Testosterone Undecanoate 250mg Rau Bodybuilding CAS:5949-44-0

Testosterone undecanoate yog cov ester prodrug ntawm testosterone thiab muaj ib nrab-chain fatty acid nyob rau hauv cov pa roj carbon 17 txoj hauj lwm.6 Nws tau tsim los ntawm fatty acid esterification ntawm testosterone thiaj li ua tiav qhov ncauj tswj testosterone.2 Muaj qhov ncauj thiab intramuscular formulations muaj rau testosterone. undecanoate: ob qho tib si formulations yog qhia rau testosterone hloov kho nyob rau hauv cov laus cov txiv neej nrog hypogonadism.

Testosterone yog ib qho tseem ceeb ntawm txiv neej cov tshuaj hormones uas yog lub luag haujlwm rau kev loj hlob thiab kev loj hlob ntawm cov txiv neej hauv nruab nrog cev thiab kev saib xyuas cov yam ntxwv ntawm kev sib deev theem nrab. Txiv neej hypogonadism, tshwm sim los ntawm tsis txaus testosterone secretion, tuaj yeem ua rau cov tsos mob thiab cov tsos mob ntawm testosterone deficiency, xws li txo libido, erectile kawg, thiab poob ntawm cov leeg thiab pob txha loj. Testosterone hloov kho lub hom phiaj los kho cov theem ntawm testosterone, yog li txhim kho cov tsos mob thiab cov tsos mob ntawm testosterone deficiency.

 

 

Testosterone undecanoate yog qhia rau testosterone hloov kho nyob rau hauv cov neeg laus cov txiv neej rau tej yam kev mob txuam nrog ib tug deficiency los yog tsis muaj endogenous testosterone. Cov xwm txheej no suav nrog:

● Congenital lossis kis tau tus mob thawj hypogonadism: testicular tsis ua hauj lwm vim cryptorchidism, ob tog torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter's syndrome, chemotherapy, los yog tshuaj lom puas tsuaj los ntawm cawv los yog hlau hnyav. Cov txiv neej no feem ntau muaj cov tshuaj hormones testosterone tsawg thiab gonadotropins (follicle-stimulating hormone FSH, luteinizing hormone LH) saum toj no ntau yam.

● Congenital lossis kis tau tus mob hypogonadotropic hypogonadism: gonadotropin los yog luteinizing hormone-releasing hormone (LHRH) deficiency los yog pituitary-hypothalamic raug mob los ntawm qog nqaij hlav, raug mob, los yog hluav taws xob. Cov txiv neej no muaj cov tshuaj testosterone tsawg tsawg tab sis muaj gonadotropins nyob rau hauv ib txwm lossis tsawg.

Testosterone undecanoate tsis siv los kho cov hnub nyoog ntsig txog hypogonadism.

Ib zaug nyob rau hauv kev ncig, testosterone undecanoate yog cleaved los tso testosterone, uas kho ntau yam kev ua lom. Testosterone yog ib qho endogenous txiv neej cov tshuaj hormones uas ua lub luag haujlwm tseem ceeb hauv kev sib deev ntawm txiv neej: nws koom nrog kev tswj hwm ntawm hematopoiesis, lub cev muaj pes tsawg leeg, thiab cov pob txha metabolism. Raws li kev hloov tshuaj hormones, testosterone undecanoate yog ib qho exogenous ntawm testosterone hauv cov txiv neej nrog hypogonadism. Testosterone therapy aims los txhim kho cov tsos mob thiab cov tsos mob ntawm testosterone deficiency nrog rau txo libido, erectile kawg, thiab poob ntawm cov leeg nqaij thiab pob txha loj.

Testosterone muaj cov tshuaj tswj hwm hauv Teb Chaws Asmeskas vim muaj kev tsim txom los ntawm cov neeg ncaws pob thiab cov kws tsim lub cev. Kev siv cov tshuaj testosterone ntau dua li kev pom zoo tuaj yeem ua rau cov tsos mob tshem tawm mus ntev li ob lub lis piam lossis ntau hli. Kev tshem tawm cov tsos mob muaj xws li kev nyuaj siab, kev nyuaj siab loj, qaug zog, xav, tsis xis nyob, chim siab, anorexia, insomnia, txo libido, thiab hypogonadotropic hypogonadism.

