STROMUSC Stanozolol Dej 50mg/ml Rau Lub Cev Muaj Zog CAS: 10418-03-8

   Lub Compound Nws tus kheej: Dab tsi ua rau Dej Suspension Unique

Stanozolol yog ib qho hluavtaws anabolic-androgenic steroid muab los ntawm dihydrotestosterone (DHT), thawj zaug los ntawm Winthrop Laboratories hauv xyoo 1962. Dab tsi cais nws los ntawm yuav luag txhua lwm yam tshuaj anabolic steroid nyob rau hauv kev ua lag luam yog ib qho tseeb qauv: nws tsis yog esterified. Qhov twg testosterone, nandrolone, thiab trenbolone vam khom rau fatty acid esters kom maj mam tso tawm ntawm qhov chaw txhaj tshuaj, stanozolol yog xa raws li micronized crystals raug tshem tawm hauv aqueous (dej{3}}raws li) tsheb.

Qhov txawv ntawd tsis yog tshuaj pleev ib ce. Nws pib hloov cov tshuaj coj li cas. Tus hwm - hom dej ncua kev kawm ntawv ntawm 50 mg / mL muaj stanozolol microparticles uas, ib zaug txhaj intramuscularly, yaj maj mam los ntawm cov khoom hauv lub xeev. Vim tias tsis muaj ester rau cleave, tus nqi - txwv cov kauj ruam yog kev tawg ntawm cov crystals lawv tus kheej es tsis yog enzymatic hydrolysis ntawm ib daim ntawv cog lus ester. Qhov no ua rau kev nqus cov profile uas sai dua thaum pib dua cov roj -raws li esters tab sis nrog lub davhlau ya nyob twg tshem tawm tus Tsov tus tw uas tuaj yeem txuas ntxiv ntev dua li qhov nominal ib nrab -lub neej qhia.

Lub molecule nws tus kheej yog ib tug 17 -alkylated DHT derivative nrog ib tug pyrazole nplhaib fused rau lub A- nplhaib, yielding cov mis C₂₁H₃₂N₂O. Qhov kev hloov kho pyrazole no yog lub luag haujlwm rau cov khoom siv tshuaj txawv txawv. Nws muab qhov ncauj bioavailability thaum tib lub sijhawm hloov pauv receptor khi cov yam ntxwv - stanozolol nthuav tawm cov txheeb ze kev sib raug zoo rau tib neeg androgen receptor tsuas yog nyob ib ncig ntawm 0.8%, tab sis paradoxically tsim muaj zog androgen receptor- mediated signaling hauv vivo. Qhov siab anabolic-rau-androgenic piv (kwv yees li 320: 30 txheeb ze rau methyltestosterone) txhais tau hais tias cov khoom sib xyaw ua rau cov nitrogen tuav thiab cov protein synthesis nrog kev sib piv ntawm cov lus qhia androgenic hauv cov ntaub so ntswg.

Kev ua lag luam hauv av yog saturated nrog stanozolol tshem tawm ntawm wildly variable zoo, thiab qhov sib txawv ntawm cov khoom hwm thiab ib pob nyiaj siv tsis yog kev lag luam ntawv tseeb. Ob yam cais lawv: particle loj thiab lub tsheb muaj pes tsawg leeg.

Lub ncua kev kawm micronized zoo muaj stanozolol crystals nyob rau hauv qis -micrometer range. Particle loj ncaj qha dictates ob qho tib si txhaj tshuaj thiab nqus kinetics. Cov pob zeb loj dua tuaj yeem txhaws me dua - ntsuas koob, tsim cov palpable nodules ntawm qhov chaw txhaj tshuaj, thiab yaj tsis sib npaug. Cov tuam txhab lag luam hwm nqis peev hauv cov khoom siv micronization uas ua rau muaj qhov sib xws, nqaim particle- qhov loj me. Qhov txiaj ntsig zoo rau cov neeg siv yog tias 25-gauge koob tuaj yeem kos thiab txhaj tshuaj tsis tas yuav rov ua dua, thiab cov depot dissolves nrog kev kwv yees ntau dua.

