Melanotan II 10Mg rau kev txhawb nqa Tanning Cas: 121062-08-6

Melanotan II? Ib qho khoom siv hluavtaws nrog nuances

Melanotan II tsis yog ib yam tshwm sim tshwm sim. Nws yog aCyclic Heptapeptide(ib txoj saw ntawm xya amino acids) me me engineered xyoo 1980s nyob rau hauv University of Arizona. Nws tsim qauv tau txais kev tshoov siab los ntawm cov qauv ntawm- Melanocyte stimulating hormone ({{1} h} msh), ib qho tseem ceeb endogenous peptide regulating daim tawv nqaij pigmentation, qab los noj mov, thiab kev sib deev.

● Cov qauv tseem ceeb feature - d - Phenyylalanine:Qhov tseem ceeb hloov kho cov mt - i} i-}}}} cov amino acid nrogD - Phenyylalanine(hloov l - phenylalanine). Qhov no zoo li hloov me me confers ob qho loj zoo:

Yelandic Enaboled Stability:D - cov kua roj yog cov tiv taus rau kev rhuav tshem hauv lub cev thiab cov plab zom mov. Qhov no tseem ceeb txuas lub peptide lub sijhawm ntawm kev ua piv rau- msh.

Your Exhede receptor affinity & cov kev ua haujlwm dav:Lub d -} phe7 hloov kho mt mt- i}}} Kuv tseem ceeb rau cov kav dej) thiab MC4R (muaj kev koom tes hauv qab thiab libido). Qhov tseem ceeb, qhov kev hloov kho no tseem muaj cov kev ua si ntawm MC3R IIR thiab MC5R, nthuav tawm nws lub hom phiaj tsim. Qhov no dav receptor ua kom tiav profile yog nruab nrab rau ob qho tib si nws kev ua tau zoo thiab nws cov kev cuam tshuam zoo spectrum.

 

 

Mt {{{}} II ua pov thawj ntau yam tshwj xeeb kws tshuaj tivthaella:

Powent pelent Melanocortin receptor agonism:Nws thawj mechanism yog khi rau thiab ua kom ua kom muaj zog melanocortin receptors, tshwj xeeb yog MC1R ntawm Melanocytes. Kev ua kom ua kom muaj qhov ua kom muaj kev ua kom muaj zog ua rau nce Melanin synthesis (Eumelanin ntau lawm) thiab nws cov khoom xa tawm hauv daim tawv nqaij.

● Ceev faj ceev & hais cov xim:Tsis zoo li kev kawm tiav tshav ntuj, mt - ich tuaj yeem ntxias tau qhov tseem ceeb ntawm kev coj ua, feem ntau yog UV txhim kho thiab "teeb ​​tsa" ziab). Cov nyhuv no feem ntau ntau dua zoo dua thiab ntev dua- ntev tshaj li nws tus neeg ua ntej, Melanotan Kuv (Afamelanotide).

● Qhov kev cuam tshuam zoo:Vim nws ua kom tiav MC3R thiab MC4R, mt- ii exals cov teebmeem dhau ntawm daim tawv nqaij:

○ Tso Cai:Kev ua kom muaj kev mob siab ntawm hypothalamic MC4R muaj zog inhibits qabte, ib lub zoo {{}} cov thwj cim hauv kev tshawb fawb thiab cov neeg siv cov ntaub ntawv.

○ Enhanced Libido & Erection:Kev ua kom muaj kev ua kom MC4R hauv pob txha caj qaum cuam tshuam kev ua haujlwm erectile, ua kom muaj zog tshwm sim thiab muaj kev muaj siab ntau tshaj plaws hauv tus txiv neej thiab poj niam. Cov nyhuv no feem ntau tau hais tshaj li cov nyhuv tanning rau qee cov neeg siv.

○ Tej zaum anti -} Inflammatory cuam tshuam:Melanocortin rov ua haujlwm (tshwj xeeb ntawm MC3R) MC3R) qhov tseem ceeb hauv tib neeg siv mt - i 1 tsis meej.