Testosterone tuaj yeem ua rau hirsutism, virilization, sib sib zog nqus ntawm lub suab, clitoral o, lub mis atrophy, txiv neej-hom baldness, thiab kev coj khaub ncaws tsis zoo thaum siv rau cov poj niam. Kev siv rau cov tub ntxhais hluas tuaj yeem ua rau lub sijhawm ntxov kaw ntawm cov pob txha epiphyses nrog kev txiav tawm ntawm kev loj hlob thiab kev puberty precocious.

Testosterone yog ib qho tseem ceeb ntawm txiv neej cov tshuaj hormones uas yog lub luag haujlwm rau kev loj hlob thiab kev loj hlob ntawm cov txiv neej pw hauv nruab nrog cev thiab kev saib xyuas cov yam ntxwv ntawm kev sib deev, xws li kev loj hlob thiab kev loj hlob ntawm cov txiv neej poj niam cev xeeb tub, kev loj hlob ntawm txiv neej cov plaub hau faib, suab qaum thickening. , thiab kev hloov pauv hauv lub cev musculature thiab rog faib. Txiv neej hypogonadism, uas tshwm sim los ntawm qhov tsis txaus testosterone secretion, muaj ob lub ntsiab lus tseem ceeb: thawj hypogonadism yog tshwm sim los ntawm qhov tsis xws luag hauv gonads, qhov thib ob hypogonadism yog qhov tsis ua haujlwm ntawm hypothalamus (los yog pituitary) los tsim cov gonadotropins txaus (FSH thiab LH).

Hauv kev ncig, testosterone undecanoate yog cleaved los ntawm endogenous non-specific esterases tso tawm testosterone, lub active tivthaiv ntawm lub compound. Lub undecanoate sab saw yog pharmacologically inactive. Testosterone tuaj yeem hloov pauv ntxiv los ntawm 5 reductase rau nws daim ntawv ua haujlwm lom neeg ntau dua, dihydrotestosterone (DHT). Kev ua ntawm testosterone thiab DHT yog kho los ntawm androgen receptor, uas tau nthuav dav hauv ntau cov ntaub so ntswg, nrog rau cov pob txha, cov leeg, prostate, thiab cov ntaub so ntswg adipose. Testosterone khi rau androgen receptors nrog siab affinity thiab tswj lub hom phiaj gene transcription koom nrog nyob rau hauv ib txwm loj hlob thiab kev loj hlob ntawm cov txiv neej pw nruab nrog cev thiab kev saib xyuas ntawm lwm yam kev sib deev yam ntxwv. Testosterone tuaj yeem ua rau kev ua haujlwm ntawm kev sib deev, nce lean lub cev loj, pob txha ceev, erythropoiesis, prostate loj, thiab hloov pauv hauv lipid profile.

Testosterone undecanoate yog lipophilic molecule uas yog absorbed rau hauv plab hnyuv lymphatic system tom qab noj qhov ncauj. Tom qab ntawd nws raug tso tawm mus rau hauv cov hlab ntsha dav dav los ntawm txoj hlab ntsws, yog li hla lub portal ncig thiab thawj-dhau metabolism hauv lub siab, tsis zoo li endogenous testosterone.

Tom qab kev tswj hwm qhov ncauj ntawm 237 mg ob zaug hauv ib hnub hauv cov txiv neej nrog hypogonadism, qhov nruab nrab (SD) C_maxyog 1008 (581) ng/dL. T_maxyog li tsib teev tom qab kev tswj qhov ncauj. Kev txo qis ntawm testosterone raug pom thaum noj tsis muaj zaub mov.

