High-Quality STROMUSC 17a-Methyl-1-testosterone(M1T)10mg Rau Cev cev nqaij daim tawv CAS: 65-04-3

Chemical Architecture thiab Structural Distinctions

17 -Methyl-1-testosterone, abbreviated thoob plaws hauv cov ntaub ntawv tshuaj lom neeg hauv av li M1T, sawv cev rau ob qho kev hloov kho hluavtaws analogue ntawm endogenous testosterone. Cov qauv niam txiv tau dhau los ua ob qhov kev hloov pauv tseem ceeb uas tsim kho nws tus cwj pwm pharmacological. Ua ntej, kev teeb tsa ntawm pawg methyl ntawm kaum xya alpha carbon txoj hauj lwm hloov cov molecule mus rau hauv ib qho 17 -alkylated compound, ib qho kev hloov kho tshwj xeeb uas tau tsim los kom muaj sia nyob hauv lub siab ua ntej-dhau metabolism thiab yog li ua tiav cov ntsiab lus tseem ceeb hauv qab kev tswj hwm qhov ncauj. Yog tsis muaj qhov hloov pauv no, qhov ncauj testosterone feem ntau succumbs rau enzymatic degradation hauv daim siab ua ntej mus txog cov ntaub so ntswg peripheral. Qhov thib ob, qhov kev hloov pauv ntawm ob daim ntawv cog lus los ntawm C4-5 txoj hauj lwm mus rau C1-2 ua rau 1-testosterone caj qaum, cov qauv nuance uas hloov kho cov steroid txoj kev sib raug zoo rau cov androgen receptor thiab muaj peev xwm hloov nws qhov cuam tshuam rau aromatase-mediated conversion.

Cov kev hloov kho tam sim no ua rau muaj qhov sib xyaw nrog qhov sib txawv ntawm kev kho mob sib txawv piv rau kev npaj tshuaj testosterone. Lub qhov ncauj bioavailability conferred los ntawm 17 -methylation los ntawm tus nqi ncaj qha metabolic: lub siab yuav tsum ua cov qauv molecular resistant, tsim oxidative kev nyuaj siab thiab cuam tshuam nrog kev ua haujlwm hepatocellular. Lub caij no, C1-2 ob daim ntawv cog lus theoretically steers lub compound mus rau ib tug ntau txaus nyiam anabolic-rau-androgenic piv tshaj nws niam txiv cov tshuaj hormones, txawm hais tias quantifying qhov piv txwv no nyob rau hauv tib neeg tseem speculative muab qhov tsis muaj kev soj ntsuam soj ntsuam.

M1T qhov tshwm sim sib txawv heev los ntawm txoj kev loj hlob ntawm cov pa anabolic steroids. Feem ntau cov androgens tau teem caij taug qab lawv lub hauv paus pib mus rau nruab nrab -twentieth-cov kev tshawb fawb tshuaj hauv ib puas xyoo uas tsom mus rau cov leeg nqaij-nkim kab mob, anemia, lossis hypogonadism. M1T, los ntawm qhov sib txawv, tau tsim tawm thaum ntxov 2000s los ntawm kev tswj hwm qhov tsis txaus ntseeg los ntawm cov tuam txhab ntxiv ua haujlwm hauv kev lag luam khoom noj khoom haus. Lub sijhawm no, cov khoom sib xyaw ua ke muaj feem cuam tshuam nrog kev tswj hwm anabolic steroids tab sis tsis tau teev meej meej hauv tsoomfwv txoj cai lij choj tau tshwm sim nyob rau hauv dhau -- cov khoom lag luam muag nrog cov lus euphemistic qhia txog kev kho tshuaj hormonal lossis kev ua haujlwm prohormonal.

Lub koom haum nyob hauv qhov kev cai lij choj no tsuas yog ib lub qhov rai luv xwb. Txoj cai evolution nyob rau hauv lub tebchaws United States culminated nyob rau hauv tus Designer Anabolic Steroid Control Act ntawm 2014, uas tau nthuav dav lub ntsiab lus ntawm kev tswj anabolic steroids kom muaj cov tshuaj chemically thiab pharmacologically muaj feem xyuam rau cov tebchaw. Txoj cai nthuav dav no tshem tawm qhov tsis meej pem uas tau tso cai rau M1T txoj kev lag luam xa tawm, rov faib nws nrog cov tshuaj anabolic steroids raws li Schedule III tswj cov khoom raws li Txoj Cai Tswj Cov Khoom. Parallel kev tswj hwm ua raws li thoob ntiaj teb; Lub tebchaws United Kingdom Txoj Cai Kev Siv Tshuaj Tsis raug cai, Canada Txoj Cai Tswj Tshuaj thiab Tshuaj, thiab Australia's Poisons Standard tag nrho tom qab categorized M1T raws li cov tshuaj txwv tsis pub, uas qhia txog kev sib koom ua ke ntawm nws txoj kev tsim txom thiab kev phom sij rau kev noj qab haus huv.