● Txoj Kev Tswjfwm Kev:Feem ntau yog muab los ntawmsubcutaneous txhaj(hauv qab daim tawv nqaij). Kev txau tshuaj tsuag nasal muaj nyob tau tab sis raug kev txom nyem los ntawmtsis tshua muaj neeg txom nyem thiab tsis muaj peev xwm ua tau(feem ntau<2%), making them largely ineffective and unreliable compared to injections. Oral bioavailability is negligible due to rapid digestion.

● Metabolism:Feem ntau metabolized los ntawm peptidases hauv ntau daim ntaub. Nws d - Amino acid cov ntsiab lus qeeb, tab sis tsis tshem tawm, qhov no puas. Metabolites yog excreted renally.

Mt {- ich ''s kev loj hlob tau pib tsav los ntawm kev kho mob tshwj xeeb:

● Kev Sau Ntawv:Cov tub ntxhais lub ntsiab. Los ntawm kev txhawb nqa kev tiv thaiv kev tiv thaiv Eumelanin - nplua nuj tanua ntejUV kis (zoo li sunbathing lossis ntaub ntawv xov tooj), mt {}}}}}}}}}} kev pheej hmoo ntawm cov tawv nqaij). Qhov no piv rau kev pom zoo siv ntawm Melanotan Kuv (scenele) rau erythropoietic protoporphyria (EPP).

● Erectile kawg (ED):Thaum pib kho mob thaum ntxov tshawb txog nws lub peev xwm los kho ed (piv txwv li cov metabolite, "}}}} Mt - Ii nws tus kheej pom kev ua tau zoo tab sis kev loj hlob tau halted vim cov kev mob tshwm sim.

● Kev pham:Kev noj qab haus huv ntawm MC4R kev ua haujlwm yog qhov tseem ceeb ntawm kev tshawb fawb.

Txawm li cas los xij, mt - II yeej tsis tau txais kev cai tso cai (FDA, EMA, thiab lwm yam) rau ib qho qhia tau.Nws cov ntawv thov tam sim no nkaus xwbtawm - daim ntawv lo thiab tsis muaj feem, tsav los ntawm cov neeg siv khoom siv feem ntau rau:

1.Rapid "Sunless" Tanning:Kev siv tseem ceeb, nrhiav cov xim sib sib zog nqus nrog cov UV minimal tsawg.

2.Libido li:Siv nws lub zog pro - kev sib deev sab.

3.Metite kev hloov pauv / poob phaus:Siv los ntawm qee qhov rau nws cov nyhuv anorexigenic.

Nws yog qhov tseem ceeb heev rau kev sib tham txog "cov txiaj ntsig" nyob rau hauv cov ntsiab lus ntawm kev siv cov khoom tsis tsim nyog, tsis muaj kev pheej hmoo nrog loj txaus ntshai. Muaj peev xwm cuam tshuam nrhiav los ntawm cov neeg siv suav nrog:

● Ceev thiab tseem ceeb ziab:Ua tiav qhov sib sib zog nqus ziab kom sai dua li lub hnub ci ntsa iab, feem ntau tsis pub dhau lub lis piam.

Txo cov kev xav tau rau lub sijhawm ntev UV raug: Neeg ua dawbtuaj yeem txo qhov kev puas tsuaj UV kev puas tsuaj piv rau kev ua tiav tib theem theem ib txwm muaj,yogUV kis tau yog nruj me ntsis. Txawm li cas los xij, ntau tus neeg siv sib txuas mt - ich nrog UV, negating cov txiaj ntsig muaj peev xwm no thiab kev pheej hmoo mob hlwb.

● Enhanced libido thiab kev sib deev ua haujlwm:Cov txiaj ntsig muaj txiaj ntsig tau qhia los ntawm ntau tus neeg siv.

