Testosterone Undecanoate
Testosterone undecanoate, muag raws li lub npe Andriol thiab Aveed ntawm lwm tus, yog ib qho androgen thiab anabolic steroid (AAS) .Nws tuaj yeem txhawb kev loj hlob ntawm txiv neej, txiv neej theem nrab kev sib deev yam ntxwv thiab kev loj hlob ntawm testis thiab accessory gonad lug. Txhawb nqa protein synthesis thiab txo qhov kev puas tsuaj, txhim khu kev tiv thaiv kab mob, txhawb cov pob txha loj hlob. Txhawb nqa erythropoiesis, tawm tswv yim inhibition ntawm gonadotropin secretion, inhibition ntawm estrogen secretion.
Khoom npe: Testosterone Undecanoate
Hom Lub Npe (yog tias tsim nyog): [Lub Npe Lub Npe]
Cov khoom xyaw nquag: Testosterone Undecanoate
Lub zog: [piv txwv li, 40 mg, 1000 mg, thiab lwm yam]
Kev nthuav qhia: [piv txwv li, Mos gel capsules]
Testosterone Undecanoate yog ib hom hluavtaws ntawm cov txiv neej pw ua ke hormone testosterone. Nws yog formulated raws li ib tug mos gel capsule rau lub qhov ncauj tswj. Txhua lub capsule muaj ib qho tshwj xeeb ntawm testosterone undecanoate, uas yog ib daim ntawv esterified ntawm testosterone.
Cov lus qhia:
Testosterone Undecanoate yog qhia rau cov tshuaj hloov tshuaj hormones (HRT) nyob rau hauv cov txiv neej laus nrog hypogonadism, ib tug mob tshwm sim los ntawm tsawg theem ntawm endogenous testosterone ntau lawm. Nws yog siv los ntxiv lub cev nrog testosterone thiab txo cov tsos mob txuam nrog testosterone deficiency.
yam ntxwv nta
Testosterone undecanoate yog ib daim ntawv hloov kho ntawm testosterone nyob rau hauv uas ib tug carboxylate (undecanoic acid) tau txuas mus rau 17-beta hydroxyl pawg. Daim ntawv esterified ntawm testosterone yog tsawg dua polar tshaj li dawb testosterone thiab yog absorbed qeeb dua nyob rau hauv qhov chaw txhaj tshuaj. Ib zaug nyob rau hauv cov ntshav, cov ester raug tshem tawm los tsim dawb (active) testosterone. Daim ntawv esterified ntawm testosterone yog tsim los kom ntev lub qhov rais ntawm kev kho mob tom qab kev tswj hwm, tso cai rau kev txhaj tshuaj tsawg dua piv rau kev txhaj tshuaj dawb (tsis yog-esterified) steroids. Nebido yog tsim los tswj cov qib physiological ntawm testosterone mus txog 14 lub lis piam tom qab txhaj tshuaj.
qhia
1) Thawj lossis theem nrab testicular hypofunction;
2) Kev cai lij choj ncua kev puberty rau cov tub;
3) Palliative kho mob cancer mis metastasis;
4) Adjuvant kho rau aplastic anemia;
5) Ib nrab androgen deficiency syndrome nyob rau hauv nruab nrab-hnub nyoog thiab cov neeg laus;
6) Rheumatoid mob caj dab.
doasg ua
Nws yuav tsum tau siv raws li kev taw qhia ntawm tus kws tshaj lij. Qhov pib koob tshuaj yog 120-160mg (3-4 capsules) ib hnub, thiab tom qab ob lub lis piam ntawm cov tshuaj, cov koob tshuaj txhua hnub tau khaws cia ntawm 40-120mg (1-3 capsules). Ob zaug thaum sawv ntxov thiab yav tsaus ntuj, hais lus tom qab noj mov. Yog tias koj noj cov tshuaj ntsiav ib hnub twg, noj 1 ntsiav tshuaj ntxiv thaum sawv ntxov, lossis ua raws li tus kws kho mob cov lus qhia.
Pharmacokinetics
Tom qab kev tswj hwm ntawm qhov ncauj, cov tshuaj tau nqus rau hauv cov hlab ntsha lymphatic ntawm txoj hnyuv me hauv daim ntawv ntawm chylomicrons, nkag mus rau hauv cov hlab ntsha hauv cov hlab ntsha, thiab tso tawm testosterone tom qab ester bond cleavage. Daim ntawv no ntawm kev nqus tsis txhob ua rau lub siab ua ntej dhau los thiab hepatotoxicity. Lub sijhawm siab tshaj plaws ntawm cov ntshav testosterone tom qab kev tswj hwm qhov ncauj muaj qhov sib txawv ntawm tus kheej, nrog qhov nruab nrab ntawm li 4 teev. Tom qab kev tswj hwm tas mus li, cov qib testosterone hauv cov ntshav maj mam nce thiab nce mus txog lub xeev khov kho tom qab 2 mus rau 3 lub lis piam; Tom qab ib qho kev txhaj tshuaj intramuscular ib zaug, lub sijhawm ntawm cov tshuaj testosterone siab tshaj plaws yog li 7 hnub, thiab rov qab mus rau qib ua ntej txhaj tshuaj intramuscular tom qab 21 hnub. Cov khoom no yog cov tshuaj lipophilic, tom qab kev tswj hwm qhov ncauj, nws tau nqus los ntawm cov kab mob lymphatic ua ke nrog cov lipids, nrog rau cov neeg sib txawv loj, tmax yog 1 mus rau 8 teev, thiab qhov nruab nrab yog 4 teev. Tshaj tawm los ntawm cov zis, tag nrho cov zis hauv 1 lub lis piam tom qab noj cov tshuaj yog 45 feem pua rau 48 feem pua, thiab 40 feem pua ntawm cov tshuaj absorbed hauv 24 teev tshwm hauv cov zis.
Cov ntaub ntawv kho mob
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Cov npe lag luam |
Qhov ncauj: Kyzatrex, Andriol, Jatenzo, thiab lwm yam IM: Aved, Nebido |
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Lwm Lub Npe |
TU; Testosterone undecylate; Testosterone 17 -undecanoate; ORG-538; CLR -610 |
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CAS |
5949-44-0 |
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Molar loj |
456.711 |
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MF |
C30H48O3 |
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Purity |
Tshaj 98 feem pua |
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Yam khoom |
Dawb crystalline hmoov |
Txhua yam kev xav tau, thov hu rau peb
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Cim npe nrov: Tuam Tshoj Testosterone Undecanoate manufacturers, lwm tus neeg, Hoobkas
