Dapoxetine kho rau kev ntxov Ejaculation CAS: 129938-20-1
Ejaculation Ejaculation (PE) yog ib qho kev sib daj sib deev, tus cwj pwm uas tsis muaj txiaj ntsig, PE tau hais txog kev sib deev sai sai (SSRI), tshwm sim hauv xyoo 2009 ua cov tshuaj uas pom zoo tshwj xeeb rau tus pe hawm, thiab kev saib xyuas tshiab, muab cov kev tshawb tshuaj tshiab los ntawm cov ntsiab lus tshiab {}}
Dapoxetine yog dab tsi?
Dapoxetine yog SSRI txawv tsim rau kev siv rau hauv PE. Lub neej tsis zoo li qub rau kev siv rau cov xwm txheej tsis zoo txhua hnub) Johnson, nws ua lag luam liPriligynyob rau hauv tshaj 60 lub teb chaws, txawm hais tias tsis yog FDA-tau txais kev pom zoo hauv u. s} kev mob siab dua cov kev mob tshwm sim {}}
TSEEM CEEB:
● Ceev ceev ceev: Peak Plasma Concentration (Tmax) tsis pub dhau 1-2 teev.
● Lub sijhawm luv luv: Tshem tawm sai sai, txo qis cov txiaj ntsig .
Propectivity Epectivity: Cov hom phiaj Serotonin thauj tsis muaj qhov tseem ceeb rau adrenergic lossis dopaminergic receptors .
Mechanism ntawm Kev Ua
DapOxetine txhim kho cov serotonin kev ua haujlwm los ntawm kev hloov pauv ntawm synaptic Episodic siv .
Neurochemical Tshwj Xeeb:
●Khi rau soert (serotonin transporter) nrog 3x ntau dua affinity tshaj lwm ssris .
●Zam kev ua kom ntev ntev receptor square, txo kev tshem tawm kev pheej hmoo txaus ntshai .
Cov Ntawv Thov Kev Kho Mob
1. theem theem pib:
●Txhais los ntawm lub neej thaum ntxov ejaculation (<1 minute). Dapoxetine extends intravaginal ejaculatory latency time (IELT) by 2–4x in clinical trials.
2.} nrhiav pe:
●Theem nrab rau kev siv hlwb lossis kev khomob (e {{}}
{{0 {}} tawm ntawm cov ntawv sau npe:
●Kev tshawb nrhiav rau PE Comorbid nrog erectile kawg (ua ke nrog PDE5 inibitors) .
Kev tsis suav:
●Tsis yog rau kev ntxhov siab lossis ntxhov siab tsis txaus ntseeg .} ine contraindicated nrog ssris / maois vim serotonin syndrome kev pheej hmoo.
Cov txiaj ntsig ntawm Dapoxetine
1. ua tau zoo:
●Hauv Randomized Kev Sim, 30 MG thiab 60 mg thiab 60 mg thiab 60 .}}} {feeb, nrog 75% ntawm cov txiv neej qhia kev txhim kho kev tswj hwm.
2.} kev cuam tshuam psycological:
●Txo kev kub ntxhov ntawm kev ntxhov siab thiab txhim kho kev txaus siab rau kev txaus siab {}}}
3.}} yooj yim:
●On-xav tau koob tshuaj tiv thaiv kom tsis txhob muaj kev kho mob txhua hnub kev kho mob.
4.} kev nyab xeeb profile:
●Qis dua ntawm kev mob tshwm sim ntev ntev (e {{1} g}!
Muab thiab tswj hwm
Thaum pib raws tu qauv:
● 30 mg: Noj 1-3 teev ua ntej sib deev {{2} yoog li 60 mg yog tias tsis txaus teb {}}
● Max zaus: Ib hnub .
Lub tswv yim lub tswv yim:
●Pib nrog 30 mg los ntsuas kev thev taus (e {{1} g ., kiv cua).
●Zam dhau li 60 mg vim cov kev mob tshwm sim-kev mob tshwm sim .
Kev Sib Tw Khoom Noj Khoom Haus:
●Cov zaub mov muaj rog muaj rog ntev ntev; tswj hwm ntawm lub plab khoob rau kev ua kom zoo tshaj tmax .
