CJC1295 Nrog DAC 2mg CAS: 446262-90-4

CJC-1295 + DAC yog ib qho kev loj hlob hormone tso tawm cov tshuaj hormones ntev, uas ua rau cov anterior pituitary tso tawm ntau cov tshuaj hormones loj hlob. GHRH raug tso tawm hauv pulses hauv lub cev, uas hloov nrog cov pulses sib xws ntawm somatostatin (kev loj hlob-hormone inhibiting-hormone). Kev tshawb fawb soj ntsuam thawj zaug tau ua rau CJC-1295 thaum nruab nrab -2000s. Lub hom phiaj ntawm peptide yog los kho cov visceral rog deposits nyob rau hauv cov neeg mob rog rog AIDS, raws li kev nce qib ntawm exogenous HGH yog presumed kom lipolysis (fat poob). Cov kev tshawb fawb soj ntsuam tau kawg ua tiav rau feem ntau cov kev tshawb fawb. Ghrelin, tso tawm ntawm lub plab, uas ncig thiab ua raws li kev tshaib kev nqhis, muaj kev sib koom ua ke hauv lub cev nrog GHRH thiab tseem inhibits somatostatin los ua txoj hauv kev rau GHRH mem tes.

Cov kev tshawb fawb qhia tau hais tias kev sib koom ua ke ntawm GHRP-6 nrog CJC-1295 + DAC, nce qhov tso tawm ntawm GH thiab IGF-1 ntau lawm yam tsis muaj qhov nce hauv prolactin. Ib qho piv txwv ntawm GHRP (GH Releasing Peptide) yog Hexarelin lossis GHRP-2. CJC-1295 + DAC yog ib qho tshwj xeeb tsim peptide thiab paub tias yog qhov zoo tshaj plaws ntawm hGH secretogues. Qhov DAC (Drug Affinity Complex) feem ntau ua rau ib nrab-lub neej los ntawm kev khi nrog cov ntshav albumin thiab tiv thaiv CJC-1295 DAC peptide los ntawm degradation. Qhov no tau tsim thaum qhov txuas lysine raug khi rau DACs rau cov tshuaj reactive hu ua maleimidoproprionic acid (MPA).

 

 

CJC-1295 + DAC thiab CJC-1295 (tseem hu ua Modified GRF 1-29) yog ob qho tib si Loj Hlob Hormone Releasing Hormones (GHRH). Lawv qhov kev ua hauv tib neeg lub cev zoo ib yam tab sis qhov sib txawv ntawm ob lub peptides yog qhov ntev ntawm ib nrab-lub neej. Hloov kho GRF 1-29 thiab Sermorelin muaj qhov ua haujlwm luv luv ntawm ib nrab ntawm 30 feeb, thaum CJC-1295 + DAC muaj ib nrab-lub neej uas tuaj yeem kav ntev txog 8 hnub. Ntau tus kws tshawb fawb tau tshaj tawm tias qhov luv luv ib nrab-lub neej ntawm Sermorelin thiab Hloov Kho GRF 1-29 yog suav tias yog ntuj ntau dua vim tias lawv tsim cov mem tes luv ntawm Human Growth Hormone.

CJC-1295 + DAC yog ib qho tetrasubstituted peptide analogue ntawm Kev Loj Hlob Hormone tso cov tshuaj hormones nrog D-Ala, Gln, Ala, thiab Leu hloov ntawm txoj haujlwm 2, 8, 15, thiab 27. Lub tuam txhab Canadian biotechnology hu ua ConjuChem tau tsim CJC{ {6}}. Kev tshawb fawb soj ntsuam ntawm CJC-1295 thawj zaug pib thaum nruab nrab -2000s. Lub hom phiaj ntawm peptide, ua kom nce HGH zoo li Ipamorelin, yog los kho cov visceral rog deposits nyob rau hauv cov neeg mob rog rog AIDS vim hais tias nws yog presumed tias nce qib ntawm exogenous hgH nce rog poob, los yog lipolysis.

Hauv ib txoj kev tshawb fawb, cov txiaj ntsig tau pom tias qhov ntsuas GH tso tawm hauv nas dhau ib lub sijhawm ob teev pom tias CJC-1295 tso tawm ob zaug GH ntau npaum li CJC-1293 + DAC. Qhov kev tshwm sim no ua rau nws zoo dua rau kev ua haujlwm tam sim ntawd raws li qhov tshwm sim ntev dua. Nrog rau kev siv Growth Hormone Releasing Peptide (GHRP), xws li Kev Loj Hlob Hormone Releasing Hexapeptide (GHRP-6) hauv kev sib txuas nrog CJC-1295 + DAC, ib txoj kev tshawb fawb tau pom tias GHRP's tsim muaj Growth Hormone pulse. uas pab CJC-1295 ua haujlwm tau zoo. Kev tshawb fawb soj ntsuam nrog CJC-1295 tau qhia tias nws tau ua tiav rau feem ntau cov kev tshawb fawb.

