Lidocaine Cov Khoom Siv Raw Khoom Siv Rau Cov Tshuaj Ntsuam Xyuas Hauv Cheeb Tsam: 137-58-6

Dab tsi yog lidocaine cov khoom siv raw hmoov?

Lidocaine cov khoom siv cov khoom siv yog qhov ua kom huv, crystalline cov tshuaj sib xyaw ua ke ntawm cov tshuaj sib xyaw ua ke 2- n- (2,6-dimethylpheny. Nws cov tshuaj Abstract tshuaj (CAS) yog 137-58-6. Raws li ib qho API, nws yog tsim thiab muab nyob rau hauv nruj kev kev tsim kho nruj (GMP) cov lus qhia kom ntseeg tau kev coj dawb huv, feem ntau tshaj 99.5%. Cov hmoov no tsis yog npaj rau coj ncaj qha rau tib neeg lossis tsiaj siv; Nws yog kev lag luam nruab nrab hauv nruab nrab rau cov tshuaj hauv paus. Nws tus nqi nyob hauv nws cov versatility, ua haujlwm raws li cov khoom noj tseem ceeb uas cov khoom siv hydrochlorical, suav nrog cov tuam txhab kev siv nyiaj, tshuaj ntsuab, tshuaj tsuag, thiab kev hloov pauv.

Cov hmoov nplej nyoos muaj cov khoom siv dag lub cev uas txhais tau nws txoj kev tuav, kev ruaj khov, thiab tsim cov peev xwm:

Lub cev daim ntawv lub cev:Nws feem ntau pom tias yog dawb, tsw ntxhiab, crystalline hmoov. The crystal morphology can vary (polymorphism), which can influence its dissolution rate and stability, a critical factor for manufacturers.

Liphibilicity:Hauv nws lub hauv paus daim ntawv, Lidocaine tsis zoo soluble hauv dej tab sis soluble heev hauv lipids (cov rog). Cov cuab yeej Intrinsem no yog qhov tseem ceeb rau nws txoj haujlwm, raws li nws tso cai rau cov molecule kom tiav diffuse los ntawm kev tawm ntawm cov hlab ntsha juav. Rau aqueque txoj kev txhaj tshuaj, nws hloov dua siab tshiab rau nws cov dej - soloole hydrochloride ntsev (Lidocaine HCl).

● Kev ruaj khov:Cov hmoov yog ruaj khov nyob rau hauv cov neeg mob pom zoo {{}} {} {1} {{1} {{1} Lub teeb thiab noo noo nyob rau hauv nruj nroos ntim. Nws yog qhov ntxim rau kev cuam tshuam rau kev cuam tshuam thaum lub sijhawm ntev los ua kom sov, lub teeb, lossis qib rau.

● Melting point:Nws muaj txhais tau cov ntsiab lus melting ntau (kwv yees li 66-69℃rau hauv paus daim ntawv), uas yog tus cim tseem ceeb thiab kev tswj hwm zoo parameter rau cov khoom siv raw khoom thiab tus txais.

Profile Vocity Profile:Kev ntsuas kev ntsuas nruj (HPLC, GC) paub txog qhov tsis muaj kev phom sij thiab cov txheej txheem kev nyab xeeb los ntawm kev nyab xeeb thiab ua tau zoo ntawm cov khoom siv tshuaj kawg.

Thaum ua kev txhaj tshuaj, cov khoom siv raw hloov pauv rau qhov dav dav ntawm cov ntawv thov kev kho mob ib zaug tau tsim:

1.Txhua tshuaj loog:Thawj qhov kev siv. Cov hmoov tau hloov pauv mus rau lidocaine hydrocaine hydrocainide thiab yaj hauv cov tshuaj loog rau infiltration), cov hlab ntaws (phiaj xwm tshwj xeeb lossis txha caj qaum.

2.Txoj kev tsim qauv:Incorporated rau cream, gels, tshuaj pleev, thiab tshuaj pleev} lorocaine tov ua ntej cov txheej txheem, kom kho mob tshav ntuj, lossis rau kab tom.

3.mucosal daim ntaub ntawv:Tsim los rau hauv cov kev daws teeb meem rau qhov ncauj, ligal tshuaj loog rau kev pab txhawb cov txheej txheem endoscopic, interubation, lossis los txhawm rau txhawm rau ua kom lub gag reflex.

4.Qhov kev daws teeb meem:Siv rau hauv qhov muag poob rau corneal antesthatesia thaum lub sijhawm phais lossis kev phais ncua.