● Appetite Txiaj:Tuaj yeem ua kom txo qis caloric kom tsawg.

Muaj Peev Xwm Muaj Peev Xwm Muaj Peev Xwm:Qee tus neeg siv qhia txog kev zoo siab me lossis muaj peev xwm txuas nrog melanocortin txoj kev sib cuam tshuam nrog dopaminerergic tshuab, txawm tias tsis nkag siab.

Tsis muaj kev pom zoo los ntawm kev pom zoo los yog muaj kev nyab xeeb thoob ntiaj teb rau mt - ich.Cov ntaub ntawv stems los ntawm cov neeg siv cov kev paub, tsis muaj kev tshawb fawb tsawg, thiab cov lus qhia hauv av. Kev ceev faj heev yog qhov tseem ceeb:

● Pib lub xeem yog qhov yuav tsum tau ua:Vim tias cov kev mob tshwm sim tseem ceeb (tshwj xeeb yog xeev siab), pib qis heev yog qhov tseem ceeb. Sib xwstus neeg siv -} tshaj tawmPib cov ntsiab lus yog100-250 McG (0.1 - 0.25} mg)txhaj subcutaneously.

Ntsuam xyuas kev ua siab:Dose feem ntau yog nce qeeb, los ntawm 100-250 mCG nce ntxiv txhua ob peb hnub, raws li ntawm kev tsim nyog rau cov kev mob tshwm sim (feem ntau xeev siab los yog libido nyhuv.Tsis txhob tshaj 1mg ib zaug yam tsis muaj kev ceev faj heev.

Calce (Thaum pib tau txais txhua hnub, feem ntau nyob rau yav tsaus ntuj tsaug zog los ntawm xeev siab. Thaum lub hauv paus pib tsim los yog cov kev mob tshwm sim ruaj khov, zaustauTxo rau 2-3 zaug hauv ib lub lim tiam rau kev saib xyuas.Nws tsis muaj lub hauv paus scientific rau cov sijhawm zoo tshaj plaws.

● UV Raug:Thaum Mt - ich tuaj yeem ua haujlwm tsis muaj UV, feem ntau cov neeg siv nkagtswj kavUV kis (hnub ci lossis tanning txaj) 2-3 zaug hauv ib as thiv los txhim kho thiab "teeb" ziab. Qhov no UV raug coj nws tus kheej cov kabmob kheesxaws tseem ceeb thiab kev pheej hmoo laus.Sib txuas mt - ii nrog UV yog kev phom sij tshwj xeeb.

● Npaj:Lyophilized (khov -}} qhuav) hmoov yuav tsum muaj cov dej rov qab nrog cov dej sib kis. Cov txheej txheem tsis muaj menyuam tsis yog- kev sib ceg kom tiv thaiv tus kab mob. Dosing yuav tsum tau cov tshuaj insulin formulin (0.3ml lossis 0.5ml, 29-31 gauge koob).

● Nasal tshuaj tsuag cav:Zam kev. Dosing yog qhov tsis sib haum xeeb thiab tsis muaj txiaj ntsig.

Nws tsis muaj kev sib txheeb. Tus neeg siv kev cai sib txawv vary:

● Chaw thau khoom theem:7-14 hnub ntawm kev txhaj txhua hnub kom nrawm nrawm tsim cov xim xim thiab saturate receptors. Siab tshwm sim ntawm cov kev mob tshwm sim.

● Kev kho cov theem:Txo cov zaus (piv txwv li, 2-3 txhaj rau ib lub lim tiam) los tuav ziab thiab / lossis libido cuam tshuam.

● Duration:Cycles feem ntau kav 4 - 12 lis piam. Qee tus siv siv sijhawm sib txuas ntxiv; lwm tus siv tsis tu ncua. Kev cuam tshuam ntev yog tsis paub.

