Dermorphin rau cov mob taub hau muaj zog: 77614-16-5

Dermorphin yog dab tsi?

Dermorphin yog ib qho tshwm sim heptapeptide (xya amino acids) nrog kev sib lawv liag: H - tyr -}}}}}}}- nh2. Qhov tseem ceeb tshaj plaws tshwj xeeb paub qhov txawv nws los ntawm cov tsiaj txhu cov tsiaj feem ntau yog lub xub ntiag ntawmD - Alanine(D {- ala) ntawm txoj haujlwm thib ob. Yuav luag txhua tus tsiaj mammalian amino acids nyob rau hauv cov protein thiab peptides yog nyob rau hauv lub l- configuration. Qhov no d {{4} amino acid hloov chaw yog enzymatically incorporated Post - txhais tau hais lus thiab yogkiag li tseem ceebTxog rau dermorphin cov kev tshwj xeeb tshwj xeeb thiab tsis kam mus rau enzymatic degradation. Nws ua raws li kev xaiv siab heev thiab muaj zog agonist feem ntau ntawmmu - opioid receptor (mor), tib lub hom phiaj tseem ceeb raws li morphine, fentanyl, thiab yeeb dawb.

 

Factional Potency:Dermorphin yog qhov tseem muaj zog dua li morphine. Kev tshawb fawb kwv yees nws yog30-50 lub sij hawm ntau zog tshaj morphineThaum muab cov tswj hwm intracerebrovularly (ncaj qha rau hauv lub hlwb ventricles) hauv cov qauv qws. Txawm tias peripherally, nws ua rau pom muaj potency.

● D - amino acid tus yuam sij:Lub d - ala residue tsis yog - sib ceg rau kev ua. Cov hluavtaws hluavtaws nrog l - Ala tau zoo tsis nyob hauv. Qhov no d - cov amino acid ua rau dermorths (enzymes uas tawg rau nws lub sijhawm ntev ntawm kev ua piv rau kev ua kom zoo sib xws.

● Cov siab siab - opioid receptor xaiv:Thaum nws tuaj yeem cuam tshuam nrog Delta thiab Kappa receptors nyob rau ntau dua qhov siab, dermorphin nthuav qhia qhov xav tau thiab muaj ib qho siab rau cov mu {}} opioid receptor. Qhov kev xaiv no ua rau nws lub zog ua piv txwv thiab kev zoo siab.

● Metabolic Stability:Lub d - Ala ala thiab c-}}}}}} ح{ល against tiv thaiv nws cov nqaij ntshav thiab cov ntaub so ntswg piv rau cov enkephats. Qhov no pab txhawb rau ib nrab - lub neej tshaj li ntau peptides.

● Ntshav free -} Barrier (BBB) ​​Penetration:Txawm hais tias yog peptide, dermorphin qhia tau zoo heev rau kev nkag mus ntawm BBB, qhov tsis tshua muaj neeg rau peptides. Qhov no yog ib nrab ntaus nqi rau nws lipophilic (rog- soluble) cov yam ntxwv thiab muaj peev xwm ua kom muaj kev thauj khoom hauv nruab nrab cov hom phiaj zoo tom qab kev tswj hwm.

Hom - Cov teebmeem:Nws cov txiaj ntsig txiaj ntsig yog feem ntau pom hauv cov tsiaj yug menyuam. Nyob rau hauv nws cov qav fog hosts, nws txoj haujlwm yog kwv yees kom muaj kev tiv thaiv (deterring predators (tiv thaiv tus kheej lub luag haujlwm ntawm amphibians lub luag haujlwm hauv amphibians tsis tau txhais.

● Cov ntawv thov kev kho mob tib neeg:Raws li kev purely ntawm nws lub zog mor agonism thiab analgesic profile hauv tsiaj qauv, dermorphinyuav inoreticallytau tshawb rau:

○ Tswj mob hnyav, kev mob siab (piv txwv li, mob cancer mob cancer, muaj kev mob siab loj).

○ Ua tus qauv tseem ceeb rau kev tsim cov khoom siv hluavtaws tshiab, piv txwv li kev ua pa zoo dua qub, tsis muaj pov thawj rau dermorphin derivatives).

