Dutasteride (Avodart) CAS: 164656-23-9

   Dutasteride pab tiv thaiv cov plaub hau li cas?

"Dutasteride yog ib qho tshuaj uas thaiv cov enzyme hu ua 5-alpha reductase (5-AR)," piav qhia Dr. Simon Pimstone, tus tsim, thiab tus thawj coj, ntawm XYON Health Inc. "Cov enzyme no yog lub luag haujlwm rau kev tsim cov dihydrotestosterone (lossis DHT), uas yog androgen hormone uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm prostate thiab txiv neej qauv plaub hau poob.

Dutasteride feem ntau siv nyob rau hauv cov xwm txheej uas cov plaub hau poob yog qhov dav lossis tsis teb rau lwm txoj kev kho mob hu ua finasteride.

Ob qho kev kho mob no thaiv 5-AR, txawm li cas los xij, Pimstone taw qhia tias dutasteride inhibits ob hom enzyme hu ua isoforms I thiab II, thaum finasteride tsuas yog ua rau isoform II.

Finasteride tseem tsuas thaiv txog 70% ntawm kev hloov pauv ntawm testosterone rau hauv DHT. Dutasteride tuaj yeem thaiv ntau dua 90% Trusted Source.

Noj dutasteride qhov ncauj ua haujlwm los ntawm kev txwv tsis pub hloov pauv ntawm testosterone rau DHT hauv lub cev kom DHT tsis muaj sijhawm mus txog cov hauv paus plaub hau.

Thaum siv tshuaj pleev ib ce, nws ua haujlwm los ntawm kev tso tseg DHT hloov dua siab tshiab hauv cov hauv paus plaub hau.

Yog li, dutasteride zoo npaum li cas thaum siv los ua kev kho mob rau cov plaub hau poob?

Thaum muab piv rau finasteride, Pimstone hais tias dutasteride yog qhov muaj zog ntau dua inhibitor ntawm 5-AR enzyme thiab li no muaj zog ntau dua hauv kev txo qis DHT.

Tshwj xeeb, nws hais tias thaum siv cov tshuaj pleev ib ce, dutasteride tuaj yeem muaj cov txiaj ntsig zoo hauv kev kho mob raws li nws xa cov tshuaj ntau dua rau lub hom phiaj ntawm cov plaub hau follicle.

"Ib tug xov tooj ntawm kev tswj kom zoo thiab kev soj ntsuam soj ntsuam kev tshawb fawb tau tam sim no qhia meej cov txiaj ntsig ntawm dutasteride tshaj finasteride," Pimstone surmises. "Cov txiaj ntsig kho mob ntawm dutasteride tshwm sim los ntawm nws cov txiaj ntsig zoo ntawm 5-AR enzyme thiab DHT."

Hauv ib qho meta-analysisTrusted Source tau ua nyob rau xyoo 2019, dutasteride tau pom qhov nce ntxiv ntawm tag nrho cov plaub hau suav piv nrog finasteride.

Lub caij no, cov txiaj ntsig ntawm kev tshawb nrhiav cov placebo-tswj cov kev ntseeg siab ntawm dutasteride piv rau finasteride, pom tias yav dhau los tau ua haujlwm zoo dua hauv kev nce lub hom phiaj ntawm cov plaub hau suav.

Thaum muaj qee qhov kev tshawb fawb txhawb nqa cov txiaj ntsig ntawm dutasteride rau cov plaub hau poob, nws yuav yog qhov zoo tshaj plaws los tswj koj qhov kev cia siab.

Siv dutasteride tuaj yeem yog ib qho cuab yeej zoo rau kev txwv cov plaub hau, tab sis cov kws tshaj lij hais kom nco ntsoov tias nws yuav tsis loj hlob plaub hau.

Txawm li cas los xij, muaj kev sib txuas ntawm finasteride thiab minoxidil uas tau pom tias yog kev kho mob kom tsis txhob muaj plaub hau poob thiab txhawb cov plaub hau kev loj hlob tib lub sijhawm.

Raws li nrog rau txhua yam tshuaj, tshwj xeeb tshaj yog kev kho mob off-label, muaj kev pheej hmoo thiab kev phiv los xav txog.

Nws tseem ceeb heev uas yuav tsum nco ntsoov tias dutasteride tsis yog FDA pom zoo raws li kev kho plaub hau yog li koj yuav tsum tau siv kev ceev faj ntxiv yog siv nws rau lub hom phiaj no.

Qee qhov kev mob tshwm sim muaj xws li tawv nqaij thiab tawv nqaij khaus, hws txias, thiab kiv taub hau.

