Superior Quality Melanotan II Powder Rau Promotes Skin Tanning CAS: 121062-08-6

    Nws Yog Dab Tsi: Tshaj li Lub Ntsiab Lus Txhais

Cov lus piav qhia feem ntau nres ntawm "synthetic peptide rau tanning." Cia peb mus tob dua. Superior Quality Melanotan II yog cyclic lactam analog ntawm -melanocyte-stimulating hormone ( -MSH). Qhov ntawd yog cov phau ntawv kab. Tab sis ntawm no yog qhov txhais tau tias: nws yog cov saw hloov ntawm cov amino acids (Ac-Nle-cyclo[Asp-His-}D-Phe-Arg-Trp-Lys]-d a H2) Cov qauv cyclic no tseem ceeb heev-nws tiv thaiv cov enzymes tawg hauv lub cev zoo dua li cov kab peptides. Qhov zoo tshaj plaws yog hais txog purity thresholds siab tshaj 99%, txheeb xyuas los ntawm HPLC thiab huab hwm coj spectrometry, nrog endotoxin qib qis dua 1 EU / mg. Pharmaceutical-qib synthesis siv cov txheej txheem- theem, tom qab ntawd lyophilizes (khov-dries) qhov tshwm sim rau hauv cov hmoov dawb, dawb, fluffy hmoov. Qhov "superior" txawv qhov teeb meem vim hais tias degraded los yog impure batches qhia unpredictable phiv - tsis sib xws tan tis, xeev siab heev, los yog darkening ntawm uas twb muaj lawm moles nyob rau hauv ib tug ceev, asymmetrical txoj kev.

Tsis zoo li Melanotan I, uas yog linear thiab qeeb dua - ua yeeb yam, Melanotan II's cyclic daim ntawv tso cai rau nws hla cov ntshav - hlwb teeb meem ntau dua. Qhov no tsis yog tsuas yog tus neeg sawv cev tanning; Nws yog ib qho neuropeptide uas cuam tshuam kev qab los noj mov, libido, thiab arousal txoj kev. Qhov ob qhov xwm txheej cais nws los ntawm txhua qhov chaw bronzer lossis UV rooj sib tham. Thaum koj rov ua dua cov hmoov nrog dej bacteriostatic, koj tab tom ua kom lub cev ua kom lub cev ua haujlwm ib txhij qhia melanocortin-1 receptors (MC1R) hauv koj cov tawv nqaij thiab melanocortin-4 receptors (MC4R) hauv koj lub hypothalamus. Ib qho txiaj ntsig yog eumelanin ntau lawm (dub xim). Lwm qhov yog txo kev tshaib kev nqhis thiab spontaneous erections nyob rau hauv cov txiv neej. Tsis muaj lwm txoj kev tanning nqa qhov profile.

   

 

1. Purity raws li kev ntsuas kev ua tau zoo
Standard qib MT2 tej zaum yuav muaj 98-98.5% purity. Qhov uas ploj lawm 1.5% tsis yog qhov tsis muaj teeb meem muab tub lim-nws yog ntu ntu ntu, oxidation byproducts, lossis cov kuab tshuaj seem ntawm qhov tawg. Cov kab mob no tsis yog dilute cov nyhuv xwb; lawv sib tw rau receptor binding, txhais tau tias koj xav tau ntau dua koob tshuaj kom pom kev tsaus ntuj. Qhov phem tshaj, impurities ua rau xeev siab thiab ntuav ntawm lub ntsej muag. Cov hmoov zoo tshaj plaws qhia tau hais tias tib lub ncov ntse ntawm HPLC chromatogram. Koj yuav pom daim ntawv pov thawj ntawm kev txheeb xyuas (COA) cov npe seem TFA (trifluoroacetic acid) hauv qab 0.1% thiab acetate ntsev cov ntsiab lus txheem rau solubility. Qhov no theem ntawm refinement dissolves kiag li nyob rau hauv 1ml dej tsis muaj cloudiness los yog particulates.

2. Hygroscopic tuav
Txawm tias hwm MT2 hmoov absorbs ambient noo nyob rau hauv vib nas this ntawm qhib lub vial. Qhov ntawd yog qhov tshwj xeeb, tsis yog kab laum - nws qhia tias lyophilization tshuav nws qhov ntxeem tau thiab nto - nquag. Tab sis nws kuj txhais tau tias koj yuav tsum khaws cov vials desiccated ntawm -20℃kom txog thaum rov tsim dua. Superior batches raug kaw hauv qab argon roj los tiv thaiv oxidation thaum khaws cia. Cov neeg muag khoom pheej yig dua hla qhov no, thiab koj yuav pom clumping tom qab ib hlis hauv lub tub yees.