5.Transdermal patches:Cov hmoov tau ua rau engesive rau hauv cov nplaum ua kom zoo nkauj (piv txwv li los xa cov tawv nqaij kom maj mam los ntawm kev mob siab rau cov nqaij mos los ntawm kev mob hlwb zoo li post- herpetic neuralgia.

6.istiarhythmic siv:Hauv nws daim foos uas tau txais, nws yog siv rau hauv lub neej muaj xwm ceev los kho lub neej {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}

Cov thoob plaws kev saws me nyuam ntawm lidocaine raws li kev tshuaj loog hauv zos ntawm kev xaiv rau xyoo lawm tau vim muaj zog sib xyaw ntawm cov txiaj ntsig ntawm cov qauv tshuaj:

● Rov qab pib ua haujlwm:Nws qhov ntsuas Lipophilicity tso cai rau Swift doltusion rau hauv qab haus huv, ua rau lub caij nrawm nrawm ntawm sodium raws thiab pib nrawm ntawm loog.

● Muaj lub sijhawm ntev heev:Nws muab cov sijhawm nruab nrab ntawm qhov kev txiav txim (feem ntau 1-2 teev), uas yog qhov zoo tagnrho rau ntau cov kev phais mob thiab txheej txheem kev siv. Qhov no tuaj yeem ntev nrog kev sib ntxiv ntawm lub vasoconstrictor zoo li epinephrine.

● Cov pov thawj kev nyab xeeb kev nyab xeeb:Nrog kaum tawm ntawm kev siv kho mob, nws cov tshuaj lom neeg tshuaj thiab tshuaj lom yog zoo {{0} nkag siab, ua rau tus neeg sawv cev muaj kev ntseeg siab thiab ntseeg siab.

● Versatility:Raws li muaj pov thawj los ntawm nws cov ntawv thov, nws cov tshuaj lom neeg pub nws tsim tawm mus rau yuav luag txhua qhov kev xa khoom, ua rau nws tsis tseem ceeb hla kev kho mob tshwj xeeb.

Tus nqi - ua tau zoo:Cov synthesis ntawm Lidocaine tau zoo - tsim thiab txuag tau cov khoom siv raw, uas txhais tau los nqis peev rau qhov kawg {}}} cov khoom rau cov khoom siv kho mob.

Qhov tseem ceeb, tsis muaj ib qho "noj tshuaj" rau cov khoom siv raw khoom.Nws yog ib qho khoom noj khoom haus. Cov koob tshuaj raug txiav txim siab thaum lub sijhawm tsim khoom siv tshuaj lag luam thiab yog tshwj xeeb rau cov khoom kawg, cov qauv tsim qauv, thiab txheej txheem kev tswj hwm.

Cov kev daws teeb meem:Feem ntau yog los ntawm 0.5% mus rau 2% siab. Qhov kev pom zoo tshaj plaws cov koob tshuaj yuav raug txhais nruj me ntsis (piv txwv li, 4.5 mg / kg tsis muaj epinephrine, nce mus txog 7 mg / kg nrog epinephrine) kom tsis txhob muaj kev lom zem.

● Cov tshuaj pleev cov yeeb yaj kiab / gels:Feem ntau yog ntawm 2% mus rau 5%.

● Transdermal patches:Muab cov tshuaj tshwj xeeb ntawm ib thaj (piv txwv li, 700 mg ib thaj rau lidoderm®, xa ~ 10 mg / teev).

Lub luag haujlwm ntawm cov chaw tsim khoom siv Raw yog los muab cov hmoov sib xws, cov hmoov ntshiab li ntawd tuaj yeem yog thiab ntseeg tau cov tshuaj zoo hauv lawv cov khoom.

Lub "voj voog" ntawm Lidocaine hauv lub cev hais txog nws cov kev taug kev muag khoom, uas pib ib zaug cov khoom lag luam raug tswj hwm.

1.Qhov:Tus nqi ntawm kev nqus tau zoo heev rau txoj kev ntawm kev tswj hwm thiab kev tshwm sim ntawm lub xaib. Cov ntaub ntawv thov cov ntsiab lus ua rau qeeb nqus pa, thaum txhaj rau hauv cov vascular cov tshuaj tshwm sim hauv cov hlab ntshav.

2.Distribution:Lidocaine tau faib dav thoob plaws hauv lub cev. Nws tau yooj yim hla cov ntshav -}} lub hlwb thiab cov txheej txheem placental. Nws muaj lub zog ntim ntawm kev faib tawm, lub ntsiab lus nws tsis yog ncaj ncees rau cov hlab ntshav tab sis faib ua cov ntaub so ntswg.