"Qee zaum, koj tuaj yeem ntsib kev nyuaj siab, mob hauv siab, o, kev sib deev tsis zoo, thiab xav tua tus kheej," Abdullah hais.

Txawm li cas los xij, Pimstone ntseeg hais tias cov tshuaj pleev ib ce - muab cov khoom xyaw siv nyob rau hauv ntau qhov chaw uas lawv paub tias muaj kev nyab xeeb - yuav tsum muaj kev nyab xeeb siv, "raws li cov ntaub ntawv tshuaj pleev ib ce feem ntau xa cov dutasteride tsawg dua rau hauv cov kab mob ntau dua li cov ntawv hauv qhov ncauj."

Nws kuj tau sau tseg tias qhov ncauj thiab tshuaj pleev xim dutasteride rau txiv neej qauv plaub hau poob tau kawm kho mob rau ntau xyoo.

"Nrog rau qhov kev kho mob dav dav no, peb tsis paub txog qhov tsis zoo tshwm sim uas tau hais txog kev pheej hmoo tseem ceeb nrog cov qauv ntawm qhov ncauj," nws xaus lus.

Txawm hais tias koj txiav txim siab siv dutasteride los yog tsis, Pimstone hais tias ib qho tseem ceeb tshaj plaws thaum nws los tiv thaiv cov plaub hau yog kho nws thaum ntxov.

"Feem ntau cov txiv neej xav tau ua ntej ntawm lawv cov plaub hau poob vim tias kev cuam tshuam ntxov thiab kev kho mob ntxov yuav tso cai rau cov txiaj ntsig zoo tshaj plaws," nws piav qhia.

"Yog tias muaj kev pheej hmoo rau cov plaub hau poob siab, lossis yog tias koj pom tias thinning (nrog rau thaj chaw uas koj feem ntau tsis pom zoo li lub kaus mom lossis saum koj lub taub hau), nws tsim nyog tham nrog kws kho mob txog cov kev xaiv," nws ntxiv.

Dr. Michele Green, tus kws tshaj lij kws kho hniav uas muaj ntawv pov thawj tshuaj pleev ib ce, hais tias nws pom zoo rau kev kho mob hu ua HydraFacial Keravive yog ib qho kev xaiv zoo rau kev noj qab haus huv ntawm tawv taub hau.

"Keravive kev kho mob siv cov txheej txheem peb-kauj ruam siv patented vortex thev naus laus zis los ntxuav thiab tshem tawm, txo cov flakiness, khaus, thiab khaus, thiab noj thiab moisturize ntawm tawv taub hau," nws hais. Nws tuaj yeem ua tiav txhua hli.

Ntsuab hais tias ob yam tshuaj tseem ceeb uas tam sim no tau pom zoo los ntawm FDA rau kev kho cov plaub hau yog finasteride thiab minoxidil. Finasteride, raws li tau hais dhau los, zoo ib yam li dutasteride. Minoxidil, ntawm qhov tod tes, ua haujlwm los ntawm kev rov ua kom cov plaub hau tsis muaj zog thiab elongating theem kev loj hlob ntawm cov plaub hau kev loj hlob.

"Muaj tshuaj tsawg minoxidil yog ib qho kev nyab xeeb thiab zoo cov plaub hau kev kho mob uas muaj zog cov hauv paus plaub hau thiab txhawb cov plaub hau tuav thiab kev loj hlob," hais tias Green.

Qee zaum, cov tshuaj hu ua spironolactone kuj tsim nyog. "Spironolactone yog ib qho tshuaj tiv thaiv androgen qhov ncauj uas tswj cov tshuaj hormones thiab tshwj xeeb tshaj yog pab tau rau cov poj niam cov neeg mob nrog PCOS," nws sau tseg. Nws pab txoj kev loj hlob ntawm cov plaub hau vim tias nws tuaj yeem txo qis cov txiv neej cov tshuaj hormones.

"Kev kho cov tshuaj hormones hloov pauv tuaj yeem yog ib qho kev xaiv rau cov neeg uas muaj cov plaub hau poob vim yog poj niam cev xeeb tub, PCOS, lossis hormonal irregularities," nws hais ntxiv.

Thaum kawg, Ntsuab taw qhia rau platelet-nplua nuj plasma (PRP) raws li txoj hauv kev uas tsis yog phais rau ob leeg txiv neej thiab poj niam-cov qauv plaub hau poob.

Platelet-nplua nuj plasma muaj cov yam ntxwv loj hlob uas tuaj yeem ua rau cov kab mob dermal papilla hauv cov hauv paus plaub hau, nws piav qhia. Cov platelets kuj muaj cov proteins uas txhawb cov nqaij mos zoo thiab rov tsim dua tshiab hauv cov hauv paus plaub hau tsis muaj zog.

