5-amino-1mq 5mg 5mg rau Case: 42464-96-0

Dab tsi yog 5-amino-1mq?

5-amino-1-Murtylquinolinium Iodide, feem ntau yog 5-amino-1mq, yog ib qho me me, synthetically muab tau los ntawm quinolinium ntsev. Nws cov qauv txheej txheem nta lub nplhaib quinoline nrog cov methyl pab pawg ntawm lub sijhawm 1-txoj hauj lwm thiab pab pawg amino, nqa tus nqi zoo (cation). Qhov tseeb, nws yogtsisIb qho tshuaj hormone, steroid, lossis xaiv Androgen receptor modulator (sarm). Nws tshwm sim purely raws li kev tshawb fawb tshuaj, feem ntau tau tshawbHauv vitro(xovtooj ntawm tes) thiabHauv vivo(cov qauv tsiaj, feem ntau yog nas). Nws tsis muaj cai tswj tau pom zoo rau tib neeg kev noj tshuaj lossis ntxiv los ntawm lub koom haum loj (FDA, thiab lwm yam.

Qhov kev txhais tau ntawm 5 {{{{2} amino-1mq yog nws lub zog thiab cov xaiv xaiv ntawm nicotinamide n-methyltransferase (NNMT).

NNMT lub luag haujlwm:NNMT yog ib qho enzyme feem pom nyob hauv daim siab thiab adipose (rog) cov ntaub so ntswg. Nws lub luag haujlwm tseem ceeb yog rau methylate nicylate nicylate (ib daim ntawv ntawm cov vitamin B3, kuj yog NAD + precursor) siv s {adenosyl methionine (tib yam) li methyl pub. Qhov tshuaj tiv thaiv no ua rau 1 {{- methylnicototinamide (1-MNA) thiab S-Adenosylocysteine ​​(SAH).

● Cov kev sib tw metabolic:Cov NNMT NNMT yog txuam nrog metabolic dysreregulation, tshwj xeeb yog kev rog thiab cov tshuaj insulin tsis kam. Los ntawm methylating nicotinamide, nnmt zoo:

○ Deplletes cellular NAD +:Nicotinamide yog ib qho tshwj xeeb ua ntej rau nad + biosynthesis ntawm salvage txoj kev. Divering nws mus rau hauv 1-MNA txo cov txheej txheem ntawm cov khoom muaj rau nad + ntau lawm.

O○ Tau muab cov methyl pub:Tib yam, Universal methyl pub, yog noj. Qhov no tuaj yeem cuam tshuam lwm yam tseem ceeb me me methylation tshua thoob plaws lub cev.

○ Ua tus SAH:Sah yog muaj zog inhibitor ntawm cov neeg feem ntau methyltransferases, muaj peev xwm tsim cov methylation dav.

● 5-Amino-1mq kev cuam tshuam:Los ntawm inhibiting nnmt, 5-amino-1mq aim rau:

○ Muaj NAD + Cov Khoom Siv Muaj:Tsawg nicotinamide yog methylated thiab nkim, pub ntau yuav tsum tau rov ua dua tshiab rau hauv nad + ntawm cov ca salvage txoj kev (feem ntawm enzyme nampt). Kev nce siab Nad + theem yog qhov tseem ceeb rau Mitochondrial muaj nuj nqi, kev tsim hluav taws xob (ATP), DNA kho DNA), thiab Sirtuin Actation.

Txuag cov tshuaj methyl:Tsawg dua qub yog noj los ntawm NNMT, muaj peev xwm tso nws rau lwm cov txheej txheem methylation (piv txwv li, neurotransmitter synthesis, DNA methylation).

Txo cov khoom sah tsim:Txo NNMT kev ua si txhais tau tias tsawg sau ntau lawm, muaj peev xwm alleviating inhibition rau lwm methyltransferases.

● Cov txiaj ntsig:Cov hypothesized Cascade rau kev tawm tsam lub cev yog:
    NNMT Inhibition --> Increased NAD+ --> Enhanced Sirtuin Activity (esp. SIRT1) --> Increased Mitochondrial Biogenesis & Function --> Boosted Fatty Acid Oxidation -->Nce kev siv nyiaj txiag thiab muaj roj poob.
Ib qho ntxiv, txhim kho metabolic efficiency thiab txo qhov kev paub ntawm ib puag ncig nnmt) yuav ua rau ib puag ncig Anabolic ntau ntxiv lossis kev loj hlob.

