{{05- amino {{mq peptides rau cas rau lub cev nqaij daim ntawv: 42464-96-0
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a novel small molecule compound, often mistakenly categorized as a peptide due to its niche in metabolic research. Developed to target nicotinamide N-methyltransferase (NNMT), ib qho enzyme txuas rau cov kev tshawb fawb metabolic, nws tawm los ntawm kev tshawb fawb tshawb txog kev rog thiab metabolic syndrome {}}
Taw qhia rau 5- amino {{1 mq
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a novel small molecule compound, often mistakenly categorized as a peptide due to its niche in metabolic research. Developed to target nicotinamide N-methyltransferase (NNMT), ib qho enzyme txuas rau cov kev tshawb fawb metabolic, nws tsis zoo li qub}}}}}}}}}}}} {{9 {9}
Mechanism ntawm Kev Ua
5-Amino-1MQ inhibits NNMT, which typically methylates nicotinamide (a form of vitamin B3), reducing its availability for NAD+ synthesis. By blocking NNMT, cellular nicotinamide levels rise, enhancing NAD+ production. Elevated NAD+ activates sirtuins, protein tseem ceeb rau mitochondrial biogenial biogen numberis thiab lub zog ua kom muaj kev ntxhov siab, thiab txhawb nqa cov leeg nqaij Lipid, thiab txhawb nqa cov leeg ua kom lub cev nqaij daim tawv
Cov Nta Tseem Ceeb
● Cov qauv tshuaj lom neeg: Ib qho quinoline derivative nrog cov methyl pab pawg thiab amino hloov chaw, ua kom ruaj khov thiab qhov ncauj thiab qhov ncauj}
● Cov thawj coj: Feem ntau ntawm qhov ncauj, nrog kev tshawb fawb pom meej sublingual lossis enteric-coated formulations los bypass ua ntej-hla metabolism ua ntej.
Propectivity Epectivity: Lub Hom Phiaj Nnmt yam tsis cuam tshuam lwm methyltransferases, txo cov kev cuam tshuam ntawm hom phiaj-phiaj xwm .
Cov ntawv thov hauv kev ua haujlwm ntawm lub cev
● Rog poob: Txhim kho lipholysis ntawm epregulated nad +- kav txoj hauv kev, tshwj xeeb hauv visceral rog {}}
● Cov leeg tshuaj tiv thaiv: Ua kom Ampk, txhawb kev txuag hluav taws xob thiab txo catabolism thiab txo cov catabolism hauv lub sijhawm caloric tsis txaus ntseeg {}}
● Kev saib xyuas kev ua siab ntev: Txhim kho Mitochondrial Equitic Equiciency txhawb kev kawm ntev ntev kev kawm {}}
● Rov qab nrawm nrawm: Txo cov oxidative kev ntxhov siab thiab oxidation post-ce los ntawm sirtin ua kom .
Cov txiaj ntsig
● Cov rog rog txo: Tsis zoo li stimulants, nws hais tshwj xeeb heev mob tawv nqaij tsis muaj cov leeg ua kom muaj cov nqaij lwj {}}
● Los tiv thaiv kev laus: Nce nad + tej zaum yuav txhim kho cov kev ua haujlwm elasticity thiab kev ua haujlwm zoo, ancillary pab tau cov neeg ncaws pob.
● Cov khoom siv nrawm: Txhim kho hloov ntawm Glycolytic thiab oxidative metabolism thiab oxidative meterolism, tseem ceeb rau kev cob qhia kev cob qhia txog kev sib txawv ntawm cov regudens .
Muab thiab tswj hwm
Kev tshawb nrhiav tsiaj: Nas tau txais 50 mg / kg, mergating ntawm thaj chaw thaj tsam li ~ 4 mg / kg rau ib tus neeg (280 mg rau ib tug neeg) {}}
● Cov ntaub ntawv ceeb toom anecdotal: Cov neeg siv pib nrog 50 mg / hnub, nce rau 100-150 mg faib ua ob zaug kom haum rau ib nrab hnub {}}
● Cycling: {8-12} Lub lim tiam cycles ua raws li los ntawm cov txiaj ntsig NNMT los sis methylation pathwation.
Ib nrab-lub neej thiab sijhawm
Nrog ib nrab-lub neej ntawm ~ 7 teev, noj tshuaj txhua hnub khaws cov roj ntsha ruaj khov thaum sawv ntxov
Tom qab kev cobqhy (Pct)
Raws li 5- amino {mq tsis kam rau metylation nrog kev sau ntawv lossis kev txhawb nqa kev sib deev, tsis muaj kev sib deev}
Kev Nyab Xeeb thiab Kev Mob tshwm sim
● Cov lus luv luv: Me me plab plab tsis xis nyob .
● Cov kev pheej hmoo ntev ntev: Theoretical kev txhawj xeeb txog kev hloov methylation qauv cuam tshuam rau neurotransmitter synthesis; Saib xyuas homocysteine qhia .
Kev Tshaj Tawm
● vs . clenbuterolol: Tsis-txhawb nqa, zam tachycardia lossis shakes .
● VS VS . na nad + precursors (NMN / NRN): Qhia ncaj qha nad + ntawm enzyme inhibition ntau dua li substrate ntxiv, muab cov txiaj ntsig muaj zog.
Raws cai
Tam sim no kev tshawb fawb kev tshawb fawb, tsis pom zoo rau tib neeg kev noj haus {{}}}}}}}} .
Yav Tom Ntej Cov Lus Qhia
Kev txiav txim siab tsis tu ncua tshawb xyuas cov pluas noj thiab kev noj patent kom txaus siab hais txog cov leeg nqaij tsis muaj kev xav rau cov menyuam yaus poob (sarcopenia) {2}
Cov Tswv Cuab Cov Neeg Siv
● Sourcing: Xaiv rau cov neeg muag khoom muab cov coas (daim ntawv pov hwm ntawm kev tsom xam) rau kev coj dawb huv .
● Cia: Ruaj khov nyob rau hauv chav tsev kub; Tsis txhob muaj cov av noo kom tiv thaiv kom tsis txhob ua kom .
● Kauj: Khub nrog Omega -3 s los txhim kho lipid oxidation lossis berberine rau cov roj bellolism los yog bercose rau cov metabolism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism synergism
Cov ntaub ntawv kho mob
|
Kev Lag Luam Npe |
5- Amino {{}} Metylquinolinium, Schembl6403148, Zmjbceihnowcmc-UhfffaOysa-O, Stl19667 |
|
Cas |
42464-96-0 |
|
Tus hniav loj |
159.21 |
|
Cov lus ntawm ib txoj kab ke |
C10H11N2 |
|
Kev coj dawb huv |
Saum toj no 98% |
|
Kev tsim nyog |
5mg / vial, 10vials / box |
Kev xav tau, thov hu rau peb
Email: Jasonraws106@gmail.com
Whatsapp: +86-15572565525
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Tag
5- Am1 {}}}}}}}}}}}} {2} Kev Tshuaj Xyuas Kev Ua Kom Muaj Kev Tiv Thaiv Kev Ua Si, Kev Ua Yeeb Yam Kev Ua Kom Muaj Kev Tiv Thaiv, Kev Ua Yeeb Yam Kev Ua Kom Muaj Kev Tiv Thaiv Kev Mob
Cim npe nrov: 5- amino {}}}}} {} {{{42464-96-0 Cov chaw tsim khoom, cov chaw tsim khoom, Hoobkas
