Tetracaine hmoov rau cov tshuaj loog hauv cheeb tsam li cas: 94-24-6

Nws yog dab tsi: tus tub ntxhais molecule

Tetracaine HCL (2 {{- (Dethylamino) Benylamino) yog muaj zog, ester-hom hom tshuaj loog hauv zos. Nyob rau hauv nws daim ntawv ntshiab ntshiab, nws yog ib qho zoo, dawb kom dim-dawb, tsw, crystalline khoom. Nws yog soluble nyob rau hauv dej, sib sau meej, tsis muaj xim, thiab kuj soluble hauv cawv thiab chloroform. Nws txhais cov cwj pwm yog cov ester txuas (txuas cov lipophilic ntawm hydrophilic tertiary amine) - qhov tseem ceeb rau nws cov metabolism thiab kev ua xua profile. Cov hmoov no yog cov khoom siv raw los ntawm qhov twg myriad customized kev npaj tshuaj ntsuab kev npaj yog crafted, feem ntau nyob rau hauv cov chaw muag tshuaj tshwj xeeb ua rau nruj me nyuam USP<795>thiab<797>Cov Lus Qhia.

 

● Qhov kawg Purity & conctration tswj:Raws li lub hauv paus muaj cov khoom xyaw, nws tso cai rau compounding pharpacists kom pib los ntawm kev paub tswj tau ntau tshaj plaws (tsis muaj kev tswj hwm qib siab

● Tsim Kom yooj yim:Cov hmoov yog tus yuam sij rau kev tsim bespoke npaj:

○ Cov kev daws teeb meem / gels:Rau corneal tshuaj loog (ophalmology), mucous membraneia (enent, arty), lossis cov txheej txheem tawv nqaij (dermatology} Feem ntau ua ke nrog lwm tus neeg sawv cev zoo li Lidocaine).

○ Ointments & cream:Muab kev tso tawm kom tau txais kev tso tawm saum toj kom loog lossis tswj cov xwm txheej zoo li mob txhab mob.

○ Noob / PaS:Rau qhov dav, txawm tias thov rau ntawm cov chaw loj lossis tsis xwm yeem ntawm cov chaw (piv txwv li, qhov ncauj, qhov ntswg).

Cov lus sib xyaw ua ke:"Khawv koob" lossis "blt" cocktails (piv txwv li, lidocaine 8%, tetracaine 4% lossis 6%) rau cov txheej txheem dermal.

Kev daws teeb meem:Thaum tsis tshua muaj ntau dua bupivacaine lossis Lidocaine rau txha caj qaum vim muaj ntau qhov kev txhawj xeeb thiab sijhawm txhawj xeeb, nwstauraug muab sib xyaw rau hauv cov kev daws teeb meem rau kev siv qhov no hauv qab kev cai tshwj xeeb.

● Txuas ntxiv txee - lub neej muaj sia nyob (khaws cia zoo):Lub anhydrous hmoov nws tus kheej, tiv thaiv los ntawm lub teeb, thiab oxygen nyob rau hauv nruj me ntsis cov kev daws teeb meem lossis cream tau raug rau hydrolysis thiab microbial kev loj hlob.

Tus nqi - ua tau zoo (feem ntau sib txawv):Rau cov tsev lag luam lossis cov kev coj ua uas xav tau cov kev xav tau loj ntawm cov kev txhawj xeeb uas tsis muaj kev lag luam ntau dua li kev yuav ntau dua li kev yuav khoom ua ntej ua ntej.

Tetracaine hmoov cov nqi hluav taws xob stems los ntawm nws cov potency thiab muaj peev xwm ua kom nws tus menyuam:

● Ophthalmology:Tustus qauv kubRau corneal antesthatesia thaum lub sij hawm tuonometry, lub cev txawv teb chaws lub cev, thiab cov txheej txheem kuaj mob me. COMPALEDED SULE {{{1} Siv Minims ua kom muaj zog thiab potency.

● otolaryngology (ENT):Kev tshuaj xyuas kev ua kom zoo siab nasal mucosa (ua ntej endoscopy, ntim), pharyngeal / tonsillal chaw, lossis kwj dej pob ntseg.

Rermatology & Yas phais:Kev tiv thaiv kab mob zoo nkauj hauv cov tshuaj pleev ib ce tshuaj loog / kua txiv ("blt"

● Cov UREVER:Kev ua kom loog ntawm cov urethal mucosa ua ntej catheterization, cystoscopy, lossis lwm yam khoom siv.