App Qhov ntawv thov thawj zaug: Doping Voping (fluicit):Kev nyuaj siab, dermorphin cov lus qhia tsis tau zoo li yuav luag txhua tusKev siv tsis raug cai raws li kev ua yeeb yam -} txhim kho cov tshuaj hauv kev sib tw nees.Nws cov kev tshawb pom hauv cov haiv neeg sib tw, tshwj xeeb tshaj yog nyob hauv Asmeskas ib ncig 2012, ua rau pom kev loj. Nws cuam tshuam hauv cov nees ua haujlwm lwm yam tshuaj opioids:

    ○Masking mob:Tso cai rau kev raug mob lossis mob nees kom khiav dhau ntawm lawv cov kev txwv ntuj, tsis quav ntsej cov ntsiab lus uas yuav tsis muab lawv tso rau lawv. Qhov no yog txaus ntshai heev rau tus nees txoj kev noj qab haus huv.

    ○Stimulation & Euphoria:Ua rau "siab" uas tuaj yeem ua rau cov nees khiav ntau nruj lossis muaj ntau zuj zus.

    ○Nce nce qib siab:Los ntawm kev thuam kev mob thiab muaj peev xwm hloov kev pom ntawm kev tawm tsam.

Nws yog qhov tseem ceeb los qhia txog qhov kev siv tam sim no, muaj "cov txiaj ntsig" tsis zoo, thiab tsis raug cai:

● Mob lub ntsej muag (fluicit):Tso cai rau cov tsiaj ua kom tiav rau kev sib tw thaum lawv tsis tsim nyog.

● Kev ua tiav kev ua tiav (fluicit):Peev xwm rau kev nce ceev, thev taus, thiab kev sib tw tsav tsheb hauv cov kev sib tw (vim tias mob ntshav siab thiab zoo siab).

Undetectability (pib):Nws lub keeb kwm keeb kwm thiab peptide cov qauv thaum pib kuaj xyuas nrog cov ntxaij siv yeeb tshuaj sib luag, txawm tias cov kev sim tshwj xeeb tau tsim kho tam sim ntawd nws siv tau.

Qhov tseem ceeb tshaj tawm:MuajTsis muaj kev nyab xeeb lossis kho cov tshuaj, voj voog, lossis raws tu qauv rau dermorphin hauv tib neeg lossis tsiaj.Cov ntaub ntawv hauv qab no yog qhov yooj yim ntawm kev tshawb fawb me me) lossis cov nas uas muaj kev phom sij, tsis muaj kev phom sij, tsis muab kev taw qhia.

● Dosage:Potency yog huab.

Wodent Kev Tshawb Fawb (ICV):Muaj txiaj ntsig analgesic koob tshuaj nyob hauvmicrogram (μg) ib phausntau yam (piv txwv li, 1-10 μg / kg). Qhov no txhais taumilligrams lossis tsawg duaRau ib tug tib neeg, tso nws khov kho nyob rau hauv realm ntawm cov tshuaj zoo li Fentanyl hauv cov nqe lus ntawm kev pheej hmoo ntau.

    ○Doping Veterym:Dosing hauv nees yog clandestine thiab tsis tshaj tawm, tab sis yuav muaj ntau yam me me, muaj feem xyuam rau ntau pua kev raug ntes tam sim ntawd thaum tseem ua pa tau raug ntes thaum tseem ua pa tau raug ntes thaum tseem ua pa tau raug ntes thaum tseem ua pa txawm tias yuav tsum ua pa.Txhua qhov kev sim ntawm tib neeg txoj kev noj tshuaj yuav recklessly txaus ntshai thiab muaj peev xwm ua rau neeg tuag taus.

Caunch ncig:Nyob rau hauv cov ntsiab lus ntawm doping, nws yog tej zaum yuav ua rau ze rau haiv neeg lub sijhawm (hauv cov sij hawm lossis hnub ua kom tiav thaum lub sijhawm ua haujlwm. Tsis muaj lub tswv yim ntawm kev kho mob "kev voj voog."