3. Kev hloov kho tus cwj pwm
Thaum koj ntxiv dej bacteriostatic rau saum -tier vial, cov hmoov yaj yuav luag tam sim ntawd yam tsis muaj cua sov lossis cua sov. Tsis xav tau vortexing. Yog tias koj yuav tsum co nws lossis tos 60 vib nas this, cov peptide tau sib sau ua ke - qhov ntawd yog qhov tsis ua haujlwm huv. Tsim nyog MT2 tsim cov kua ntshiab, tsis muaj xim nrog pH ntawm 4.5 thiab 5.5. acidic heev (pH<4) means residual solvents; too basic means degradation.

Yog lawm, qhov kev siv tseem ceeb yog UV-kev ywj pheej melanogenesis. Tab sis cov ntawv thov tau faib ua ob qhov tiag - ntiaj teb scenarios:

Kev txhaj tshuaj subcutaneous rau kev tswj qhov tsaus ntuj
Tib neeg siv 31- ntsuas cov koob tshuaj insulin (0.3ml lossis 0.5ml) txhawm rau txhaj rau hauv cov rog ntawm lub plab lossis ncej puab. Lub hom phiaj tsis yog "tau xim av." Cov neeg siv kev paub dhau los tswj lub sijhawm: txhaj tshuaj 30 feeb ua ntej tswj kev tiv thaiv UV (ntuj tshav ntuj lossis qis- lub txaj siab tanning) kom nthuav dav cov nyhuv. Yog tsis muaj UV, MT2 tseem tsim cov xim, tab sis nws yuav siv sij hawm 2-3 lub lis piam ntev dua thiab yields greyish-xim av es tsis txhob golden bronze. Lub synergy nrog UV yog vim MC1R upregulation-peptide primes melanocytes kom txawm tias 5 feeb ntawm nruab nrab hnub ci tsim ib lub lim tiam tus nqi ntawm tan.

Tawm -Label Neurological Effects
Qee tus neeg- tsis xis nyob- siv MT2 rau kev noj qab haus huv thaum lub sij hawm txiav. MC4R ua kom txo qis ghrelin secretion, ua rau lub ntuj caloric tsis txaus yam tsis muaj stimulants. Lwm tus (dua, tawm -label) siv nws rau libido li, txawm hais tias cov txiaj ntsig tsis tuaj yeem kwv yees: ib nrab ntawm cov neeg siv qhia txog kev txhim kho erections 30-90 feeb tom qab- txhaj tshuaj; lwm tus ib nrab xav tsis muaj dab tsi. Kuj tseem muaj cov ntawv thov tshwj xeeb hauv kev kho mob anorgasmia-cov ntaub ntawv qhia, tsis yog kev tshawb fawb-qhov twg MT2 txo qis qhov pib rau ejaculatory latency. Tsis muaj qhov no hloov kho kev kho mob, tab sis nws yog ib feem ntawm cov khoom siv hauv av.

Tshaj tawm -Kub Repigmentation
Rau cov tib neeg uas muaj cov kab mob vitiligo hauv cheeb tsam los yog cov qog nqaij hlav, micro- noj MT2 (50mcg rau ib qho tshuaj, txhua hnub) nyob ib ncig ntawm thaj chaw cuam tshuam tau pom tias rov ua dua tom qab 8 lub lis piam. Qhov no ua haujlwm vim tias peptide tsis yog ua rau melanin synthesis xwb - nws ua rau melanocyte proliferation thiab dendrite extension. Lub npe scientific rau cov txheej txheem ntawd: melanoblast migration. Cov hmoov zoo tshaj plaws ua kom cov molar concentration zoo ib yam kom microneedling lossis derma - dov ua ke nrog cov tshuaj pleev ib ce tiag tiag nkag mus.

