Testosterone Undecatate CAS: 5949-44-0

Testosterone undecanoate (TU) muab testosterone (T) hloov pauv rau cov txiv neej hypogonadal thaum noj qhov ncauj tab sis yuav tsum tau ntau koob tshuaj ib hnub twg thiab tsim cov ntshav ntau sib txawv T qib. Peb tau tshawb xyuas cov tshuaj pharmacokinetics ntawm ib qho kev npaj TU tshiab uas tau tswj hwm los ntawm kev txhaj tshuaj intramuscular rau cov txiv neej hypogonadal. Yim tus neeg mob Klinefelter's syndrome tau txais 500 mg lossis 1, 000 mg ntawm TU los ntawm kev txhaj tshuaj intramuscular; 3 lub hlis tom qab, lwm koob tau muab rau txhua tus txiv neej (tshwj tsis yog rau ib tus, uas tsis tau txais 1,000-mg koob). Cov qib ntawm cov tshuaj hormones hauv cov poj niam cev xeeb tub tau ntsuas nyob rau ib ntus ua ntej thiab tom qab txhaj tshuaj. Qhov nruab nrab hauv cov ntshav T qib nce siab thaum kawg ntawm thawj lub lim tiam, los ntawm tsawg dua 10 nmol / L rau 47.8 ntxiv /-10.1 thiab 54.2 ntxiv /-4.8 nmol / L rau qis thiab koob tshuaj ntau dua, feem.

Tom qab ntawd, cov ntshav T qib tau qis zuj zus thiab mus txog qhov qis-ib txwm txwv rau cov txiv neej laus los ntawm hnub 50 txog 60. Pharmacokinetic tsom xam pom qhov kev tshem tawm ib nrab ntawm lub neej ntawm 18.3 ntxiv /-2.3 thiab 23.7 ntxiv /-2.7 hnub thiab pom lub sijhawm nyob hauv nruab nrab ntawm 21.7 ntxiv /-1.1 thiab 23.0 ntxiv /-0.8 hnub rau cov koob tshuaj qis dua thiab siab dua, feem. Cov cheeb tsam nyob rau hauv cov ntshav T concentration-lub sij hawm nkhaus thiab T-kev faib tus nqi cuam tshuam nrog cov ntshav T concentration tau nce siab dua tom qab 1,{23}}mg koob dua li tom qab koob tshuaj 500-mg. Qhov koob tshuaj 500-mg, thaum muab raws li kev txhaj tshuaj thib ob, tau txais txiaj ntsig zoo ntawm cov tshuaj pharmacokinetics (txhais tau tias qhov siab tshaj T qhov tseem ceeb tsis tshaj li qhov ib txwm muaj thiab kev pheej hmoo ntawm qib ib txwm muaj tsawg kawg 7 lub lis piam), qhia tias rov txhaj tshuaj ntawm 500 mg. ntawm 6-8-lub lim tiam ib ntus tuaj yeem muab qhov zoo tshaj plaws T hloov. Qhov nruab nrab ntawm cov ntshav estradiol tau normalized tom qab txhaj tshuaj, thiab cov qib prolactin yog ib txwm nyob rau hauv txoj kev tshawb no. Qhov tseem ceeb txo qis ntawm cov ntshav luteinizing hormone (LH) thiab follicle-stimulating hormone (FSH) qib tau pom, nrog rau qhov txo qis hauv LH ntau dua. Tsis muaj qhov sib txawv tseem ceeb hauv qib ntshav LH thiab FSH ntawm ob koob tshuaj. Kev sib deev hormone-binding globulin (SHBG) qib ua ntej kev kho T tau nyob ze ntawm qhov txwv ntawm ib txwm muaj rau cov txiv neej laus thiab raug txo los ntawm kwv yees li 50 feem pua ​​​​ua ntej koob thib ob ntawm TU.