● Printology:Kev nyem siab rau cov hemorrhoids lossis fissures, lossis mucosal antesthesia ua ntej anoscopy / proctoscopy.

● Kev Tu Vaj Tse:Daim ntawv thov cov tshuaj pleev ntawm qhov ncauj mucosa ua ntej txhaj tshuaj lossis cov txheej txheem me (tab sis lidocaine feem ntau nyiam kev txhaj tshuaj).

● Cov kws kho tsiaj kho mob:Cov ntawv thov zoo sib xws (ocular, dermal, mucosal) txiav rau cov neeg mob tsiaj.

● Cov txhab kev saib xyuas:Tswj kev mob siab nyob rau hauv salficial Burns lossis mob rwj ntawm cov ntawv thov.

Cov Txheej Txheem Tshwj Xeeb:Compounded rau hauv cov ntsiab lus tshwj xeeb rau kev kuaj mob lossis kho cov hlab ntsha uas nws cov cim tshwj xeeb uas nws cov cim tshwj xeeb (lub sijhawm ntev) yog qhov zoo.

● Intrinsic potency:Tetracaine tseem muaj zog dua liidocaine lossis procaine (kwv yees li 10x lidocaine sab saum toj). Qhov no tso cai rau kev ua kom zoo ntawm cov tshuaj / ntau dua hauv cov qauv customized.

● Ceev xwm ceev (pleev):Ua tau cov tshuaj loog ua tiav tau sai sai, tshwj xeeb tshaj yog ntawm cov cwj mem mucous thiab lub pob zeb (pib li 30 feeb mus rau ocular siv).

● Ntev ntev ntev (piv rau lwm yam neeg estres / qee qhov chaw):Muaj kev txiav txim siab ntev dua propaine lossis chloroprocaine (esters) thiab feem ntau ntev dua lidocaine pleev. Cov kev cuam tshuam ntawm cov ntsiab lus muaj peev xwm nyob ntev li 15-30 feeb ntawm cov membous thiab mus txog 30-60 feeb lossis ntau dua ntawm cov ntaub ntawv dermal occlusion.

● Txheeb xyuas kev xav tau:Tso cai rau Compounding ntawm lub zog ua tau zoo, kev sib txuas (synergistic blends zoo li blt), thiab cov tshuaj, tshuaj tsuag) ua kom zoo rau cov txheej txheem anatomical, cov txheej txheem, thiab tus neeg mob siab.

● Txo cov chaw tsim hluav taws xob (tej zaum):Txhim kho cov kev ua haujlwm thiab cov ntawv thov tsom tuaj yeem txo cov tshuaj tag nrho piv rau kev siv ntau dua cov khoom muaj zog tsawg dua.

Qhov tseem ceeb, cov hmoov tetracaine yeej tsis tau thov ncaj qha rau cov ntaub so ntswg.Nws ib txwm muaj kev tshaj lij ua ke rau hauv lub ruaj khov, tsim nyog ua los tsim nyog nyob rau hauv cov kev mob xws li aseptic thaum tsim nyog.

● Cov kev tsim kom zoo nkauj dua (cov qauv kawg):

○ Iphalmic:0.25% rau 1.0% (feem ntau yog 0.5%) hauv cov tshuaj areterous.

○ Cov ntsiab lus (cov yeeb yaj kiab zoo):0.5% rau 2.0% hauv kev daws teeb meem, cov kua nplaum, lossis tshuaj pleev.

○ Dermal (occluded -} eg, blt creams):Feem ntau 2% rau 8% (feem ntau 4-6%), ua ke nrog lwm qhov kev ntsuas tshuaj loog thiab nkag mus rau lwm tus.

○ Invathecal (tsis tshua muaj, tshwj xeeb heev):Cov koob tshuaj yog tsawg heev (piv txwv li, 2-5 mg), xav kom muaj kev hloov kho ntau yam thiab cov kev hloov pauv ntawm cov kev hloov pauv ntau yam; tsis yog ib txwm siv.

Rosing cov ntsiab cai:

○ Qhov tsawg kawg nkaus koob tshuaj:Siv qhov qis qis tshaj plaws thiab ntim tsawg dua.

○ Thaj chaw thaj tsam thaj chaw:Koob correlates nrog thaj chaw tshuaj loog, tshwj xeeb tshaj yog qhov tseem ceeb rau cov ntawv qhia nto loj hauv qab occlusion (dermal).