Lub tsheb aqueous yog qhov sib txawv thib ob. Bacteriostatic dej uas muaj kwv yees li 1% benzyl cawv yog tus qauv rau kev tiv thaiv kab mob kev loj hlob tom qab thawj zaug nres. Veterinary- qib formulations keeb kwm tau khiav ntau dua ntawm benzyl cawv, uas ua rau cov yam ntxwv tom qab- txhaj tshuaj hlawv. Tus neeg hwm hwm - qib kev npaj yuav mus rau qhov qis kawg ntawm qhov kev lees paub, txo qis kev txhaj tshuaj- qhov chaw khaus khaus yam tsis muaj kev cuam tshuam rau kev tsis muaj menyuam. Qee qhov kev npaj kuj tseem suav nrog polysorbate 80 lossis cov surfactants zoo sib xws los tswj cov khoom siv lead ua kev sib raug zoo, tiv thaiv "1/3 dawb sediment, 2/3 dej ntshiab" sib cais uas qhia txog cov khoom tsim tawm tsis zoo.

Dej-raws li kev tshem tawm muaj kev txhaj tshuaj ntau dua- qhov chaw txaus ntshai tshaj li roj- raws li esters. Intramuscular abscesses thiab granulomatous cov tshuaj tiv thaiv yog cov ntaub ntawv muaj teeb meem, tshwj xeeb tshaj yog thaum cov txheej txheem sterile tsis zoo los yog cov khoom muaj paug. Qhov no tsis yog vim li cas thiaj li tshem tawm daim ntawv txhaj tshuaj, tab sis nws yog ib qho laj thawj los kho qhov chaw npaj thiab kev huv huv ntawm rab koob nrog qhov hnyav dua li ib qho kev npaj roj tsis muaj menyuam.

Cov dej ncua kev kawm ntawv yog ib qho tshwj xeeb hauv kev txhim kho lub cev, thiab kev nkag siab tias niche yuav tsum tau nkag siab tias qhov sib txuas ua rau lub cev tsis zoo dua li cov neeg siv tau tshaj tawm anecdotally.

Stanozolol tus yam ntxwv tshwj xeeb tshaj plaws hauv kev tsim lub cev yog nws cov txiaj ntsig ntawm kev sib deev hormone-binding globulin (SHBG). Nws yog ib qho ntawm cov muaj zog tshaj plaws SHBG suppressors nyob rau hauv tag nrho cov anabolic steroid catalog. Ib chav kawm 14-hnub ntawm 10 mg txhua hnub hauv cov txiv neej noj qab haus huv ua rau 55% txo qis hauv cov ntshav testosterone, nrog rau kev txo qis hauv testosterone dawb, SHBG, thiab luteinizing hormone. Lub SHBG kev tawm tsam tsis yog tsuas yog ib qho kev mob tshwm sim - nws yog lub tswv yim los ntawm stanozolol amplifies cov dej num ntawm kev sib koom ua ke. Thaum SHBG raug tsav los, ib feem loj ntawm kev ncig ntawm testosterone (txawm hais tias endogenous lossis exogenous) tseem tsis muaj zog thiab ua haujlwm lom. Qhov no ua rau qhov sib xyaw ua kom muaj zog sib npaug hauv ib pawg es tsis yog tus tsim tsim ib leeg.