Qhov txo qis SHBG qib uas tsim los ntawm thawj TU txhaj tshuaj tuaj yeem ua rau txo qis tag nrho cov qib T thiab kom nrawm dua ntawm T tom qab txhaj tshuaj TU thib ob. Peb xaus lus tias kev txhaj tshuaj ib zaug ntawm TU rau cov txiv neej hypogonadal tuaj yeem tswj cov ntshav T concentration nyob rau hauv ib txwm muaj tsawg kawg yog 7 lub lis piam yam tsis muaj kev phiv tshwm sim tam sim ntawd. Nws zoo li daim ntawv no ntawm T yuav tsum tau txhaj tshuaj tsuas yog ntawm 6-8- lub lim tiam lossis ntev dua, tsis yog nyob rau ntawm 2- lub limtiam lub sijhawm tsim nyog nrog tam sim no siv T esters (enanthate thiab cypionate). Qhov kev txhaj tshuaj TU no tuaj yeem muab kev kho kom zoo dua qub rau txiv neej hypogonadism thiab, ntxiv rau, tuaj yeem tsim los ua ib qho androgen tivthaiv ntawm txiv neej cov tshuaj tiv thaiv kab mob.

 

 

 

Testosterone undecanoate yog qhia rau testosterone hloov kho nyob rau hauv cov neeg laus cov txiv neej rau tej yam kev mob txuam nrog ib tug deficiency los yog tsis muaj endogenous testosterone. Cov xwm txheej no suav nrog:

Congenital los yog kis tau tus thawj hypogonadism: testicular tsis ua hauj lwm vim cryptorchidism, ob tog torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter's syndrome, tshuaj kho mob, los yog tshuaj lom puas tsuaj los ntawm cawv los yog hlau hnyav. Cov txiv neej no feem ntau muaj cov tshuaj hormones testosterone tsawg thiab gonadotropins (follicle-stimulating hormone FSH, luteinizing hormone LH) saum toj no ntau yam.

Congenital lossis kis tau tus mob hypogonadotropic hypogonadism: gonadotropin lossis luteinizing hormone-releasing hormone (LHRH) deficiency lossis pituitary-hypothalamic raug mob los ntawm qog nqaij hlav, raug mob, lossis hluav taws xob. Cov txiv neej no muaj cov tshuaj testosterone tsawg tsawg tab sis muaj gonadotropins nyob rau hauv ib txwm lossis tsawg.

Testosterone undecanoate tsis siv los kho cov hnub nyoog ntsig txog hypogonadism.

 

 

Testosterone yog ib qho tseem ceeb ntawm txiv neej cov tshuaj hormones uas yog lub luag haujlwm rau kev loj hlob thiab kev loj hlob ntawm cov txiv neej pw hauv nruab nrog cev thiab kev saib xyuas cov yam ntxwv ntawm kev sib deev, xws li kev loj hlob thiab kev loj hlob ntawm cov txiv neej poj niam cev xeeb tub, kev loj hlob ntawm txiv neej cov plaub hau faib, suab qaum thickening. , thiab kev hloov pauv hauv lub cev musculature thiab rog faib. Txiv neej hypogonadism, uas tshwm sim los ntawm qhov tsis txaus testosterone secretion, muaj ob lub ntsiab lus tseem ceeb: thawj hypogonadism yog tshwm sim los ntawm qhov tsis xws luag hauv gonads, qhov thib ob hypogonadism yog qhov tsis ua haujlwm ntawm hypothalamus (los yog pituitary) los tsim cov gonadotropins txaus (FSH thiab LH).

Hauv kev ncig, testosterone undecanoate yog cleaved los ntawm endogenous non-specific esterases tso tawm testosterone, lub active tivthaiv ntawm lub compound. Lub undecanoate sab saw yog pharmacologically inactive. Testosterone tuaj yeem hloov pauv ntxiv los ntawm 5 reductase rau nws daim ntawv ua haujlwm lom neeg ntau dua, dihydrotestosterone (DHT). Kev ua ntawm testosterone thiab DHT yog kho los ntawm androgen receptor, uas tau nthuav dav hauv ntau cov ntaub so ntswg, nrog rau cov pob txha, cov leeg, prostate, thiab cov ntaub so ntswg adipose. Testosterone khi rau androgen receptors nrog siab affinity thiab tswj lub hom phiaj gene transcription koom nrog nyob rau hauv ib txwm kev loj hlob thiab kev loj hlob ntawm cov txiv neej poj niam lub cev nqaij daim tawv thiab kev saib xyuas ntawm lwm yam kev sib deev yam ntxwv. prostate loj, thiab kev hloov hauv lipid profiles.