Raws li ntawm nws cov tshuab thiab preclinical pom, 5-amino-1mq yog theorized los siv nyob rau hauv lub cev ua rau:

● Cov roj poob sai:Nov yog qhov nyiaj tau thov thawj. Los ntawm kev txhim kho mitochondrial rog- kub} Kev muaj peev xwm hlawv cov txiaj ntsig ntawm kev txhawb nqa Nad + / Sirtal Kev Siv Nyiaj Txiag ntawm lub zog Nad + / SERTYID BATHING) thiab FATTY ACID oxidation, tshwj xeeb thaum lub sijhawm txwv tsis pub muaj calorie.

● Cov leeg tshuaj tiv thaiv thaum txiav:Tswj cov nqaij ntshiv rog rog thaum nyob hauv qhov muaj txiaj ntsig zoo yog qhov tseem ceeb tshaj plaws rau lub cev. Nce NAD + / SIRT1 kev ua si yuav pab tau bundpress cov leeg protein sib tawg txoj kev thiab txhim kho cov nqaij metabolic, muaj peev xwm tawm cov leeg nqaij thaum txhoj puab heev.

● Txhim kho cov metabolic Health & insulin rhiab rhiab:Los ntawm kev tawm tsam cov metabolic kawg cuam tshuam nrog cov nnmt siab (ua kom muaj kev lom zem ntxiv - muaj peev xwm coj tau zoo dua lub zog ntawm cov leeg thiab deb ntawm cov rog cia.

● Txhim kho lub zog zog qib & endurance:Renated nad + thiab txhim kho mitochondrial muaj nuj nqi tuaj yeem txhais tau kom zoo dua cellular zog ntau lawm (ATP), txo kev qaug zog thiab kev ua haujlwm zoo dua qub thiab rov ua haujlwm.

● Los ntawm {- pa taws teebmeem:Mob ntsws yuav tsum rov qab txoj kev rov qab thiab cov leeg. Txo cov haujlwm nnmt thiab nce nad + / sirt1 tej zaum yuav dampen invarmatory txoj kev.

● Kev txo qhov tseem ceeb tshaj hauv adiposity:Cov kev kawm sib tw muaj cov teebmeem rog rog, txawm tias tsis muaj kev hloov pauv hauv cov zaub mov noj lossis kev tawm dag zog.

● Txhim kho kev ua kom zoo siab thiab cov insulin rhiab:Pom hauv cov nas ua qauv ntawm kev noj haus -}} inducion rog thiab mob ntshav qab zib.

● Muaj kev siv nyiaj ntau ntxiv:Txuas kom txhim kho thermogenesis thiab mitochondrial uncuplings.

Txo cov hepatic steatosis (rog li lub siab):Pom nyob rau hauv tsiaj qauv.

● Cov leeg nqaij - sparing teebmeem (tsis ncaj pov thawj):Thaum cov leeg leeg ncaj qha hypertrophy tsis yog cov nyhuv tshaj tawm, kev khaws cia ntawm cov nqaij ntshiv hauv kev kawm thiab lub luag haujlwm ntawm NaP + hauv cov leeg metabolism qhia tias muaj peev xwm.

Pries Muaj peev xwm los tiv thaiv -}} kev kub ntxhov:Los ntawm NAD + nce thiab sirtin kev ua kom muaj zog (txoj kev ua haujlwm ntev), txawm hais tias qhov tseeb ntawm lub cev yog qhov tseeb yog qib ob.

Qhov tseem ceeb heev Chine: txhua tus tib neeg kev tshuaj thiab cov lus qhia cycling thiab muab tau los ntawm cov ntaub ntawv sib ntxiv. Tsis muaj kev tsim kom muaj kev nyab xeeb lossis muaj kev cai rau tib neeg. Kev siv yog nkaus sim thiab ntawm kev pheej hmoo ntawm tus kheej.

● Cov tshuaj noj (raws li cov qodent expapolation & ausecdote):

Fodent cov kev tshawb fawb feem ntau siv cov tshuaj hauv thaj tsam ntawm 5-50 mg rau ib kg ntawm lub cev hnyavib hnubCov. Ncaj qha rau tib neeg siv cov cheeb tsam nruab nrab ntawm lub cev (cov kev hloov pauv tau yooj yim dua)0.5 mg rau 5 mg rau ib kg ntawm lub cev hnyav ib hnub.