3.Metabolism:Nov yog ib qib tseem ceeb. Lidocaine undergoes hatensive thawj {{}}}}}}}}}}}}}}} me me los ntawm cytochrome P450 Enzyme System (CYP1A2). It is metabolized into active metabolites like monoethylglycinexylidide (MEGX) and glycinexylidide (GX), which contribute to both efficacy and toxicity.

4.elimination:Cov metabolites thiab ib qho feem me me ntawm cov tshuaj tsis hloov pauv tau tawm ntawm ob lub raum mus rau cov zis.

Lub sijhawm tshem tawm ib nrab - lub neej ntawm Lidocaine- Lub sijhawm nws siv rau ib nrab- yog kwv yees li1.5 txog 2 teevHauv cov neeg laus uas muaj hepatic thiab mob plawv ua haujlwm. Qhov ntsuas no yog qhov tseem ceeb rau kev nkag siab txog kev siv nyiaj sib nrug thiab cov peev txheej kev hnav tsoos. Ob peb yam tuaj yeem hloov kho nws ib nrab - lub neej:

● Daim siab ua haujlwm:Hepatic puas los yog txo lub siab ntshav ntws (piv txwv li, los ntawm lub plawv tsis ua haujlwm) muaj peev xwm ua kom ntev ntev li ib nrab {2} Lub neej, nce txoj kev pheej hmoo ntawm kev lom zem.

Ultrasonic Tshuaj sib cuam tshuam:Kev saib xyuas cov tshuaj uas cuam tshuam Cyp3A4 enzymes (piv txwv li beta- blockers xws li ketoconazole) tuaj yeem qeeb ib nrab- lub neej.

● Hnub nyoog:Neonates tsis muaj lub siab mob ntsws ua kom zoo nkauj, thiab cov neeg laus yuav tau txo lub siab ua haujlwm, ob qho tib si rau ib nrab ntev- lub neej.

Nyob rau hauv cov ntsiab lus ntawm cov khoom siv raw, PTC Transcends "Pre -}} Nrhiav mus sib hais" thiab yog qhov zoo tshaj plaws raws li covKev Tshaj Lij Tshaj Lij Cov Lus Qhiatswj hwm nws lub neej.

● Kev tswj xyuas:Cov hmoov yuav tsum tau raws li cov qauv tswj hwm (piv txwv li, USP, ph. EUR., JP) rau tus kheej, kev ua yeeb yam, thiab impurities. Qhov no suav nrog daim ntawv pov thawj ntawm kev tsom xam (COA) cov ntaub ntawv.

Muab cov khoom siv khoom:Sourcing yuav tsum yog los ntawm kev pom zoo, GMP {{{0} Raws li cov khoom lag luam, thiab ua kom muaj kev sib raug zoo, thiab paub meej tias muaj kev phom sij ntawm kev ua kom zoo.

Kev Lag Luam Npe	Lidocaine, xylocaine, ztlido, lignocaine
Cas	137-58-6
Tus hniav loj	234.343
Cov lus ntawm ib txoj kab ke	C14H22N2O
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	Dawb crystalline hmoov

 

 

Kev xav tau, thov hu rau peb

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Lidocaine cov khoom siv raw hmoov yog deb tshaj li cov tshuaj uas yooj yim; Nws yog cov ncej pillar uas niaj hnub ua yeeb yaj kiab anesthesia niaj hnub. Nws tshwj xeeb cov khoom siv dag muab cov khoom siv nws tsis muaj txiaj ntsig, ua kom nws cov qauv kho mob sib txawv. Nws lub siab {- Cov txiaj ntsig tau zoo, thiab kev nyab xeeb profile, catent nws cov xwm txheej uas yog cov khoom siv irrecervaable hauv tshuaj. Kev taug kev los ntawm ib qho hmoov crystalline rau lub neej - kev txhim kho kev kho mob yog ib qho kev tshawb fawb ntawm cov tshuaj uas muaj txiaj ntsig ntawm cov txiaj ntsig zoo tshaj plaws.

Cim npe nrov: Lidocaine Cov Khoom Siv Raw Rau Cov Tshuaj Ntsuam Xyuas Hauv Cheeb Tsam: 137-58-6, Tuam Tshoj Lidocaine Cov Khoom Siv Hauv Cheeb Tsam: 137-58-6 Cov Chaw Tsim Tshuaj, Chaw Tsim Tshuaj, Chaw Tsim Tshuaj