SR9009, tseem hu ua Stenabolic, yog ib qho kev tshawb fawb hluavtaws uas nws cov txheej txheem tseem ceeb ntawm kev ua haujlwm yog ua tus agonist ntawm REV-ERB nuclear receptors. Txawm li cas los xij, nws cov teebmeem lom neeg yog qhov nyuaj thiab koom nrog REV-ERB- txoj hauv kev nyob thiab txoj kev ywj pheej.
🧬 Primary Mechanism: Agonism of REV-ERB Nuclear Receptors
Lub luag haujlwm tseem ceeb ntawm SR9009 yog khi rau thiab ua kom REV-ERB thiab REV-ERB nuclear receptors. Cov receptors no yog cov ntsiab lus tseem ceeb ntawm lub cev lub moos circadian thiab ua raws li kev hloov pauv hloov pauv. Cov txheej txheem ua kom ua haujlwm ua haujlwm raws li hauv qab no:
1.Kev khi thiab ua kom muaj zog: SR9009 khi ncaj qha rau ligand-binding domain ntawm REV-ERB receptors. Qhov no stabilizes lub receptor nyob rau hauv ib tug conformation uas txhim khu nws natural repressive muaj nuj nqi.
2.Recruitment of Co-repressor Complex: Thaum ua kom tiav, REV-ERB receptor nquag nrhiav cov co-repressor complex, uas feem ntau muaj Nuclear Receptor Co-repressor 1 (NCoR) thiab Histone Deacetylase 3 (HDAC3).
3.Txoj kev ntxeev siab: Qhov nyuaj no khi rau cov DNA ib ntus (REV-ERB Response Elements lossis ROREs) ntawm cov hom phiaj. Lub HDAC3 enzyme ces hloov cov qauv chromatin, ua rau nws ntau compact thiab nkag tsis tau rau lub cellular machinery uas sau cov noob. Qhov no ua tau zoo "tawm" lossis ua rau lub hom phiaj cov noob.
Lub hom phiaj tseem ceeb ntawm kev tsim txom no yog qhovBmal 1gene, tus thawj tswj hwm ntawm lub moos circadian. Los ntawm suppressingBmal 1, SR9009 ncaj qha hloov cov txheej txheem moos tseem ceeb, ua rau muaj kev hloov pauv hauv kev sib dhos ntawm ntau lwm cov noob koom nrog hauv cov metabolism thiab tus cwj pwm.
⚙️ REV-ERB-Txoj kev ywj pheej
Qhov tseem ceeb, kev tshawb fawb tau pom tias SR9009 tuaj yeem ua rau muaj txiaj ntsig lom neeg txawm tias REV-ERB receptors tsis tuaj. Qhov no qhia tau tias qee qhov ntawm nws qhov kev ua yog ywj pheej ntawm nws lub hom phiaj tseem ceeb:
● Ua kom muaj NRF2 Txoj Kev: SR9009 tuaj yeem qhib txoj hauv kev NRF2, uas yog lub luag haujlwm tseem ceeb ntawm cov xov tooj ntawm tes tiv thaiv kev ntxhov siab oxidative. Qhov no ua rau txo qis hauv cov pa oxygen reactive (ROS) los ntawm kev tswj cov kev qhia ntawm cov enzymes antioxidant.
●Txoj cai ntawm lwm txoj kev teeb pom kev zoo: Cov kev tshawb fawb tau pom tias SR9009 tuaj yeem cuam tshuam rau lwm txoj hauv kev, xws li inhibiting NOX4/p38 thiab ERK signaling pathways, modulating NF-κB txoj hauv kev los tiv thaiv- cov teebmeem inflammatory, thiab tswj LXR / FOXM1 txoj kev ywj pheej ntawm REV-ERBs
📈 Qhov tshwm sim Physiological Effects
Los ntawm cov txheej txheem nyuaj no, SR9009 tau raug pom los tsim ntau yam teebmeem hauv kev tshawb fawb preclinical, suav nrog:
● Hloov Circadian Rhythm: Cov kev hloov pauv hauv kev ua haujlwm hauv locomotor thiab cov qauv qhia ntawm cov core moos genes.
● Kev siv hluav taws xob ntau ntxiv: Kev hloov pauv hauv kev qhia txog cov tshuaj metabolic hauv lub siab, cov leeg pob txha, thiab cov ntaub so ntswg adipose.
● Txo cov rog rog thiab txhim kho Metabolic Markers: Hauv kev noj haus-cov nas rog rog, SR9009 txo cov rog rog thiab txhim kho dyslipidemia thiab hyperglycemia.
●Anti-Cov teebmeem inflammatory: Txo cov lus teb inflammatory hauv ntau hom cell.
Txhim kho Mitochondrial Biogenesis: Kev nce ntxiv ntawm cov mitochondria hauv cov leeg pob txha pob txha, muaj peev xwm los ntawm kev tawm tsam autophagy- ntsig txog cov noob.
● Ua kom muaj peev xwm ua tau zoo: Hauv cov qauv tsiaj, cov nas uas kho tau pom tias muaj kev txhim kho hauv lub sijhawm khiav thiab nyob deb.
Nws yog ib qho tseem ceeb kom nco ntsoov tias SR9009 yog cov tshuaj tshawb fawb thiab tsis pom zoo rau tib neeg siv. Nws cov teebmeem tseem tab tom tshawb nrhiav, thiab nws txoj kev nyab xeeb thiab kev ua tau zoo ntawm tib neeg tsis tau tsim.
https://www.hormonerawsource.com/sarm-powder/sarms-finished/high-zoo-stromusc-sr9009-10mg-for.html