Kev kho suab thiab ua ntej
Tsis zoo li Anabolic Steroids, Dapoxetine tsis muaj lub voj voog "." kev siv yog kev tshwm sim-tsav:
Faib: 3-4 koob tshuaj txhua lub limtiam, nyob ntawm kev sib deev .
● Siv sijhawm ntev: Muaj kev nyab xeeb rau kev siv cov lej sib txawv ntau xyoo, ib qho kev lag luam tom qab kev lag luam .
● Kev txiav tawm:
Tsis muaj tapering yuav tsum . txoj kev nkhaus cia li tsis ua rau SSri rho tawm ssri tshem syndrome {}}
Pharmaconinetics
● Ib nrab-lub neej: 1 {{. 5 teev (vs . 24+}} sijhawm}}} sijhawm fluoxetine).
● Metabolism: HEPATICAL CYP3A4, CYP2D {{}}
● Excretion: 42% renal, 51% quav .
Kev sib cuam tshuam yeeb tshuaj:
● Contraindicated: Nrog Maois, tramadol, lossis lwm yam tshuaj serotonergic .
Kev Sib Tham Sib Tw: CYP3A4 inibitors (e . g}!}}, Ketoconazole nce Dapoxetine qib {}}
Kev Txiav Txim Siab Ua Ntej (PTC)
1.} Tus Neeg Mob Kuaj:
●Txoj cai tawm cov organic ua rau (e {{{0} g}}}}}}
●Ntsuam xyuas kev noj qab haus huv (syncope kev pheej hmoo) {.
2.} contrainmentications:
●Hepatic puas, kev puas siab ntsws bipolar, lossis tswj tsis tau kub siab .
3. Cov Lus Qhia:
●Qhia txog kev coj cwj pwm cwj pwm (e {{{0} g.}}}, Start-Nres Txoj Kev) nrog rau cov tshuaj {}
Kev tsis zoo tshwm sim
Ntau (ntau dua los yog sib npaug rau 10%):
●Xeev siab (22%), kiv taub hau (12%), mob taub hau (11%) .
●Mitigated los ntawm pib ntawm 30 mg thiab hydration .
Tsawg (<1%):
●Syncope, iabism, mus ob peb hlis hloov .
Cawv kev sib cuam tshuam:
●Potenticals orthostatic hypotension; Zam kev siv cov siv hloov pauv .
Piv sib piv tau zoo dua Lwm Txoj Kev
1.} tshuaj loog:
●Dapoxetine zam kev zam kev mob caj ces lossis tus khub hloov teeb meem .
2.} Hnde SSRIS:
●Tsis muaj kev sib daj sib deev sib daj sib deev lossis rho tawm thaum tsis ua haujlwm ntxiv .
3. tramadol:
●Qis dua kev muaj peev xwm .
Tus neeg mob-centric mus ua si
Kev Kawm Txog:
●{32- tus txiv neej muaj sia nrog lub neej zoo siab -} tus cwjpwm kev ua kom zoo dua qub ntawm {}}}} lub hlis taug qab-up {8}
Tus nqi txiav txim siab:
●Generic version (e {. g .,Duralast) Txo cov nqi siv los ntawm 60% hauv kev lag luam tawm tshiab .
Yav Tom Ntej Cov Lus Qhia
● Kev Kho Kom Zoo: Dapoxetine + Topal Lidocaine rau refractory pe .
● Cov gene-based Dosing: CYP2D6 polymorphism ntsuas rau tus kheej saib xyuas .
Cov ntaub ntawv kho mob
|
Kev Lag Luam Npe |
Kutub, priligy, Duratia, Pentenal -30}, sustinex, Lejam, Dumax |
|
Cas |
119356-77-3,129938-20-1 |
|
Tus hniav loj |
305.421 |
|
Mf |
C21H23Tsis muaj |
|
Kev coj dawb huv |
Saum toj no 98% |
|
Kev tsim nyog |
Dawb crystalline hmoov |
Kev xav tau, thov hu rau peb
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Tag
Dapoxetine RuputyIZ ROUNCH ROULGEY PE TSWJ XEEM LOS NTAWM NWS LUB CAIJ NTUJ CEEB TOOM, nws. {1} {1} {{1} .
Cim npe nrov: Dapoxetine Kho rau Kev Ua Ntej Ejaculation Ua Ntej: {{} ij} {{{129938-20-1 Cov chaw tsim khoom, cov chaw tsim khoom, Hoobkas