Ntawm qib cellular, M1T ua haujlwm los ntawm canonical androgen receptor signaling txoj kev qhia los ntawm tag nrho cov steroidal androgens. Tom qab kev tswj hwm qhov ncauj thiab kev nqus dej hauv lub cev, cov khoom sib txuas tau nthuav tawm thoob plaws plasma daim nyias nyias mus rau hauv lub hom phiaj hlwb, qhov uas nws khi rau ligand-binding domain ntawm intracellular androgen receptor. Qhov kev sib khi no ua rau muaj kev sib cais ntawm cov proteins uas muaj cua sov, receptor phosphorylation, thiab kev hloov pauv nuclear ntawm cov tshuaj hormone- receptor complex. Nyob rau hauv lub nucleus, lub complex dimerizes thiab interacts nrog tej DNA sequences hu ua androgen teb cov ntsiab lus, modulating transcription ntawm noob tswj myogenesis, erythropoiesis, pob txha ceev, thiab nitrogen retention.

Lub pharmacodynamic sib txawv ntawm M1T thiab testosterone lies tsis nyob rau hauv lub hauv paus kev taw qhia mechanism tab sis nyob rau hauv lub efficiency thiab loj ntawm receptor activation, ua ke nrog metabolic txoj hmoo. Cov txheej txheem rigidity imparted los ntawm C1-2 ob daim ntawv cog lus yuav txhim khu kev ruaj ntseg receptor los yog hloov coactivator recruitment qauv, muaj peev xwm amplifying transcriptional teb ntawm sib npaug receptor nyob qib. Txawm li cas los xij, 17 - pab pawg methyl ib txhij hloov cov txheej txheem metabolic kom deb ntawm txoj hauv kev zoo, yuam kev hepatic biotransformation los ntawm txoj hauv kev uas ua rau muaj kev cuam tshuam nruab nrab thiab oxidative lub nra.

Pharmacokinetic profile ntawm M1T qhia txog kev cuam tshuam hauv qhov ncauj ntawm androgen. Thaum 17 -alkylation tau ua tiav dhau los ua qhov kev puas tsuaj ua ntej, nws tsim qhov sib xyaw nrog kev tshem tawm sai heev uas yuav tsum muaj kev tswj hwm nruj heev los tswj kev kho mob - lossis tsis yog - kho mob cov ntsiab lus, xav tau - plasma concentrations. Cov kev tshawb fawb tshuaj pharmacokinetic tsim kom muaj ib nrab- lub neej qhov tseem ceeb hauv tib neeg cov ntsiab lus tseem tsis muaj los ntawm cov phooj ywg- cov ntaub ntawv tshuaj xyuas, qhov khoob uas tshwm sim los ntawm qhov tsis muaj kev tsim kho tshuaj thiab kev coj ncaj ncees rau kev tswj xyuas kev kawm.

Anecdotal analytical data and user-documented blood concentrations qauv qhia ib tug tshem tawm ib nrab-lub neej nyob nruab nrab ntawm tsib mus rau kaum teev, txawm muaj ntau yam inter-ib tug neeg txawv txav yuav tshwm sim raws li nyob rau hauv hepatic enzyme polymorphisms, concurrent tshuaj siv, thiab zaub mov noj. Qhov no luv luv ib nrab-lub neej sib piv nrog ntev dua - ua yeeb yam testosterone esters xws li enanthate los yog cypionate, uas muaj ib nrab -lub neej ntsuas nyob rau hauv hnub thiab tso cai rau cov sij hawm txhaj tshuaj txhua lub lim tiam lossis ob lub lis piam. Lub pharmacokinetic kev muaj tiag ntawm M1T yog li xav tau ntau koob tshuaj txhua hnub kom ua tiav cov tshuaj hormonal tsis tu ncua, tsim kom muaj lub siab tshaj plaws thiab cov troughs uas tuaj yeem ua rau lub siab tsis ruaj khov thiab lub cev muaj zog piv rau kev xa khoom ruaj khov.