Cia peb hla txoj kev lag luam hype. Nov yog cov txiaj ntsig tiag tiag, ntsuas tau:

1. Kev tiv thaiv tsis muaj xim txiv kab ntxwv
Topical DHA (dihydroxyacetone) tsim cov txiv kab ntxwv tint vim nws hnov ​​​​mob nrog cov kab mob stratum corneum tuag. MT2- tsim melanin deposits nyob rau hauv basal keratinocytes. Qhov ntawd txhais tau hais tias tus tan zoo li ntuj -xim av, tsis yog tooj liab-txiv kab ntxwv- thiab nyob rau 4-6 lub lis piam raws li cov cell tsiv mus rau pem hauv ntej. Qhov tseem ceeb tshaj, cov tan muab qhov tseeb SPF zoo li cov nyhuv ntawm kwv yees li 3-5. Qhov ntawd tsis txaus rau hnub puam, tab sis nws tiv thaiv cov erythema tam sim ntawd (sunburn) teb. Cov neeg uas hlawv tom qab 10 feeb nyob rau lub caij ntuj sov pom lawv tuaj yeem tawm 40 feeb yam tsis muaj xim liab tom qab 2-lub lim tiam MT2 thauj khoom theem.

2. Tsis muaj qhov tsis sib xws
Tus kheej - tanners streak vim tias koj nco cov chaw lossis hws. MT2 faib cov txheej txheem. Txawm li cas los xij-thiab qhov no tsis tshua muaj hais txog- qhov tan tshwm sai tshaj plaws ntawm thaj chaw uas muaj ntau dua MC1R receptors: ntsej muag, hauv pliaj, thiab sab ceg. Lub cev thiab rov qab darken qeeb. Cov hmoov zoo zoo sib xws txhais tau tias koj tuaj yeem cia siab tias gradient thiab kho UV raug raws li (ntau dua UV nyob tom qab, tsawg dua ntawm lub ntsej muag).

3. Eumelanin Dominance Tshaj Pheomelanin
Cov taub hau liab thiab ncaj ncees- cov neeg tawv nqaij muaj qhov tsis zoo MC1R uas nyiam pheomelanin (liab- xim daj, tsis muaj UV tiv thaiv). MT2 overrides uas los ntawm kev yuam kom receptor activation. Tshaj li 4-8 lub lis piam, pheomelanin-rau-eumelanin piv hloov pauv. Cov neeg siv cov plaub hau liab tau tsim lub suab xim av-bronze, tsis yog qhov kub hnyiab uas lawv tau siv los. Qhov no yog tib txoj kev los hloov koj daim tawv nqaij cov duab ntawm Fitzpatrick I mus rau III.

4. Ntev ntev Post-Lub voj voog
Lub sijhawm thauj khoom ntawm 2-3 lub lis piam ua rau lub siab tshaj plaws. Tom qab ntawd, txawm tias koj tso tseg kev txhaj tshuaj tag nrho, cov xim ploj mus rau 50% kev siv ntau tshaj 6 lub lis piam. Muab piv rau lub txaj UV, uas ploj mus rau hauv paus hauv 10-14 hnub yam tsis muaj kev saib xyuas. Qhov txawv yog vim melanin cov tshuaj ib nrab-lub neej nyob rau hauv lub epidermis-txog 4 lub lis piam-ntxiv rau qhov tseeb tias MT2 induces melanocyte hypertrophy (cov hlwb loj uas tsim cov xim ntev).

Tsis nco qab tus qauv "0.5mg ib hnub" cov lus qhia. Qhov ntawd yog ib qho -loj- haum- tsis muaj txoj hauv kev. Kev siv tau zoo nyob ntawm peb qhov sib txawv: koj qhov pib ntawm daim tawv nqaij, koj qhov kev nkag mus rau UV, thiab koj qhov kev mob tshwm sim. Nov yog cov txheej txheem tier siv los ntawm cov neeg muaj kev paub dhau los:

Ultra -Kuaj Tsis Txaus (50-100mcg)- Rau Fitzpatrick I-II (ib txwm hlawv, tsis txhob tan). Pib ntawm no. Txhaj 50mcg txhua hnub rau thawj lub lim tiam. Tseem tsis tau pom UV. Yog tias tsis xeev siab, ua rau lub ntsej muag, lossis yawning (yog, MT2 ua rau yawning ntawm melanocortin receptors hauv cov hlab ntsha trigeminal), nce mus rau 100mcg. Tom qab 7 hnub, qhia 10 feeb ntawm nruab nrab hnub txhua hnub.