Tom qab kev tswj hwm intramuscular ntawm 750 mg testosterone undecanoate, cov ntshav ntshav testosterone ntau tau mus txog qhov siab tshaj plaws tom qab qhov nruab nrab ntawm xya hnub (ntau ntawm plaub mus rau 42 hnub), uas tom qab ntawd maj mam poob qis. Qhov nruab nrab (SD) C_maxyog li ntawm 90.9 (68.8) ng / dL nyob rau hnub plaub tom qab txhaj tshuaj testosterone undecanoate. Steady-state serum testosterone concentration tau ua tiav nrog kev txhaj tshuaj thib peb ntawm 14 lub lis piam. Thaum 42 hnub tom qab txhaj tshuaj, Testosterone undecanoate yuav luag tsis tuaj yeem kuaj pom.

Kev tshem tawm ib nrab-lub neej ntawm testosterone undecanoate yog kwv yees li ob teev. Thaum testosterone tsim los ntawm testosterone undecanoate, ib nrab ntawm lub neej ntawm testosterone tuaj yeem sib txawv thiab cov txiaj ntsig tau tshaj tawm hauv cov ntaub ntawv tseem tsis sib xws, txij li 10 txog 100 feeb. Testosterone undecanoate hauv cov roj castor rau kev txhaj tshuaj intramuscular muaj ib nrab ntawm lub neej ntawm 33.9 hnub, tso cai rau nws tswj cov qib ntshav hauv qhov qub ntau tshaj 6 lub lis piam.

Cov npe lag luam	Qhov ncauj: Kyzatrex, Andriol, Jatenzo IM: Aved, Nebido TU; Testosterone undecylate; CLR -610 Testosterone 17 -undecanoate; ORG-538;
CAS	5949-44-0
Molar loj	456.711
Formula	C30H48O3
Purity	Tshaj 98%
Yam khoom	250 mg/ml

 

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Testosterone decanoate yog ib daim ntawv ntawm Testosterone, uas yog ib tug natural txiv neej hormone (androgen) ua los ntawm cov noob qes. Testosterone decanoate yog ib daim ntawv esterified ntawm testosterone, lub ntsiab lus nws tau hloov kho kom raug tso tawm qeeb dua rau hauv cov hlab ntsha tom qab txhaj tshuaj.

Testosterone thiab nws cov esters xws li testosterone decanoate muaj ntau yam kev kho mob, suav nrog:

1.Hormone Replacement Therapy (HRT): Testosterone replacement therapy yog siv los kho cov mob uas lub cev tsis tsim cov testosterone txaus, xws li hypogonadism (tsawg testosterone qib). Testosterone decanoate, nrog rau lwm yam testosterone esters, tuaj yeem siv los ntawm kev txhaj tshuaj los kho cov qib testosterone kom zoo li qub.

2.Delayed Puberty: Hauv cov tub ntxhais hluas uas muaj hnub nyoog laus dua, kev kho testosterone yuav raug muab tshuaj los txhawb kev laus thiab txhawb kev loj hlob ntawm kev sib deev yam ntxwv xws li lub ntsej muag plaub hau loj hlob, kev sib sib zog nqus ntawm lub suab, thiab kev loj hlob ntawm cov leeg.

3.Gender Affirmation Therapy: Testosterone therapy tej zaum yuav yog ib feem ntawm kev kho poj niam txiv neej affirmation rau cov txiv neej transgender induce masculinization, nrog rau kev loj hlob ntawm cov txiv neej theem nrab kev sib deev yam ntxwv.

4.Muscle Wasting Conditions: Testosterone, suav nrog Testosterone decanoate, tau siv rau hauv kev kho mob ntawm qee yam nqaij nkim, xws li HIV / AIDS-txog nkim syndrome lossis lwm yam mob uas cuam tshuam nrog cov nqaij ntshiv loj.

5. Mob Cancer: Qee zaum, testosterone yuav siv tau rau kev kho mob qog noj ntshav hauv cov poj niam, tshwj xeeb tshaj yog cov qog nqaij hlav cancer yog cov tshuaj hormone receptor-zoo.

 

 

 

 

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