 

 

Cov npe lag luam	TU; Testosterone undecylate; Testosterone 17 -undecanoate; ORG-538; CLR -610
CAS	5949-44-0
Molar loj	456.711
MF	C30H48O3
Purity	Tshaj 98 feem pua
Yam khoom	Lub teeb daj roj

 

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Testosterone undecanoate yog ib tug ntev-acting ester ntawm testosterone uas yog siv rau cov tshuaj hormone hloov kho nyob rau hauv cov txiv neej uas tsis muaj testosterone qib. Thaum testosterone undecanoate tuaj yeem ua rau cov leeg loj hlob thiab muaj peev xwm txhim kho kev ua kis las, nws cov teebmeem feem ntau pom hauv cov tib neeg uas tsis tshua muaj testosterone ntau dua li cov neeg noj qab haus huv.

Nov yog li cas testosterone undecanoate tuaj yeem cuam tshuam rau cov leeg nqaij:

Restoring Testosterone Levels: Testosterone yog ib qho tshuaj hormones tseem ceeb uas ua lub luag haujlwm tseem ceeb hauv kev txhawb nqa cov leeg nqaij protein synthesis thiab tag nrho cov leeg nqaij. Hauv cov tib neeg uas tsis muaj qib testosterone tsawg, cov tshuaj hormone hloov kho nrog testosterone undecanoate tuaj yeem kho testosterone rau ntau qhov qub, uas tuaj yeem txhawb cov leeg nqaij.

Enhanced Protein Synthesis: Testosterone yog ib qho tshuaj anabolic uas pab txhawb cov protein synthesis hauv cov leeg. Cov qib testosterone txaus tuaj yeem ua rau muaj protein ntau synthesis, ua rau cov leeg nqaij kho thiab loj hlob.

Lub zog thiab kev ua tau zoo: Testosterone undecanoate, los ntawm kev nce qib testosterone, tuaj yeem ua rau kev txhim kho lub zog, kev ua siab ntev, thiab kev ua kis las. Cov kev txhim kho no tuaj yeem cuam tshuam ncaj qha rau cov leeg nqaij thiab.

Lub Cev Muaj Zog: Cov qib testosterone txaus tuaj yeem cuam tshuam cov roj faib thiab lub cev muaj pes tsawg leeg. Txo cov rog hauv lub cev feem pua ​​tuaj yeem pab qhia thiab txhim kho cov leeg txhais.

Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov cuam tshuam ntawm testosterone undecanoate ntawm cov leeg kev loj hlob yog cov ntsiab lus nyob ntawm:

Kev Teb Tus Kheej: Cov lus teb rau kev kho testosterone tuaj yeem sib txawv ntawm ib tus neeg mus rau lwm tus. Cov yam ntxwv xws li noob caj noob ces, kev noj haus, kev tawm dag zog niaj hnub, thiab kev noj qab haus huv tag nrho ua lub luag haujlwm hauv kev txiav txim siab seb cov leeg nqaij loj hlob thiab kev ua tau zoo li cas.

Kev Noj Qab Haus Huv Status: Testosterone undecanoate yog tshuaj rau cov tib neeg uas tsis tshua muaj testosterone qib vim muaj mob. Nws tsis yog feem ntau tau sau tseg rau cov tib neeg noj qab haus huv nrhiav cov leeg nqaij, thiab kev tswj hwm tus kheej rau cov laj thawj zoo li no tau poob siab vim muaj kev pheej hmoo thiab cov kev mob tshwm sim.

Kev Saib Xyuas Kev Siv: Yog tias koj muaj qib testosterone tsawg thiab tab tom xav txog kev hloov pauv testosterone, nws tseem ceeb heev uas yuav tau ua haujlwm ze nrog tus kws kho mob tsim nyog. Lawv tuaj yeem saib xyuas koj qhov kev nce qib, kho cov koob tshuaj yog tias tsim nyog, thiab xyuas kom meej tias txhua qhov kev pheej hmoo lossis kev mob tshwm sim raug txo qis.

Hauv cov ntsiab lus, thaum testosterone undecanoate tuaj yeem pab txhawb rau cov leeg nqaij thiab kev ua tau zoo hauv cov tib neeg uas tsis muaj testosterone qib, nws tsis pom zoo siv los ntawm cov tib neeg noj qab haus huv nkaus xwb tab tom nrhiav kev tsim cov leeg. Nco ntsoov saib xyuas koj txoj kev noj qab haus huv thiab kev nyab xeeb los ntawm kev nrhiav cov kws kho mob cov lus qhia ua ntej txiav txim siab txhua hom kev kho tshuaj hormonal lossis tshuaj ua kom muaj txiaj ntsig zoo.

 

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