Thov thov sijhawm:Lub sijhawm sib cuag tau cuam tshuam cuam tshuam thiab nqus (tshwj xeeb yog kev ua haujlwm hauv qab occlusion eccoclusion tsis siv, piv txwv li, 20-60 feeb max rau blert creams).

○ Tseem ceeb tsuag:Tej leeg vascular thaj chaw (cov plaub caug lub cev) nce kev phom sij hnyav.

Tshaj tawm cov kauj ruam tseem ceeb:

1.Txoj kev hnyav hnyav:Siv ntsuas ntsuas ntsuas ntsuas hauv kev tswj hwm ib puag ncig.

2.Ateptic txheej txheem:Yuav tsum tau rau kev npaj tsis muaj zog (ophthalmic, intrathecal, qee qhov muaj kev). Tsis -} stericals tseem yuav tsum muaj cov txheej txheem huv.

3.Solubilization:Dissolving nyob rau hauv cov kuab cua uas tsim nyog (dej huv, qab ntsev, hauv paus tshwj xeeb rau cov tshuaj pleev xim rau cov tshuaj / cream). PH kev hloov kho yuav tsum tau rau kev ruaj khov thiab xis nyob.

4.Tabilizers & Cov tshuaj txuag:Ntxiv cov tshuaj tua kab mob tshuaj tua kab mob (piv txwv li, sodium methatics) thiab antimicrobial cov tshuaj loog rau multiThtalmic) raws li cov qauv tsim thiab USP.

5.filtration (tsis huv):Rau cov niam txiv lossis cov kev daws teeb meem ophthalmic.

6.Playaging & labelling:Siv cov thawv uas tsim nyog (Amber vials rau lub teeb kev tiv thaiv, cov tub rog uas tsis muaj kab, ntawm {{{}}}}}}}}} kev qhia.

7.Thov kev kuaj mob & Bud tes haujlwm:Tom qab USP cov lus qhia raws cov qauv, cia, thiab tshuaj ntsuam xyuas kev ua tau zoo.

"Lub voj voog" voj voog ":Hauv chaw muag tshuaj, "kev voj voog" tsis yog tus qauv rau kev pleev tshuaj loog hauv zos zoo li Tetracaine. Nws qhov tseeb nyob hauv:

○ Rov qab - Daim ntawv thov zaus:Dictated los ntawm cov txheej txheem ntev thiab ntev ntawm cov nyhuv. Rau cov txheej txheem ntev, re6 {{{{{{{{{1} Daim ntawv thov yuav tau tom qab cov nyhuv} Cov nyhuv ris tsho hnav (piv txwv li 20-40 feeb kos rau ntawm qhov chaw / Tsim).

○ Lub voj voog metabolic:Raws li tus ester, tetracaine tau sai hydrolyzed nyob rau hauv lub ntshav thiab nplooj siab los ntawm psudocholinesterase rau hauv para {} i} i}}) thiab lwm cov metabolites. Qhov enzymatic puas yog nws lub voj voog metabolic "."

● Ib nrab - lub neej (tshem tawm ib nrab {} lub neej- t½):

    ○Tetracaine muaj aHeev luv luv comiminic tshem tawm ib nrab - lub neej, kwv yees yuav tau nyob hauv ntauvib nas this mus rau ob peb feeb (feem ntau <2 feeb)Cov. Qhov kev metabolism no yog vim nws cov qauv ester thiab txuag cov hydrolysis los ntawm pseudocholinesterase.

Classance Qhov Tseem Ceeb:Lub luv luv ib nrab - lub neej pab rau:

Txo cov kev pheej hmoo txaus ntshai (piv rau cov lus teb):Yog hais tias nqus, nws tau raug tshem sai.

Vam khom ntawm pseudocholinesterase:Cov neeg mob muaj caj ces caj dab pseudocolineteresase tsis muaj tshuaj tiv thaiv (lossis tau txais tsis muaj tshuaj, kab mob, lossis co toxins) yog nyob rau ntawmtseem ceeb nce kev pheej hmoo ntawm cov kab mob toxicity(Cns excitation / chewInures ua raws los ntawm kev nyuaj siab, plawv plab zom mov) los ntawm tetracaine, raws li kev ua haujlwm hydrolaines, li kev ua haujlwm thiab cov ntshav. Nov yog kev ntseeg cuav kev nyab xeeb.