Tshaj li kev pheej hmoo tshuaj tshuaj muaj nyob rau hauv nws tus kheej, M1T cov neeg siv khoom ntsib teeb meem tshwm sim los ntawm kev tsim khoom tsis raug cai. Cov khoom sib xyaw tsis muaj cov tshuaj tsim tshuaj, tsis muaj qhov zoo -tswj cov chaw tsim khoom, thiab tsis muaj kev sim batch rau purity lossis potency. Clandestine lub chaw soj nstuam ua haujlwm yam tsis muaj cov qauv kev tsim khoom zoo tsim cov tshuaj ntsiav, ntsiav tshuaj, lossis cov hmoov nyoos ntawm wildly variable concentration, nquag kis nrog hnyav hlau, microbial pathogens, los yog tag nrho cov tshuaj pharmacological sib txawv tshaj li tshaj tawm. Qhov kev ntsuam xyuas tsis meej no txhais tau hais tias cov neeg siv tsis tuaj yeem tsim kom muaj kev sib raug zoo ntawm kev noj tshuaj los yog kwv yees cov lus teb ntawm lub cev, hloov pauv qhov kev pheej hmoo ntawm cov tshuaj siv tshuaj mus rau hauv kev twv txiaj kev noj qab haus huv stochastic.

Kev txiav txim siab ntawm M1T kev tswj hwm pib qhov kev hloov pauv thiab tsis paub txog qhov rov ua tau zoo thaum lub sijhawm hypothalamic{1}}pituitary-gonadal axis sim ua kom rov ua haujlwm sai. Qee cov tib neeg rov ua cov txheej txheem testosterone ntau lawm nyob rau hauv lub lis piam, thaum lwm tus neeg muaj kev cuam tshuam rau theem nrab hypogonadism xav tau ntau lub hlis ntawm kev cuam tshuam kev kho mob lossis kev kho tshuaj tsis tu ncua. Cov xwm txheej tswj hwm txoj kev rov qab los muaj xws li lub sijhawm ntawm qhov kis tau, cov koob tshuaj ntau ntxiv, tus neeg txiav txim caj ces ntawm hypothalamic rhiab heev, hnub nyoog, thiab lub hauv paus ntawm gonadal muaj nuj nqi.

Kev tswj xyuas kev kho mob ntawm steroid-induced hypogonadism cuam tshuam nrog kev soj ntsuam ntawm cov ntshav testosterone, luteinizing hormone, follicle-stimulating hormone, thiab hematocrit, ua ke nrog cov kev cuam tshuam ntawm tus kheej xws li kev soj ntsuam mus rau cov tshuaj stimulation raws tu qauv. Cov kev xav nrov tshaj plaws uas dhau -- cov khoom txee ntxiv lossis cov txheej txheem PCT nruj nruj tau lees paub tag nrho cov kev kho endocrine tsis sib haum xeeb hauv kev kho mob tiag tiag thiab kev hloov pauv lom neeg.

Hom	STROMUSC
Cov npe lag luam	Methyl-1-testosterone, M1T; SC-11195; Methyldihydroboldenone; 17 -Methyl-1-testosterone; 17 -Methyl-4, 5 -dihydro-δ1-testosterone; 17 -Methyl-δ1-DHT;
CAS	65-04-3
Molar loj	302.458
Formula	C20H30O2
Purity	Tshaj 98%
Yam khoom	10 mg x 100

 

 

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17 -Methyl-1-testosterone encapsulates qhov txaus ntshai ntawm unregulated pharmacological innovation. Yug los tsis yog los ntawm kev tsim kho raug cai tab sis los ntawm kev siv cov kev tswj hwm qhov tsis sib xws, qhov sib xyaw ua ke muab cov haujlwm muaj zog androgenic ntim nrog hnyav hepatotoxicity, lub luag haujlwm ntawm lub plawv, thiab kev cuam tshuam endocrine. Nws txoj hauv kev los ntawm kev ntxiv aisle novelty rau Schedule III tswj cov khoom tsom iav hauv zej zog txoj kev lees paub tias kev hloov kho cov qauv rau steroid scaffolds tsis cuam tshuam txog kev lom zem. Rau cov tib neeg xav txog qhov raug rau qhov sib xyaw no, cov tshuaj muaj tseeb yog qhov tsis txaus ntseeg: tsis muaj cov ntaub ntawv kho mob tsim los txhawb nws txoj kev siv, tsis muaj cov khoom siv tswj xyuas kom zoo, thiab tsis muaj cov txheej txheem txhim khu kev qha tau lav kev rov ua haujlwm ntawm lub cev ua ntej raug mob. Lub architecture ntawm M1T ua rau nws lub ntsiab lus txhais tsawg dua los ntawm nws cov peev xwm anabolic dua li qhov dav thiab qhov hnyav ntawm nws cov teebmeem.

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