Tsis yog, RAD140 tsis ncaj qha nce Dihydrotestosterone (DHT) qib.Qhov tseeb, qee qhov kev tshawb fawb qhia tias nws yuav me ntsisqisDHT.
Txawm li cas los xij, kev sib raug zoo yog nuanced, thiab kev txhawj xeeb txog DHT feem ntau tshwm sim los ntawm nws cov kev mob tshwm sim (xws li plaub hau poob). Nov yog cov ncauj lus kom ntxaws:
1. Direct Mechanism: RAD140 Tsis yog Precursor rau DHT
● DHTyog ib tug muaj zog ntuj androgen muab tau los ntawm kev hloov dua siab tshiab ntawmtestosteronelos ntawm enzyme * 5-alpha reductase *.
● RAD140yog ib qho hluavtaws, tsis yog -steroidal Selective Androgen Receptor Modulator (SARM). Nws yogtsis yogtestosterone thiab tsis hloov mus rau DHT. Nws khi ncaj qha rau androgen receptors nyob rau hauv cov nqaij thiab pob txha cov ntaub so ntswg nrog siab affinity.
2. Qhov Kev Tshawb Fawb Qhia
●Cov kev tshawb fawb ua ntej (hauv vitro thiab tsiaj qauv) qhia tias RAD140 muaj kev sib raug zoo tsawg heev rau kev metabolized los ntawm 5-alpha reductase. Nws yog tsim los ua anabolic hauv cov leeg thiab pob txha thaum muaj cov teebmeem androgenic tsawg heev hauv cov ntaub so ntswg xws li tawv taub hau thiab prostate.
●Qee qhov kev tshawb fawb tsiaj tau pom tias kev tswj hwm RAD140 tuaj yeem ua rau ib qhotxo qis hauv tag nrho cov testosterone(vim HPTA suppression). Txij li testosterone yog qhov ua ntej rau DHT, qhov no tuaj yeem ua rau tsis ncajqis dua DHTdhau sijhawm.
3. Vim li cas qhov tsis meej pem txog plaub hau poob (Androgenic Side Effects)?
Ntau tus neeg siv tshaj tawm cov plaub hau los yog ua kom cov txiv neej ua baldness thaum noj RAD140. Qhov no tsim qhov kev xav tias DHT yuav tsum siab. Cov lus piav qhia txawv:
● Direct Receptor Activation:RAD140 nws tus kheej, thaum xaiv,tseem tuaj yeem khi rau androgen receptors hauv tawv taub hau follicles. Yog tias koj muaj cov kab mob genetic predisposed rau androgenetic alopecia, ua kom cov receptors no -txawm yog los ntawm DHT los yog SARM muaj zog- tuaj yeem ua rau lossis ua kom cov plaub hau poob.
● Androgen Receptor Upregulation:Qee qhov kev xav qhia tias SARMs tuaj yeem tswj hwm androgen receptors hauv qee cov ntaub so ntswg, ua rau lawv nkag siab ntau dua rau cov androgens tam sim no.
● Hloov hauv Hormone Ratios:Kev cuam tshuam hnyav ntawm ntuj testosterone (thiab tom qab DHT) thaum lub zog exogenous zoo li RAD140 nquag tuaj yeem tsim qhov tsis zoo ntawm cov tshuaj hormones uas yuav ua rau cov plaub hau follicle.
4. Tus Prostate Aspect
Kev txhawj xeeb txog DHT kuj tseem txuas rau kev noj qab haus huv ntawm prostate (Benign Prostatic Hyperplasia - BPH). Txij li thaum RAD140 qhia tau hais tias tsis tshua muaj kev ua haujlwm hauv prostate hauv cov qauv ua ntej thiab tsis hloov mus rau DHT, nws yog qhov kev xav kom muaj kev nyab xeeb zoo dua rau prostate dua li testosterone. Txawm li cas los xij,qhov no tsis muaj pov thawj hauv tib neeg.
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