Ib nrab - lub neej:Cov ntaub ntawv tsuas yog txwv thiab feem ntau los ntawm cov kev kawm sib tw. Kwv yees hais tias aib nrab - lub neej nyob rau hauv thaj tsam ntawm 30 feeb rau ob peb teevTom qab kev tswj hwm kev tswj hwm (zoo li cov khoom siv lossis cov subcutous). Qhov no yog ntev tshaj endogenous peptides zoo li tau ntsib -} molecule opioids zoo li Methadone (teev rau hnub). Nws cov kev nkag mus BBB thiab cov khoom siv rov qab ua rau muaj feem yuav pab txhawb rau qhov kawg ntawm lub plasma ib nrab {}} lub neej yuav qhia. Ib nrab - lub neej nyob hauv cov nees lossis tib neeg tsis paub.

Qhov kev suav nrog "PTC" hauv cov lus nug yog kev xav tsis thoob.PalmooloL Tetrapeptide-7 (PTC-7)yog ib qho tsis muaj kev sib txuam. Nws yog cov hluavtaws peptide thooj (muab tau los ntawm thymosin beta-4) feem ntau siv nyob rau hauvKev kom hniav thiab tawv nqaij tawv.Kev ua lag luam nyob rau hauv cov npe zoo li matrixyl 3000, nws tau thov kom muaj anti {1} pa solagen thiab hyaluronic acid ntau lawm, muaj feem txo wrinkles thiab txhim kho daim tawv nqaij thiab txhim kho tawv nqaij cov tawv nqaij. Nws muajkiag li tsis sib txuasrau dermorphin, opioid receptors, analgesia, lossis kev ua tau zoo dua. Nws tsis yog tshuaj ntawm kev tsim txom thiab ua tim khawv tsis muaj qhov kev txhawj xeeb txog kev nyab xeeb ntawm kev nyab xeeb ntawm cov tshuaj pleev ib ce. Hais txog nws nrog rau Dermorphin yog ib qho yuam kev.

Dermorphin lub hwj chim Mu - opioid agonism txhais tau tias nws nqa txhua qhov kev pheej hmoo hnyav uas tau txais rau opioids, magnified los ntawm nws qhov tshwj xeeb:

Qhov kev nyuaj siab ua pa nyuaj: qhov ua ntej ntawm kev tuag opaioid ntau dhau. Dermorphin suppresses lub hlwb lub tsav ua pa. Muab nws lub potency, cov npoo ntawm "koob tshuaj tivthaiv" ua haujlwm tau txaus ntshai, tshwj xeeb yog tsis muaj cov neeg saib xyuas kev kho mob thiab cov neeg sawv cev rov qab (naloxone).

Kev quav yeeb phem peev xwm: Zoo li tag nrho cov lus agonists tag nrho, dermorphin ua rau muaj kev zoo siab thiab muaj yees. Cia siab rau muaj cov peev xwm sai.

Kev Ua Phim: Ntau Npaum Yuav Tsum Tau Ua kom tiav cov nyhuv tib yam, nce txoj kev pheej hmoo ntawm kev noj ntau dhau.

Kev Tshem Tawm: Kev txiav tawm sai tom qab vam khom ua rau lub cev thiab lub hlwb thim cov tsos mob.

Kev Lag Luam Npe	Tyrosyl- Alanyl - penylalanyl {}}} prolyl {}} serinamide
Cas	77614-16-5
Tus hniav loj	802.886
Cov lus ntawm ib txoj kab ke	C40H50N8O10
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	5mg / vial, 10vials / box

 

 

Kev xav tau, thov hu rau peb

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Dermorphin yog cov lus qhia txog kev ua haujlwm Biochemical - Lub Thamyam rau kev muaj peev xwm los evolve cov tebchaw Neuroactive. Nws cov qauv tshwj xeeb, muaj cov qauv tsis tshua muaj- amino acids, muab cov nyiaj ntsuab}} eciod recepor potency thiab ruaj khov. Txawm li cas los xij, nws zaj dab neeg tau yooj yim dhau ib qho kev phom sij thiab siv tsis raug. Thaum nws ua rau lub txim siab xav paub hauv kev tsim qauv tshiab, kev ua haujlwm tseem ceeb yog qhov kev ua tau zoo, ua rau muaj kev sib tw ntawm nees, ua rau cov neeg tsis txaus siab thiab ua rau muaj kev noj qab haus huv.

Cim npe nrov: Dermorphin rau cov mob taub hau muaj zog: 77614-16-5, Tuam Tshoj dermorphin rau cov tshuaj txhuam hniav muaj zog: 77614-16 Cov Chaw Tsim Khoom, Chaw Tsim Tshuaj, Hoobkas