Qhov "qhuav" tsos uas cov neeg siv caum yog qhov tshwm sim ncaj qha ntawm cov molecule tsis muaj peev xwm ua kom aromatize. Raws li DHT derivative, stanozolol tsis tuaj yeem hloov mus rau estrogen los ntawm aromatase enzyme. Tsis muaj tshuaj estrogen- kho cov dej tuav, tsis muaj cov kua dej subcutaneous puffiness, tsis muaj gynecomastia siab. Dab tsi tseem tshuav yog lub cev uas zoo li nyuaj thiab vascular vim tias cov txheej txheem subcutaneous tsis tuav dej. Cov tshuaj tseem txhawb nqa erythropoietin ntau lawm, ua kom cov ntshav liab loj thiab ua rau lub vascular tsos los ntawm kev siab hematocrit es tsis yog vasodilation ib se.

Qhov kev nkag siab tsis zoo tshaj plaws ntawm kev siv stanozolol yog mob pob qij txha. Cov lus piav qhia dav dav - "nws dries tawm koj cov pob qij txha" - yog imprecise. Cov txheej txheem tiag tiag cuam tshuam nrog kev tiv thaiv - ib puag ncig estrogenic qhov chaw tsim. Estrogen plays lub luag haujlwm hauv kev tswj cov kua dej synovial viscosity thiab pob txha mos noj qab haus huv. Thaum stanozolol suppresses estrogenic kev ua si (ob qho tib si los ntawm qhov tsis muaj aromatization thiab los ntawm central suppression ntawm endogenous ntau lawm), synovial kua ntau lawm yuav poob, txo kev sib koom tes lubrication.

Paradoxically, stanozolol kuj txhawb nqa collagen synthesis thiab tau pom tias muaj kev tiv thaiv los tiv thaiv - cov teebmeem ntawm synoviocytes thiab chondrocytes hauv intra- cov chaw tshawb fawb articular. Hauv cov qauv tsiaj ntawm osteoarthritis, intra-articular stanozolol txo qis kev tsim osteophyte thiab txhawb kev tsim pob txha mos. Txawm li cas los xij, tus qauv siv lub cev tsim lub cev, tsis rov ua dua cov txheej txheem hauv- kab mob sib kis. Cov txiaj ntsig zoo rau cov neeg siv feem ntau yog qhov chaw sib koom ua ke uas xav tias "qhuav" thiab creaky, tshwj xeeb tshaj yog nyob rau hauv lub xub pwg nyom, hauv caug, thiab lub luj tshib - cov qauv uas muaj qhov txwv vascularity thiab cov neeg kho tshuab siab.

Qhov kev tsis sib haum xeeb no tsis yog kev ntxhov siab xwb. Nws qhia txog kev txo qis kev nqus ntawm lub sijhawm thaum lub zog tso zis tau nce siab thiab kev cob qhia hnyav. Tendon thiab ligament raug mob yuav nce tsis yog vim stanozolol tsis muaj zog cov ntaub so ntswg ncaj qha, tab sis vim hais tias lub load - bearing peev xwm ntawm lub pob qij txha raug cuam tshuam thaum lub cev muaj peev xwm los tsim kom muaj zog.

Kev txhaj tshuaj stanozolol raug ncua ntawm 50 mg txhua hnub rau cov txiv neej cov neeg siv, ib qho qauv uas qhia txog kev nqus cov kinetics los ntawm aqueous depot es tsis yog nws cov ntshav ib nrab -lub neej. Qhov nominal ib nrab- lub neej feem ntau raug suav hais tias yog kwv yees li 24 teev rau daim ntawv txhaj tshuaj, tab sis daim duab no yog kev dag. Lub davhlau ya nyob twg tshem tawm tus Tsov tus tw - lub sij hawm lub sij hawm lub sij hawm lub sij hawm lub sij hawm lub sij hawm lub sij hawm lub sij hawm nyob rau hauv uas cov kab mob tseem nyob detectable - ntev npaum li cas vim crystal dissolution txuas ntxiv rau hnub tom qab txhaj tshuaj.