Reverance:Downregulation ntawm Melanocortin cov khoom siv yuav tshwm sim nrog kev siv lub sijhawm ntev, muaj feem txo cov teebmeem (tachyphylaxis), nws xav tau siv ntau zuj zus lossis tawg. Qhov no nce kev pheej hmoo.

● Ntshav ib nrab - lub neej:Kev tshawb fawb qhia tau mt - ich muaj ib tug kujluv ntshav ib nrab ib nrab - lub neej ntawm kwv yees li 1.5 txog 2.4 teevCov. Qhov no txhais tau hais tias kev xav hauv cov hlab ntshav halves hauv lub sijhawm no.

Receptor Cov Haujlwm & Ua Haujlwm Ib Nrab Ib Nrab - Lub Neej:Qhov tseeb, tusua raws liQhov cuam tshuam (tanning, spbido, qab qab noj mov) zaum ntev tshaj li lub plasma ib nrab {}} lub neej qhia - feem ntau 24-7 teev. Qhov no disconnect tshwm sim vim tias:

○ Cov kab mob peptide zawm rau melanocortin receptors.

○ Cov phiajcim lub intracellular taw qhia los ntawm kev ua kom rov ua haujlwm, Mitf Atticts, Melan synthesis mob siab ntev tom qab cov ntshav.

○ Cov neeg siv hluav taws xob nquag, bremelanotide (uas tsis muaj lub c -}} Terminal Amide), kuj ua rau muaj kev ua haujlwm ntev.

Ult Siv qhov cuam tshuam:Lub luv ntshav ib nrab ib nrab - lub neej piav qhia qhov kev xav tau txhua hnub (lossis ze {{- -} Lub caij nyoog ua haujlwm cuam tshuam rau kev siv tshuaj tsawg zaus thaum lub sijhawm tu.

● Kev tsis hwm & feem tsis muaj feem:Mt - ich ii yogtsis pom zooRau tanning, libido, lossis poob phaus nyob txhua qhov chaw. Nws yog muag rau ntawm cov chaw tsis muaj kev xaiv ntsej muag grey / dub.Zoo, kev coj dawb huv, muaj menyuam tsis muaj menyuam, thiab cov ntsiab lus peptide yog tsis paub meej thiab tsis ntseeg.Kev paug, kev deev (piv txwv li (piv txwv li, nrog rau kev muab cov tshuaj lossis lwm yam tshuaj), thiab hauv qab / tshaj tawm yog qhov phom sij heev.

● Cov kev phiv loj:Ntau thiab feem ntau khaus, tshwj xeeb tshaj yog thaum pib:Kev kho mob hnyav, ua kom dawb huv, lub ntsej muag yaug, qaug zog, qab zib {{}} Txoj kev kho mob ceev ceev sai), mob plab, kiv cua kom huv.Tej zaum muaj peev xwm ntev - cov lus cuam tshuam tsis zoo tau kawm tab sis hais txog.

● Hyperpigmentation & Tshiab Moles:Tuaj yeem ua rau muaj kev tsaus ntuj nti (hyperpigmentation), tsaus nti ntawm quav hnav thiab moles uas twb muaj lawm, thiab muaj peev xwm txhawb txoj kev loj hlob ntawmtshiabmoles (nevi). Qhov no ua rau daim tawv nqaij kev soj ntsuam cov tawv nqaij tawv nqaij tawv nqaij.

● Cov nqaij daim tawv:TusCov tub ntxhais ua phem thiab muaj kev phom sij tshaj plaws.Thaum tsim kho rau cov ntaub phncoprotection, siv mt - iitsis muajnruj kev saib xyuas kev kho mob thiab UV tsawg tsawg yuav muajUa kom tawv nqaij muaj kev pheej hmoo:

○ Nws ua rau meanocytes, lub hlwb uas tuaj yeem dhau los ua melanoma.

○ Cov ziab nws tsim kom muaj kev tiv thaiv kev txwv tsis pab tiv thaiv DNA (SPF ~ 2.