Kev txo cov rog rog los ntawm kev siv cov rog ua lub zog. Nws tuaj yeem ua rau muaj cov leeg nqaij ntau ntxiv los ntawm kev txhawb nqa cov synthesis ntawm cov protein.
Txij li thaum kev loj hlob hormone txhawb cov pob txha loj hlob thiab txhim kho kev sib koom ua ke thiab cov ntaub so ntswg kev noj qab haus huv, CJC -1295 peptide tuaj yeem txhim kho pob txha loj thiab txo kev raug mob.
Cov kev tshawb fawb tau qhia tias GHRH txhawb nqa cov qauv kev pw tsaug zog ib txwm muaj, qhov ua haujlwm no tuaj yeem txuas ntxiv mus rau cov analogues xws li CJC-1295.

CJC-1295 DAC Peptide Mechanism of Action
Cov kws tshawb fawb tau ua ob qhov kev tshawb fawb soj ntsuam hauv xyoo 2006 los tshuaj xyuas qhov kev txiav txim ntawm CJC-1295. Cov ntawv xeem tau nyob nruab nrab ntawm cov hnub nyoog ntawm 21-61 xyoo. Hauv thawj txoj kev tshawb fawb CJC-1295 lossis placebo tau nthuav tawm hauv ib qho ntawm plaub qhov nce ntxiv. Ntawm qhov tod tes, hauv kev kawm thib ob CJC-1295 tau nthuav tawm ob lossis peb zaug hauv ib lub lis piam. Raws li cov txiaj ntsig, tom qab kev nthuav qhia ntawm CJC-1295, tau tshwm sim tau nce qib GH thiab IGF-I (IGF-1: Insulin-zoo li kev loj hlob yam 1) ntawm cov kev kawm.

Xyoo 2006, lwm pab pawg kws tshawb fawb tau soj ntsuam GH pulsatility tom qab ib qho tshwm sim ntawm CJC-1295. Lawv tau pom tias muaj tshwm sim tau nce li ntawm 50% hauv GH secretion thiab IGF-I theem tom qab ib qho kev nthuav qhia ntawm CJC-1295

Hauv nws daim ntawv qub, CJC-1295 siv thev naus laus zis hu ua Drug Affinity Complex (DAC). Contrary to the GHRH uas muaj ib nrab-lub neej ntawm kwv yees li 7 feeb, CJC -1295 tau tshaj tawm los ntawm cov kws tshawb fawb kom nthuav tawm ib nrab hnub ntev ntawm 6-8 hnub vim DAC thev naus laus zis.

Hauv xyoo 2005, kev tshawb fawb tau pib soj ntsuam cov txheej txheem ntawm kev ua ntawm CJC-1295 hauv cov neeg uas muaj kab mob tiv thaiv kab mob (HIV) cuam tshuam nrog kev rog rog. Hauv txoj kev tshawb no, cov ntsiab lus yuav raug nthuav tawm nrog CJC-1295 rau 3 lub hlis thiab ua raws li 6 lub lis piam tom qab. Txawm li cas los xij, txoj kev tshawb no tau raug txiav tawm thaum lub sijhawm nrhiav neeg ua haujlwm, thiab tsis muaj cov txiaj ntsig cuam tshuam tau tshaj tawm.

Raws li kev tshawb fawb Norwegian, nyob rau xyoo 2009, ib qho kev sib txuas tau xa mus rau kev tshuaj ntsuam xyuas seb nws puas muaj cov tshuaj txwv tsis pub siv los yog tsis. Cov kws tshawb fawb ntawm Norwegian Doping Control Laboratory thiab School of Pharmacy tau tshaj tawm tias cov tshuaj no yog CJC-1295. Hauv lawv tsab xov xwm tshaj tawm lawv tau xaus lus tias "CJC-1295 yog qhov tso tawm rau kev loj hlob hormone".

Khoom npe	DAC, GRF
CAS	446262-90-4
Molar loj	3367.954
MF	C152H252N44O42
Peev Xwm / Lub raj mis	2 mg / vial
Cov duab	Lyophilized hmoov

 

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CJC-1295 nrog DAC yog ib qho hluavtaws peptide uas qee zaum siv hauv thaj chaw ntawm kev ua kis las thiab tshuaj tiv thaiv kev laus. Nws yog ib qho kev hloov kho ntawm kev loj hlob hormone-tso cov tshuaj hormones (GHRH) hu ua CJC-1295. Qhov sib ntxiv ntawm DAC (Drug Affinity Complex) ncua nws ib nrab-lub neej.

CJC-1295 nrog DAC ua haujlwm los ntawm kev txhawb nqa lub caj pas pituitary kom nce kev tsim khoom thiab tso tawm cov tshuaj loj hlob (GH). Kev loj hlob hormone plays lub luag haujlwm tseem ceeb hauv ntau yam txheej txheem physiological, suav nrog kev loj hlob, metabolism, thiab kho cov ntaub so ntswg. Los ntawm kev nce qib GH, CJC-1295 nrog DAC tuaj yeem txhawb kev loj hlob ntawm cov leeg nqaij, rog poob, txhim kho rov qab los ntawm kev tawm dag zog, thiab muaj peev xwm muab cov txiaj ntsig tiv thaiv kev laus xws li txhim kho daim tawv nqaij zoo thiab kev txawj ntse.

Txawm li cas los xij, nws tseem ceeb heev uas yuav tsum nco ntsoov tias kev siv peptides zoo li CJC -1295 nrog DAC sab nraum lub hom phiaj kho mob raug cai thiab tsis muaj kev saib xyuas kev kho mob kom raug yog qhov tsis txaus ntseeg thiab muaj feem pheej hmoo.

 

 

 

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