Lub voj voog ntev rau daim ntawv txhaj tshuaj feem ntau yog 8 mus rau 10 lub lis piam, ntev tshaj li 6 mus rau 8 lub lis piam pom zoo rau cov ntsiav tshuaj hauv qhov ncauj vim tias lub chaw tso dej hauv dej muab cov ntaub ntawv tso tawm ntau dua nrog lub ncov tsawg dua -trough fluctuation. Lub compound yog yuav luag tsis khiav raws li ib tug solo voj voog. Nws SHBG-tshwj xeeb cov khoom ua rau nws yog ib qho kev sib koom ua ke rau lub hauv paus ntawm testosterone, qhov twg qhov nce siab dawb testosterone feem txhais ua cov nyhuv anabolic ntau dua los ntawm tib koob tshuaj testosterone.

Lub voj voog ua haujlwm zoo rau cov neeg siv nruab nrab tuaj yeem koom nrog testosterone ester khiav rau 10 mus rau 12 lub lis piam, nrog kev ncua stanozolol qhia thaum kawg 6 txog 8 lub lis piam. Lub sijhawm no siv cov khoom sib xyaw ua ke "tiav" cov yam ntxwv - cov tawv tawv thiab vascularity cuam tshuam pom tau raws li cov dej subcutaneous los ntawm testosterone raug tshem tawm thiab SHBG kev tawm tsam ua rau cov tshuaj dawb dawb. Lub stanozolol yuav tsum tsis txhob khiav dhau los ntawm qhov chaw uas lub hauv paus testosterone raug tso tseg; qhov tsis muaj lub hauv paus compound nyob rau hauv lub cev thaum SHBG tseem suppressed tsim ib qho tsis zoo hormonal ib puag ncig.

Ib nrab -kev sib tham nyob ib ncig ntawm stanozolol ncua kev kawm ntawv yog qhov uas cov pa tshuaj pharmacokinetic framing tawg. Plasma tshem tawm ib nrab- lub neej qhov tseem ceeb ntawm 4 mus rau 12 teev tau tshaj tawm hauv kev tshawb fawb kws kho tsiaj tom qab intra-articular tswj, tab sis cov duab no piav qhia txog kev tshem tawm cov tshuaj yaj yeeb los ntawm cov ntshav ntshav, tsis yog kev tso tshuaj los ntawm kev txhaj tshuaj. Qhov chaw kho mob muaj feem cuam tshuam ib nrab-lub neej - ib qho uas tswj hwm kev siv tshuaj ntau zaus thiab kuaj pom qhov rais - ntev dua vim tias tus nqi- txwv cov kauj ruam yog crystal dissolution.

Kev kuaj zis ntawm stanozolol metabolites tuaj yeem nyob ntawm 10 hnub tom qab ib koob tshuaj ntawm qhov ncauj mus rau 8 lub lis piam lossis ntev dua tom qab siv cov tshuaj txhaj. Rau cov dej ncua kev kawm tshwj xeeb, qee qhov chaw qhia txog kev tshawb nrhiav qhov rais txuas ntxiv mus txog peb lub hlis tom qab txhaj tshuaj kawg. Cov metabolite tau soj ntsuam hauv kev tswj hwm doping, stanozolol-1'N-glucuronide, tuaj yeem kuaj pom tau ntev dua 12 hnub tom qab ib koob tshuaj 5 mg ntawm qhov ncauj. Cov ntsia hlau thiab cov plaub hau tsom tuaj yeem txuas ntxiv qhov kev tshawb pom lub qab ntug mus rau 8 mus rau 12 lub hlis tom qab siv tas li.

Rau cov neeg siv lub cev tsim, qhov no muaj qhov cuam tshuam ncaj qha: qhov kev txhaj tshuaj raug ncua tsis yog qhov sib xyaw ua haujlwm yog tias kev sim tshuaj yog nyob qhov twg ntawm lub qab ntug. Lub qhov rai nrhiav pom yog ntsuas hauv lub hlis, tsis yog hnub.