Standard Loading Dose (250-300mcg ib hnub twg)- Rau Fitzpatrick III-IV (tan nrog nyuaj, tsis tshua muaj hlawv). Txhaj 250mcg 30 feeb ua ntej UV. Siv UV txhua hnub rau 14 hnub. Tom qab 14 hnub, txo qis rau 125mcg ob zaug hauv ib lub lis piam raws li kev saib xyuas. Tsis txhob ntau tshaj 300mcg ib hnub; cov koob tshuaj ntau dua tsuas yog nce xeev siab yam tsis tau ua kom lub tan.

Cov koob tshuaj hnyav (500mcg - tsis pom zoo)- Qee cov neeg siv thawb mus rau 500mcg kom tsaus ntuj sai sai hauv 7 hnub. Kev lag luam tawm -tawm: xeev siab hnyav (ntev 2-3 teev tom qab- txhaj), tsaus nti ntawm cov moles uas twb muaj lawm mus rau xim dub, thiab freckles tshiab ntawm xib teg / ob txhais taw. Cov kev hloov no feem ntau mus tas li. Superior zoo hmoov tsis txo qhov kev pheej hmoo no-nws tsuas yog ua kom cov kev mob tshwm sim los ntawm cov tshuaj, tsis yog los ntawm impurities.

Reconstitution Math- Ib 10mg vial: ntxiv 2ml bacteriostatic dej. Qhov no yields 5mg ib ml. Yog li 0.05ml (5 units ntawm 0.3ml syringe)=250mcg. Siv 0.3ml insulin syringe nrog ib nrab -unit markings rau precision qis dua 100mcg.

Lub Limtiam 1-2: Loading Theem
Txhaj 250mcg txhua hnub (los yog 100mcg yog tias ncaj- tawv). UV raug txhua hnub, pib ntawm 5 feeb thiab nce 2 feeb txhua qhov kev sib tham. Nres yog tias koj hnov ​​​​qhov kub hnyiab -uas yog UV puas, tsis yog tanning. Lub hom phiaj hauv lub lim tiam 1 tsuas yog ua kom melanocytes; Qhov tseeb pom qhov tsaus ntuj feem ntau tshwm nyob nruab nrab ntawm hnub 4 thiab 7. Yog tias tsis muaj kev hloov pauv los ntawm hnub 10, nce koob tshuaj rau 300mcg rau 4 hnub ntxiv, tom qab ntawd rov ntsuas dua.

Lub Limtiam 3-4: Taper Phase
Thaum koj ncav cuag koj qhov xav tau ntxoov ntxoo (uas yuav tsum yog 1-2 ntxoov ntxoo tsaus dua li koj lub suab nrov, vim tias dhau-tanning zoo li av nkos), txo qis rau 125mcg txhua hnub. UV raug ob zaug hauv ib lub lis piam ntawm ib nrab ntawm lub sijhawm thauj khoom lub lim tiam. Qhov no tuav lub ncov tsis muaj overshooting.

Lub Limtiam 5-12: Theem Kho
125 mcg ib lub lim tiam. UV raug: 10 feeb ib zaug hauv ib lub lis piam, nyiam dua rau hnub txhaj tshuaj. Yog tias koj hla UV tag nrho thaum lub sijhawm tu, lub tan yuav ploj mus rau 30% kev siv ntau tshaj 6 lub lis piam, tab sis nws yuav tsis ploj tag nrho. Cov neeg uas nyob rau sab qaum teb latitudes (lub caij ntuj no) feem ntau xav tau ib qho kev sib ntsib UV txhua ob lub lis piam los khaws cov xim.

Lub Limtiam 13 txuas ntxiv mus: Off Cycle
Tso tseg txhua qhov kev txhaj tshuaj tsawg kawg yog 8 lub lis piam. Qhov no tsis yog qhov kev txiav txim siab -melanocortin receptors downregulate tom qab ntev raug. Txuas ntxiv 12 lub lis piam dhau los ua rau txo qis rov qab; koj yuav xav tau koob tshuaj ntau dua rau cov nyhuv tib yam. Tom qab 8 lub lis piam ntxuav tawm, receptor rhiab heev rov qab los. Qee cov neeg siv tau tshaj tawm tias lub voj voog thib ob ua rau cov txiaj ntsig tsaus dua nrog ib nrab ntawm kev thauj khoom.

