Nolvadex, lub npe hu ua Tamoxifen, yog ib qho kev xaiv tshuaj estrogen receptor modulator (SERM) dav siv hauv kev kho mob thiab tiv thaiv mob qog noj ntshav. Tsim nyob rau xyoo 1960 thiab tau pom zoo rau kev siv kho mob hauv xyoo 1970, nws tau dhau los ua lub hauv paus hauv kev kho mob qog noj ntshav.
Tamoxifen ua haujlwm los ntawm kev khi rau cov tshuaj estrogen receptors hauv cov ntaub so ntswg ntawm lub mis, thaiv cov tshuaj estrogen lub peev xwm los txhawb kev loj hlob ntawm cov qog nqaij hlav cancer mis. Qhov no ua rau nws muaj txiaj ntsig tshwj xeeb hauv kev kho cov tshuaj estrogen receptor-positive (ER-positive) mob qog noj ntshav mis, uas yog qhov tseem ceeb ntawm cov mob qog noj ntshav mis. Los ntawm inhibiting estrogen qhov kev txiav txim, Tamoxifen pab txo qhov kev pheej hmoo ntawm kev mob qog noj ntshav thiab kev loj hlob.
Ntxiv rau nws txoj kev siv tshuaj kho mob qog noj ntshav uas twb muaj lawm, Tamoxifen kuj tau sau tseg tias yog kev tiv thaiv kev tiv thaiv rau cov tib neeg uas muaj kev pheej hmoo loj ntawm tus kab mob. Qhov no suav nrog cov poj niam uas muaj tsev neeg keeb kwm mob qog noj ntshav mis lossis cov uas muaj qee yam kev hloov pauv caj ces, xws li BRCA1 lossis BRCA2. Cov kev tshawb fawb soj ntsuam tau pom tias Tamoxifen tuaj yeem txo qhov kev pheej hmoo ntawm kev mob qog noj ntshav mis hauv cov neeg muaj kev pheej hmoo siab kwv yees li 50%.
Tamoxifen feem ntau yog siv los ntawm qhov ncauj hauv daim ntawv ntsiav tshuaj, nrog rau tus qauv ntau npaum li ntawm 20 mus rau 40 mg ib hnub, nyob ntawm seb tus mob tshwj xeeb thiab cov lus teb ntawm tus neeg mob. Kev kho mob ntev tuaj yeem sib txawv, feem ntau kav ntev li tsib mus rau kaum xyoo kom ua kom nws cov txiaj ntsig zoo tshaj plaws los tiv thaiv thiab kho.
Thaum Tamoxifen feem ntau ua tau zoo, nws tuaj yeem ua rau muaj kev phiv. Cov kev mob tshwm sim muaj xws li kub kub, qhov chaw mos qhuav, thiab kev coj khaub ncaws tsis xwm yeem. Cov kev mob tshwm sim loj dua tab sis tsis tshua muaj tshwm sim suav nrog kev pheej hmoo ntawm kev mob qog noj ntshav endometrial, ntshav txhaws, thiab mob stroke. Yog li, cov neeg mob noj Tamoxifen yuav tsum tau saib xyuas thiab ua raws li lawv tus kws kho mob.
Zuag qhia tag nrho, Tamoxifen tseem yog ib qho tshuaj tseem ceeb hauv kev tawm tsam mob qog noj ntshav mis, muab cov txiaj ntsig tseem ceeb rau kev kho mob thiab kev tiv thaiv. Nws lub luag haujlwm hauv kev tswj ER-zoo mob qog noj ntshav mis thiab txo qhov kev pheej hmoo ntawm cov neeg muaj kev pheej hmoo siab underscores nws qhov tseem ceeb hauv oncology.
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