○ Cov ntaub ntawv tshaj tawm los ntawm kev ua sev thaum ntxov hauv zej zog kev ua kom muaj zog feem ntau poob rau hauv100mg rau 300mg tag nrho ib hnub, nquag muab faib ua ob koob (piv txwv li, 100mg kuv, 100mg PM). Qhov no ua kom zoo li ntxhib nrog qis qis kawg ntawm cov hed rau ~ 70-90kg ib tug neeg.Pib ntawm qhov qis qis (piv txwv li, 100mg / hnub) yog qhia.

● Rov mus ncig ntev:

○ Kev tshawb fawb preclinical feem ntau khiav rau ob peb lub lis piam (piv txwv li, 4-12 lub lis piam). Anecdotal Cycles daim iav no, feem ntau yog xws li4 txog 8 lub lis piamCov. Kev voj voog ntev dua tsis muaj cov ntaub ntawv kev nyab xeeb. Vim yog cov tsis paub ntev- kev cuam tshuam, luv luv mus los (4-6 lub lis piam) nrog kev so yog qhov kev so.

Ib nrab - lub neej:

    ○Qhov no yog ib qho tseem ceeb tsis paub.Tsis muaj cov ntaub ntawv luam tawm cov ntaub ntawv (nqus, faib tawm, cov metabolism, {tus neeg nyob hauv tib neeg, thiab cov ntaub ntawv txwv txawm tias hauv cov tsiaj. Nws cov qauv molecular qhia tias nws yuav muaj cov dej solubility tsis pub dhau los vim yog cov cim liprophilic los ntawm lub nplhaib quinoline.Anecdotal cov lus qhia thiab nws cov tshuab qhia cov teebmeem yuav raug txhawb nqa, ua rau cov neeg siv tshuaj ib zaug lossis ob zaug ib hnub.Txog rau thaum cov kev kawm tsim nyog ua tiav, kwv yees ib nrab {{0} Lub neej yuav tsum muaj tsawg kawg ib zaug {1} txhua hnub noj mov yog tsim nyog. Ob zaug -} Kev Dosing (piv txwv li, txhua 12 teev) yog kev coj ua raws li qhov muaj siab rau qib.

● Post -} kev voj voog kev kho (PCT):

    ○PCT feem ntau tsis tau txiav txim siab tsim nyog rau 5-amino-1mq.Tsis zoo li Anabolic Steroids lossis sarms, nws tsis ua raws cov hypothalamic {}} gonadal (hpg) axis. Nws tsis yog kev tsim txom cov testosterone ntau lawm, ua yeeb yam rau hauv estrogen, lossis nthuav tawm cov kev ua haujlwm tseem ceeb thiab ua haujlwm zoo raws li nws paub kev paub txog kev paub txog kev paub. Yog li ntawd, ib puag ncig cov tub ntxhais (piv txwv li, tamoxifen, clomid) lossis hcg {{6} BCT raws cov cai tsis tsim nyog thiab tsis tseem ceeb.

○ Qhov kev txiav txim siab tseem ceeb yuav raug saib xyuas cov kev ntsuas metabolic thiab tag nrho} Kev tsom rau kev tswj hwm kev noj qab haus huv, kev cob qhia regices (piv txwv li nmn) post-}}}}}}}}}}}}}}}}}

● Tsis muaj tib neeg cov ntaub ntawv:Qhov no tsis tuaj yeem ua kom dhau.XumCov tuam tsev kho mob ruaj khov nyob tau muaj. Txhua cov txiaj ntsig kev lees paub rau kev ua kom lub cev yog cov khoom ntawm cov nas thiab nas. Tib neeg lub cev muaj zog.

● Cov ntaub ntawv tsis paub txog kev nyab xeeb:Cov kev mob tshwm sim tshwm sim hauv tib neeg muaj kev tsis paub ntau. Muaj kev txhawj xeeb ua tau raws li kev siv tshuab lossis anecdote xws li:

    ○Methylation Francalance:Thaum conserving tib yam yog cov txiaj ntsig, hloov pauv nurotransmation pathwaysy, muaj peev xwm cuam tshuam cov xwm txheej ntawm methylation (pethylation (pethylation (istamine metabolism, thiab ntau dua. Cov tsos mob yuav yog dav - ranging thiab hloov maj mam.

    ○Kev ntxhov siab hauv lub plab zom mov:Xeev siab, mob plab chim siab, lossis zawv plab yog tau tshaj tawm anecdotally, tshwj xeeb yog cov koob tshuaj ntau dua lossis pib.

    ○Mob taub hau / Qeeb zog:Qee tus neeg siv daim ntawv qhia thawj zaug mob taub hau lossis nkees.