Ntawm no yog qhov uas feem ntau piav qhia tau tub nkeeg. Kev tshem tawm ib nrab-Lub neej ntawm MT2 hauv tib neeg yog kwv yees li 33-36 teev thaum ntsuas los ntawm plasma concentration. Tab sis qhov ntawd yog qhov kev faib ib nrab-lub neej. Covua haujlwmib nrab-lub neej- ntev npaum li cas cov teeb liab tanning txuas ntxiv mus- yog ze rau 48-72 teev vim tias MC1R receptor tseem nyob sab hauv thiab ua haujlwm tom qab khi.

Peak Plasma Concentration- Tom qab txhaj tshuaj subcutaneous, koj ntaus Cmax ntawm 90-120 feeb. Tias yog vim li cas koj txhaj tshuaj 30-60 feeb ua ntej UV: qhov chaw nyob receptor yog qhov zoo tshaj plaws thaum UV induces DNA puas, ua rau pom kev hloov melanin.

Terminal Ib nrab -Lub Neej – The compound is cleared primarily by renal excretion and proteolytic degradation. In humans with normal kidney function (eGFR >90), cov kab mob tseem nyob hauv cov zis mus txog 5 hnub tom qab ib koob tshuaj 250mcg. Hauv kev xyaum, qhov no txhais tau hais tias yog koj txhaj tshuaj rau hnub Monday thiab hla hnub Tuesday, hnub Wednesday cov ntshav tseem yog 40% ntawm hnub Monday lub ncov. Tias yog vim li cas txhua txhua -lwm- hnub dosing ua haujlwm: koj tsis txhob sib sau ua ke rau sab- cuam tshuam qhov pib thaum tswj kev ua kom receptor.

Kev ua ub ua no- Txawm tias tom qab peptide tshem tawm, melanocytes tseem tsim melanin rau 3-5 hnub vim muaj kev txhawb nqa tyrosinase enzyme upregulation. Qhov no yog lub ntsiab lus tseem ceeb: koj tsis xav tau UV txhua hnub. UV hnub Monday thiab Thursday nrog MT2 ntawm ob hnub tau txais txiaj ntsig zoo ib yam li UV hnub Monday, Wednesday, Friday. Lub enzyme outlass peptide.

Cov npe lag luam	MT2
CAS	121062-08-6
Molar loj	1024.180
Formula	C50H69N15O9
Purity	Tshaj 98%
Yam khoom	Dawb crystalline hmoov

 

 

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Qhov zoo tshaj plaws tsis yog hais txog purity xwb- nws yog hais txog kev ncaj ncees ntawm lyophilized ncuav mog qab zib. Tiag tiag MT2 hmoov zoo li cov khoom, me ntsis tawm -dawb disc nyob rau hauv qab ntawm lub vial. Yog tias koj pom cov hmoov xoob txheej txheej phab ntsa, lub vial ntawd ntxhib - tuav thaum xa khoom (lub ncuav mog qab zib sib tsoo). Nws tseem ua haujlwm, tab sis peptide daim ntawv cog lus yuav tau tawg. Tsis tas li, MT2 tiag tiag muaj qhov tsis hnov ​​​​tsw, qaub acetic acid tsw qab thaum qhib -los ntawm cov khoom seem acetate tsis nyob. Tsis muaj ntxhiab tsw txhais tau tias nws khov- qhuav yam tsis muaj kev sib tw sib tw, ua rau cov dej tsis zoo.

Tsis txhob caum tus darkest tan. Ua raws li ib txwm tshwm sim, ploj zuj zus mus, thiab tsis tso koj nrog cov kab dub dub thaum muaj hnub nyoog 50. Siv kom raug, nrog lub voj voog uas saib xyuas koj cov tawv nqaij biology, superior zoo Melanotan II yog tib yam uas tsis yog - tshuaj uas hloov koj txoj kev sib raug zoo nrog lub hnub ci. Siv carelessly, nws yog kev khuv xim nyob rau hauv ib tug syringe. Koj tau txais daim ntawv qhia tiag tiag -tam sim no taug kev tsis muaj kev luv.

Cim npe nrov: Tuam Tshoj zoo tshaj melanotan ii hmoov rau kev txhawb nqa tawv nqaij tanning cas: 121062-08-6, Tuam Tshoj superior zoo melanotan ii hmoov rau txhawb cov tawv nqaij tanning cas: 121062-08-6 manufacturers, lwm tus neeg, Hoobkas