"Hauv luv luv," nws hais tias, "PRP tswj kev noj qab haus huv ntawm cov hauv paus plaub hau, txhim kho cov ntshav mus rau thaj tsam thiab txhawb cov hlwb rov qab."

Kuj tseem muaj lwm txoj hauv kev uas cov kev tshawb fawb qhia tias yuav tiv thaiv cov plaub hau poob thiab, qee zaum, txhawb cov plaub hau kev loj hlob.

Txawm li cas los xij, cov no feem ntau qeeb qeeb.

Cov khoom siv plaub hau uas muaj cov roj tseem ceeb ntawm peppermint, rosemary, thiab lavender kuj tseem tuaj yeem pab txhawb cov hauv paus plaub hau.

Rau qee tus neeg txawm li cas los xij, cov kev daws teeb meem no tsuas yog tsis txaus.

Qhov xwm zoo yog, thaum nws los txog rau cov plaub hau poob, dutasteride tau pom tias muaj txiaj ntsig zoo hauv kev kho mob, feem ntau muaj kev nyab xeeb rau kev siv, thiab tam sim no siv tau ntau dua li qub.

Cov npe lag luam	Avodart, lwm tus; Combodart, Duodart (nrog tamsulosin), GG-745; GI-198745; GI-198745X; N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-aza-5 -androst-1-ene-17 -carboxamide
CAS	164656-23-9
Molar loj	528.539
MF	C27H30F6N2O2
Purity	Tshaj 98%
Yam khoom	Dawb crystalline hmoov

 

 

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Txheej txheem cej luam thiab Mechanism of Action

Dutasteride yog ib qho tshuaj feem ntau siv los kho benign prostatic hyperplasia (BPH), ib qho mob uas tshwm sim los ntawm kev loj hlob ntawm cov qog prostate. Nws belongs rau ib chav kawm ntawm cov tshuaj hu ua 5-alpha-reductase inhibitors. Dutasteride ua haujlwm los ntawm inhibiting enzyme 5-alpha-reductase, uas hloov testosterone rau hauv dihydrotestosterone (DHT). DHT yog ib qho muaj zog androgen uas ua lub luag haujlwm tseem ceeb hauv kev loj hlob thiab kev loj hlob ntawm prostate. Los ntawm kev txo qis ntawm DHT, dutasteride pab txo qis prostate, txo cov tsos mob ntawm cov zis, thiab txhim kho cov zis.

Kev siv tshuaj kho mob

Dutasteride feem ntau yog tshuaj rau cov txiv neej uas muaj cov tsos mob BPH. Cov tsos mob ntawm BPH suav nrog nyuaj pib tso zis, tsis muaj zog, thiab tso zis ntau zaus, tshwj xeeb tshaj yog thaum hmo ntuj. Los ntawm kev txo cov prostate loj, dutasteride pab txo cov tsos mob no thiab txo qhov kev pheej hmoo ntawm kev mob urinary retention thiab xav tau kev phais. Ntxiv nrog rau nws cov kev siv hauv BPH, dutasteride tau tshawb xyuas rau nws lub peev xwm hauv kev kho cov txiv neej qauv baldness, muab nws cov txheej txheem ntawm kev txo DHT, ib qho tshuaj hormone kuj cuam tshuam rau cov plaub hau poob. Txawm li cas los xij, nws tsis raug tso cai rau kev siv no hauv ntau thaj tsam thiab yuav tsum tau coj mus rau hauv kev saib xyuas kev kho mob nkaus xwb rau lub hom phiaj off-label.

Cov teebmeem thiab kev xav

Thaum dutasteride zoo hauv kev tswj cov tsos mob ntawm BPH, nws tuaj yeem muaj kev phiv. Cov teebmeem tshwm sim muaj xws li txo libido, erectile kawg, thiab ejaculation disorders, uas muaj feem xyuam rau nws cov tshuaj hormonal. Qee tus txiv neej kuj yuav muaj kev sib deev ntawm lub mis lossis loj. Qhov tseem ceeb, vim nws cov teebmeem ntawm cov tshuaj hormones, dutasteride tsis pom zoo siv rau cov poj niam lossis menyuam yaus. Tsis tas li ntawd, nws tuaj yeem cuam tshuam nrog kev kuaj mob prostate-specific antigen (PSA), tus cim siv los tshuaj xyuas mob qog noj ntshav prostate, muaj peev xwm npog qhov muaj tus kab mob.

 

 

 

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