Stanozolol suppresses hypothalamic{0}}pituitary-testicular axis los ntawm kev tawm tswv yim tsis zoo ntawm qib hypothalamic thiab pituitary. Qhov kev tawm tsam yog koob tshuaj - nyob ntawm thiab lub sijhawm- nyob ntawm, thiab kev rov qab los tsis yog sai sai. Txawm tias tom qab kawm luv luv, cov qib testosterone hauv cov ntshav tuaj yeem siv sij hawm ntau lub lis piam kom rov qab mus rau qhov pib, thiab cov spermatogenesis rov qab tuaj yeem siv sijhawm ntau lub hlis.

PCT rau stanozolol- muaj lub voj voog yuav tsum pib tom qab ester los ntawm ib qho kev sib txuas nrog testosterone puag tau tshem tawm. Rau lub voj voog xaus nrog ntev -ester testosterone (enanthate lossis cypionate), uas txhais tau tias tos 10 mus rau 14 hnub tom qab qhov kawg ntawm kev txhaj tshuaj testosterone ua ntej pib PCT. Rau luv luv -ester puag (propionate lossis acetate), tos yog 3 mus rau 5 hnub.

Tus qauv SERM-raws li kev cai muaj xws li tamoxifen (Nolvadex) ntawm 40 mg txhua hnub rau ob lub lis piam tom qab 20 mg ib hnub rau ob lub lis piam ntxiv, lossis clomiphene (Clomid) ntawm 50 mg txhua hnub rau plaub lub lis piam. Qee qhov kev cai ua ntej - thauj khoom clomiphene ntawm 100 mg rau thawj lub lim tiam ua ntej poob rau 50 mg. Kev xaiv ntawm ob feem ntau yog tus kheej; tamoxifen zoo li yuav ua tau zoo dua nyob rau hauv cov nqe lus ntawm mus ob peb vas, thaum clomiphene yuav ua kom sai LH restoration ntawm tus nqi ntawm ntau cov kev mob tshwm sim rau qee cov neeg siv.

Dab tsi yog qhov txawv ntawm stanozolol PCT los ntawm tus qauv testosterone- tsuas yog PCT yog qhov tob ntawm kev tawm tsam thiab SHBG dynamic. Vim tias stanozolol tsav SHBG qis, cov kev kuaj mob rov qab los ntsib ob qhov kev sib tw: lawv yuav tsum rov pib dua testosterone ntau lawm thaum lub binding globulin uas ib txwm tswj hwm cov tshuaj hormones dawb tseem raug txwv. Qhov no tuaj yeem ua rau lub xeev ib ntus uas tag nrho cov testosterone zoo nkaus li qis hauv cov ntshav tab sis cov feem dawb yog qhov tsis txaus. Xyaum, qhov no txhais tau tias PCT yuav tsum tsis txhob txiav txim tsuas yog rau tag nrho cov lej testosterone; dawb Testosterone thiab LH yog cov ntaub ntawv qhia ntau dua thaum rov qab los.

Tsis muaj kev sib tham txog kev txhaj tshuaj stanozolol ua tiav yam tsis lees paub txog kev ua rau hepatotoxicity. Ob daim ntawv qhov ncauj thiab txhaj tshuaj yog 17 -alkylated, thiab lub siab ua haujlwm ntawm qhov sib txuas los ntawm tib txoj hauv kev tsis hais txog txoj kev tswj hwm. Daim ntawv txhaj tshuaj hla dhau ua ntej - dhau cov metabolism, uas qee cov neeg siv txhais tau tias nws yog "yooj yim dua rau daim siab." Qhov kev txhais ntawd yog questionable. Lub alkylation uas tiv thaiv cov molecule los ntawm hepatic degradation nyob rau hauv lub qhov ncauj ntsiab lus tseem ceeb loads hepatic clearance pathways thaum cov tshuaj tuaj txog ntawm lub systemic ncig. Peliosis hepatis - ntshav- puv hlwv hauv daim siab - thiab cholestatic jaundice yog cov ntaub ntawv muaj teeb meem ntawm kev siv stanozolol ntev, thiab cov mob ntawm daim siab ua haujlwm tsis zoo tom qab kev tswj hwm stanozolol tau tshaj tawm hauv cov ntaub ntawv kho mob.

