom |
STROMUSC |
|
Cov npe lag luam |
Anadrol, Anapolon, CI-406, NSC-26198, Oxymetholone |
|
CAS |
434-07-1 |
|
Molar loj |
332.484 |
|
Formula |
C21H32O3 |
|
Purity |
Tshaj 98% |
|
Yam khoom |
50 mg x 100 |
Txhua yam kev xav tau, thov hu rau peb
Email: Jasonraws106@gmail.com
WhatsApp: +86-15572565525
Telegram: +86-15871669785
Xaus
Oxymetholone stands raws li ib tug pharmacologically fascinating tab sis clinically obsolete compound. Nws lub zog zoo kawg nkaus hauv kev txhawb nqa erythropoiesis thiab cov protein synthesis ib zaug ua rau nws muaj txiaj ntsig zoo rau kev kho lub neej - hem cov kab mob ntshav qab zib thiab cov kab mob catabolic.
Cim npe nrov: siab -zoo stromusc oxymetholone (anadrol) 50mg rau bodybuilding cas: 434-07-1, Tuam Tshoj zoo stromusc oxymetholone (anadrol) 50mg rau bodybuilding cas: 434-07-1 manufacturers, lwm tus neeg, Hoobkas