    ○Ntev - lub sij hawm agon ocicity:Tsis muaj cov ntaub ntawv muaj nyob rau ntawm kev mob siab rau daim siab, raum, lub plawv, lossis hlwb nrog kev siv mob ntev.

    ○Muaj peev xwm cuam tshuam ntawm ib - cov roj metabolism:Lub Interlay ntawm NNMT inhibition, tib yam, homocysteine, kev ua tiav, thiab b12 mus thiab b12 cycles yog complex thiab tsis nkag siab hauv cov ntsiab lus no.

● Purity thiab Sourcing:Raws li kev tshawb fawb tshuaj, nws yog muag los ntawm cov neeg xa khoom tsis muaj kev txwv. Purity, paug (cov kuab tshuaj, cov hlau hnyav), thiab cov koob tshuaj hnyav), thiab kev txhawj xeeb yog yog qhov kev txhawj xeeb tseem ceeb. Tsis muaj kev tswj hwm zoo.

Them Nqi:Nws yog feem ntau kim tus neeg txheeb ze rau nws cov txiaj ntsig tau txais kev pab hauv tib neeg.

● Cov xwm txheej raug cai:Nws muaj nyob rau hauv thaj chaw grey, tsis pom zoo rau tib neeg tau txais tab sis nquag muag raws li kev tshawb fawb tias yog kev siv tib neeg. " Cov cai sib txawv txawv ntawm lub teb chaws.

Kev Sib Tham:Cov kev cuam tshuam muaj peev xwm nrog cov tshuaj los yog lwm cov tshuaj pab tsis paub kiag li.

Kev Lag Luam Npe	5-amino-1-Methylquinolinium, SchembliTinium, Schembl6403148, DiagBl4116828, ZMJBCEIhnowcmc - uhfffaoysa-} o, stl196667
Cas	42464-96-0
Tus hniav loj	159.21
Cov lus ntawm ib txoj kab ke	C10H11N2
Kev coj dawb huv	Saum toj no 98%
Kev tsim nyog	5mg / vial, 10vials / box

 

 

Kev xav tau, thov hu rau peb

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5-amino-1mq nthuav qhia muaj kev txaus siab thiab nthuav dav rog rau cov muaj kev ua rog poob thiab kev ua tau zoo ntawm NNMT thiab nce qib NAD + qib. Cov ntaub ntawv ua haujlwm ua ntej hauv cov nas ua tiav, qhia qhov kev txo qis loj hauv cov rog loj thiab kev txhim kho hauv cov qauv metabolic. Rau kev ua kom lub cev ua haujlwm ntawm lub cev, cov ntawv thov theoretical - nrawm txiav, kho cov leeg txuag, txhim kho cov tshuaj ntsuab, thiab ua kom zoo nkauj heev.

Txawm li cas los xij, kev hla ntawm nas rau tib neeg loj heev.Cov tiav kev ua tiav ntawm tib neeg kev nyab xeeb thiab cov ntaub ntawv ua tau zoo yog qhov kev txhawj xeeb ntawm qhov kev txhawj xeeb.Dosing, kev caij tsheb kauj vab, thiab nkag siab cov kev mob tshwm sim yog ua raws li kev rho tawm thiab anecdote, tsis yog science. Lub peev xwm rau kev cuam tshuam txog kev tseem ceeb methylation cov pathwent, tsis paub txog kev txaus ntshai. Qhov kev noj thiab kev ua kom muaj teeb meem kev nyab xeeb ntxiv lwm txheej ntawm kev phom sij.

Yog li ntawd, thaum muaj 5-amino-1mQ sawv cev rau qhov kev ua si hauv metique hauv cov duab metique rau kev ceev faj, thiab tag nrho kev nkag siab tias nws siv yog kev sim siab. Nws yogtsisIb qho kev hloov pauv rau cov khoom siv pov thawj: kev noj haus ceevas, kev pw tsaug zog tsis txaus, thiab kev tswj hwm txaus siab. Leej twg los xav tias nws yuav tsum nyhav lub peev xwm, tseem muaj kev txaus siab, tsis txaus ntseeg nyob rau hauv ob qho kev txaus ntshai thiab cov kev taw qhia yuav muaj kev txwv los ntawm cov ntaub ntawv). Tam sim no, nws nyob ruaj khov nyob rau hauv lub realm ntawm kev sim tshawb fawb, tsis tsim kev coj ua lub cev.

Cim npe nrov: 5-amino-1mq 5mg 5mg rau Case: 42464-96-0, Suav 5mQ 5MQ 5MQ 5MG 5M4-96 -0 tuam ntxhab, cov chaw muag khoom, Hoobkas