◇ Txwv tsis pub siv hluav taws xob rau lub caij nyoog:Nws cov metabolism ceev rau ntev rau ntev - Lub zog hauv cheeb tsam ntawm ib qho kev txhaj tshuaj thiab tsis zoo li bupivacaine lossis ropivacaine.

Notion =} toxicity muaj kev pheej hmoo:High potency txhais tau tias yog qhov ntsuas nqaim. Meticulous compounding thiab koob tshuaj tsis yog tsis - sib yeem. Kev noj tshuaj dhau los yuav ua rau mob hnyav, lub neej - kev hem tsis zoo (cns thiab plawv plawv).

Ester ua txhua yam:Lub Paba metabolite yog ib qho paub ua ke. Tetracaine yog contraindicated nyob rau hauv cov neeg mob uas tau paub ester forthetic lossis paba ua xua. Hla - reactivity nrog rau lwm yam esters (procaine, benzocaine) yog ib qho.

Leudocholinesterase:Raws li saum toj no, ib tug loj contrainudication lossis kev ceev faj txog kev ceev faj.

● Mucous membrane & Occluded Dermal nqus:Qhov tseem ceeb ua kom haum tuaj yeem tshwm sim tuaj yeem tshwm sim, tshwj xeeb tshaj yog nrog cov khoom siab muaj ntau, thaj chaw loj, lossis daim tawv nqaij / mucosa. Nruj me ntsis rau qhov kev pom zoo tshaj plaws koob tshuaj thiab cov sijhawm ntawv thov (tshwj xeeb rau blt cream) yog qhov tseem ceeb.

● Methemoglobinemia pheej hmoo (theoretical):Thaum tsis tshua muaj feem cuam tshuam ntau dua benzocaine lossis prilocaine, tus neeg kab plaub metaboliteyuavPab txhawb rau methemoglobinemia, tshwj xeeb hauv cov neeg muaj kev phom sij lossis cov koob tshuaj ntau.

● Cov lus qhia txog ophthalmic:Tuaj yeem ua rau muaj kev hloov pauv, corneal epithelial lom zem nrog lub caij nyoog / rov siv dua, thiab ncua kev puas tsuaj kho kom zoo. Kev muaj menyuam tsis muaj menyuam.

Ring Kev Tuav Pov Tseg:Cov hmoov nqus tau pa thiab tawv nqaij tiv thaiv kev pheej hmoo thaum sib sau ua ke. Tsim nyog Ppe (hnab looj tes, npog ntsej muag, kev tiv thaiv qhov muag) thiab engineering tswv yim) yog qhov tseem ceeb.

Kev Lag Luam Npe	Tetracaine, Amethocaine, Pontocaine, Ametop, Dicaine
Cas	94-24-6
Tus hniav loj	264.37
Mf	C15H24N2O2
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	Dawb crystalline hmoov

 

 

Kev xav tau, thov hu rau peb

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Tetracaine hmoov tsis yog cov tshuaj xws li; Nws yog tus muaj zog, ntau yam tseem ceeb tseem ceeb cov khoom siv rau cov khoom siv tes ua daj hauv zos tshuaj loog anesthetic daws. Nws tus nqi nyob hauv lub cev muaj peev xwm ua kom nws txoj kev ua yeeb yam kom zoo rau kev ua kom mob siab rau cov txheej txheem dermal nyob rau hauv cov tshuaj loog. Txawm li cas los xij, lub hwj chim no xav tau kev hwm. Nws cov metabolism estre, tsis pub muaj peev xwm, thiab tseem pheej yig ntawm kev txawj ntse thiab cov txheej txheem ua tiav txhua kauj ruam. Siv kev paub tshwj xeeb thiab meej, tetracaine hmoov tseem muaj qhov tsis tseem ceeb, thev naus laus zis rau archamentarium rau kev ua tiav cov tshuaj loog hauv cheeb tsam. Nws lub luag haujlwm yog khov kho rooted nyob rau hauv cov kos duab thiab kev tshawb fawb ntawm cov kws tshuaj sib txuas, Bridging cov kev sib txawv ntawm cov qauv kev saib xyuas cov cai thiab kev saib xyuas tus neeg mob.

Cim npe nrov: Tetracaine hmoov rau cov tshuaj loog hauv cheeb tsam ib cheeb tsam: 94-24-6, Tuam Tshoj tetracaine hmoov rau cov tshuaj loog hauv cheeb tsam cas: 94-24-6erse, Hoobkas