Lub lipid profile yog qhov thib ob ntawm kev txhawj xeeb. Stanozolol ua rau cov kev hloov pauv tsis zoo tshaj plaws ntawm cov tshuaj anabolic steroid, txo qis HDL thiab nce LDL. Cov nyhuv no zoo li yog kho los ntawm tib txoj hauv kev hauv siab uas tswj cov kev tshem tawm ntawm qhov sib xyaw ua ke, ua rau nws cais tsis tau ntawm cov tshuaj ua haujlwm es tsis yog koob tshuaj - nyob ntawm cov kev mob tshwm sim uas tuaj yeem zam tau ntawm cov tshuaj tsawg.

Kev tshem tawm dej ntxiv kev txhaj tshuaj- tshwj xeeb txaus ntshai uas daim ntawv qhov ncauj tsis nqa: intramuscular abscess tsim, granulomatous cov tshuaj tiv thaiv, thiab muaj peev xwm ntawm "Winstrol hnoos" - ib ntus hnoos thiab xim hlau saj tam sim ntawd tom qab- txhaj tshuaj, tshwm sim los ntawm qhov chaw aqueous. Cov no tuaj yeem tswj tau nrog cov txheej txheem tsim nyog thiab kev npaj tsis muaj menyuam, tab sis lawv muaj tseeb thiab lawv nquag nquag nrog kev ncua ntau dua li cov roj-raws li cov khoom sib xyaw.

Hom	STROMUSC
Cov npe lag luam	Winstrol, Stromba, Androstanazol; Androstanazole; Stanazol; WIN-14833; NSC-43193; NSC-233046;
CAS	10418-03-8
Molar loj	328.500
Formula	C21H32N2O
Purity	Tshaj 98%
Yam khoom	50 mg/ml, 100 mg/ml

 

 

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Stanozolol ncua kev kawm ntawv tsis yog ib tug loj builder. Nws yuav tsis tsim qhov loj loj nce txuam nrog testosterone, deca, lossis anadrol. Nws lub luag hauj lwm yog architectural es tsis volumetric - nws qhia cov nqaij ntshiv uas twb muaj lawm los ntawm stripping subcutaneous dej thiab txo cov feem ntawm circulating hormone uas yog khi thiab inactive. Cov physiques uas saib impressive ntawm stanozolol zoo impressive vim hais tias lub hauv paus musculature yog tsim; lub compound tsuas tshem tawm cov txheej uas obscures nws.

Nws kuj tsis yog ib tug beginner compound. Kev txhaj tshuaj- qhov chaw pheej hmoo profile, hepatotoxicity, cov teebmeem lipid, thiab qhov tob ntawm HPTA kev tawm tsam txhua qhov kev sib cav rau tus neeg siv uas twb tau khiav testosterone- tsuas yog lub voj voog, nkag siab lawv tus kheej cov lus teb rau androgens, thiab muaj cov txheej txheem rau kev soj ntsuam ntshav thiab PCT. Cov dej ncua kev kawm ntawv yog ib qho cuab yeej meej rau ib theem tshwj xeeb ntawm kev txhim kho lub cev. Siv txoj kev ntawd, nws ua dab tsi tsis muaj qhov ncauj daim ntawv tuaj yeem rov ua dua raws li kev tso tawm thiab kev tawm tsam SHBG. Siv tsis tu ncua, nws ua rau mob pob qij txha, cov lipids tsis zoo, thiab cov kab mob endocrine cuam tshuam nrog lub sijhawm rov qab los ntsuas hauv lub hlis.

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