Kev nqus sai sai tom qab kev tswj hwm qhov ncauj, nrog lub sijhawm nruab nrab ntawm 2 teev tom qab kev tswj hwm mus txog qhov nruab nrab qhov siab tshaj plaws ntawm cov ntshav plasma concentration (cmax). Qhov tseeb bioavailability ntawm cov khoom no tom qab kev tswj qhov ncauj tseem tsis tau meej meej. Qhov nqus tau thiab qib ntawm Tadalafil tsis cuam tshuam los ntawm cov khoom noj, yog li cov khoom no tuaj yeem noj nrog lossis tsis muaj zaub mov. Lub sij hawm ntawm kev tswj hwm (sab sawv ntxov lossis yav tsaus ntuj) tsis muaj qhov cuam tshuam tseem ceeb ntawm kev nqus thiab degree. Qhov nruab nrab faib ntim yog kwv yees li 63 litres, qhia tias Tadalafil tau faib rau hauv cov ntaub so ntswg. Ntawm kev kho mob concentration, 94 feem pua ntawm Tadalafil hauv plasma yog khi rau cov protein. Protein khi tsis cuam tshuam los ntawm lub raum tsis ua haujlwm. Hauv cov neeg noj qab haus huv, qhov nruab nrab qhov kev tshem tawm ntawm qhov ncauj Tadalafil yog 2.5 L / hr, thiab qhov nruab nrab ntawm lub neej yog 17.5 teev. Tadalafil feem ntau yog tawm hauv daim ntawv ntawm cov metabolites tsis ua haujlwm, feem ntau los ntawm cov quav (kwv yees 61 feem pua ntawm cov koob tshuaj), thiab ib feem me me tau tawm hauv cov zis (kwv yees li 36 feem pua ntawm cov koob tshuaj).