○ Cov neeg siv feem ntau ua rau lawv tus kheej rau UV txhawm rau txhim kho ziab, compounding DNA kev puas tsuaj rau cov hlwb.

○ Cov tawv nqaij tsaus dua tuaj yeem npog qhov ncauj tshiab lossis hloov pauv Moles, ncua melamoma tshawb pom.

● Cov neeg muaj kev pheej hmoo plawv:Melanocortins cuam tshuam cov ntshav siab. Tawg thiab lwm yam kev sib haum xeeb yog qhov kev txhawj xeeb txog kev txhawj xeeb.

● Autoimmune / Inflammatory muaj peev xwm:Melanococortin Pathways hloov kev tiv thaiv. Kev tsis pom tau zoo ntawm autoimmune muaj peev xwm ua tau.

Ive ua haujlwm:Excretion yog lub raum. Cuam tshuam rau lub raum tsis paub tab tsis paub.

● Cov teebmeem kev puas siab puas ntsws:Tej zaum muaj peev xwm hloov pauv thiab vam khom (hlwb lossis lub cev) tsis nkag siab.

● Kev sib cuam tshuam nrog kev kho mob:Kev cuam tshuam rau cov xwm txheej zoo li lub plawv, mob raum, keeb kwm rhiab yog ib qho tsis paub meej) yog tsis paub thiab muaj kev phom sij.

Kev Lag Luam Npe	Melanotan II Ac - -}}}}} lys {} lys] {}- nh2 Ac - -}}}}} lys {} lys] - nh2 AC - cyclo [nle4, ASP5, D - phe7, Lys10] {{{0} sh msh4–10- nh2 N- acetyl {{1} l {{l {{4} {}} d {{8 }} Phenyylalanyl {{l - {l {{l {{14} lysinamide (2 → 7) {- lactam PT-14
Cas	121062-08-6
Tus hniav loj	1024.180
Cov lus ntawm ib txoj kab ke	C50H69N15O9
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	10mg / vial, lyophilized hmoov

 

 

Kev xav tau, thov hu rau peb

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Melanotan II yog lub zog hluavtaws peptide nrog undeniable muaj kev cuam tshuam ntawm pigmentation, libido, thiab qab los noj mov. Nws cov qauv qauv tshwj xeeb cov nyiaj pub rau nws qhov ruaj khov thiab txhim kho kev ua haujlwm dav. Txawm li cas los xij, nws cov xwm txheej uas yog qhov tsis pom zoo, tsis txaus siab tshawb fawb tshuaj lom neeg muag khoom nyob rau hauv lub khw txaus ntshai tsis tuaj yeem ua kom dhau. Cov kev pheej hmoo - suav nrog kev phiv loj, muaj peev xwm rau lub neej zoo, thiab ua kom tiav ntawm cov tawv nqaij tawv nqaij, thiab ua kom tiav ntawm cov tawv nqaij tawv nqaij, cov khoom siv ntev}

Thaum nws cov tshuab kev nqis tes ua yog kev tshawb fawb, cov tswv yim thov ntawm mt {}} i}}}} Daim ntawv lo nrog kev nkag mus rau peril.Kev muab lwm txoj kev nyab xeeb rau kev ua tiav ziab (FDA {{{}}}}} {} (cov kev kawm kom muaj kev sib deev) muaj nyob thiab yuav tsum tau ua raws.Melanotan II sawv cev piv txwv li cas thiaj li ua tau pes tsawg lub chaw muag tshuaj, thaum sib nrauj ntawm kev saib xyuas kev nyab xeeb, thiab kev tswj hwm kev nyab xeeb, ua kev nyab xeeb rau kev noj qab haus huv.

Cim npe nrov: Melanotan II 10Mg rau kev txhawb nqa CASING CAS CAS: 121062-08-6, Tuam Tshoj Melanotan II 101062-6 tuam ntxhab, cov chaw tsim khoom, chaw tsim khoom